TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 568.62 | Formula: C32H32N4O6
H donors: 5 H acceptors: 3 LogP: 4.19 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H]1N[C@H](c2cc(OC)c(c(c2)OC)O)c2c(C1)c1ccccc1[nH]2
InChi: 1S/C32H32N4O6/c1-40-26-13-17(14-27(41-2)30(26)37)28-29-21(20-9-5-7-11-23(20)34-29)15-24(35-28)31(38)36-25(32(39)42-3)12-18-16-33-22-10-6-4-8-19(18)22/h4-11,13-14,16,24-25,28,33-35,37H,12,15H2,1-3H3,(H,36,38)/t24-,25+,28+/m0/s1
InChiKey: BCOUSJIONPLFAF-BXTSTYNKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Onchocerca volvulus		0.0037	0.0172	0.1365
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0295	0.0295
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0185	0.004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0237	0.0453
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0029	0.0079	0.0282
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0037	0.0179	0.0343
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Trypanosoma cruzi	cyclin, putative	0.0042	0.0237	0.0387
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.012	0.12	0.1502
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Onchocerca volvulus		0.0042	0.0237	0.1874
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.0496	0.062
Brugia malayi	cathepsin B-like cysteine proteinase	0.0448	0.5227	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0151	0.1574	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0092	0.0849	0.5287
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0037	0.0179	0.3112
Trichomonas vaginalis	cyclins, putative	0.0042	0.0237	0.1305
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Trichomonas vaginalis	cyclins, putative	0.0042	0.0237	0.1305
Brugia malayi	calpain family protein 1	0.006	0.0462	0.0884
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0037	0.0179	0.3112
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0042	0.0237	0.0387
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0497	0.0951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0179	0.0933
Onchocerca volvulus		0.0037	0.0179	0.1421
Giardia lamblia	Cathepsin B precursor	0.0151	0.1574	1
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0082	0.0156
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0136	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0179	0.0225
Loa Loa (eye worm)	proprotein convertase 2	0.0036	0.0159	0.0303
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0179	0.0343
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0295	0.037
Brugia malayi	celfurPC protein	0.0122	0.1218	0.2331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0179	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0092	0.0849	0.5287
Echinococcus multilocularis		0.0122	0.1218	0.1218
Onchocerca volvulus		0.012	0.12	0.9501
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0063	0.0496	0.062
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.0266	0.0266
Echinococcus granulosus	calpain A	0.0063	0.0496	0.062
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0237	0.0453
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0179	0.7151
Leishmania major	hypothetical protein, conserved	0.0063	0.0497	0.2277
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Echinococcus granulosus	furin	0.0151	0.1578	0.1975
Onchocerca volvulus		0.0037	0.0172	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0185	0.0185
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0185	0.0969
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Giardia lamblia	Cathepsin B precursor	0.0151	0.1574	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0026	0.0036	0.0045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Schistosoma mansoni	furin-1 (S08 family)	0.0066	0.0528	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0449	0.0858
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.799	0.799
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0082	0.2275
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.799	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.006	0.0462	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Loa Loa (eye worm)	cysteine protease	0.0037	0.0179	0.0343
Onchocerca volvulus		0.0037	0.0172	0.1365
Trypanosoma cruzi	cruzipain precursor, putative	0.0037	0.0179	0.0276
Onchocerca volvulus		0.0037	0.0179	0.1421
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0172	0.033
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.0156
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	hypothetical protein	0.0029	0.0079	0.0282
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0185	0.0969
Onchocerca volvulus	Cathepsin F homolog	0.0037	0.0179	0.1421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0185	1
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0179	0.7151
Schistosoma mansoni	hypothetical protein	0.0063	0.0497	0.0622
Onchocerca volvulus		0.0038	0.0182	0.1442
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0448	0.5227	0.6542
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Onchocerca volvulus		0.0037	0.0172	0.1365
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0237	0.0453
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0237	0.1305
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0179	0.7151
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Onchocerca volvulus		0.0037	0.0172	0.1365
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0295	0.037
Echinococcus multilocularis	calpain A	0.0063	0.0496	0.0496
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Brugia malayi	neuroendocrine convertase 1 precursor	0.0095	0.0887	0.1698
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.0415	0.052
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0448	0.5227	0.6542
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0082	0.0297
Brugia malayi	hypothetical protein	0.0125	0.1263	0.2416
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1263	1
Onchocerca volvulus		0.0029	0.0082	0.0646
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0151	0.1578	0.1975
Schistosoma mansoni	lipoxygenase	0.0057	0.0415	0.052
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0037	0.0179	0.0225
Echinococcus multilocularis	cathepsin b	0.0448	0.5227	0.5227
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0295	0.0295
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0172	0.033
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Echinococcus multilocularis	neuroendocrine convertase 2	0.0095	0.0887	0.0887
Echinococcus multilocularis	cysteine protease	0.0037	0.0179	0.0179
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0037	0.0179	0.0225
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0063	0.0496	0.0496
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Schistosoma mansoni	hypothetical protein	0.0029	0.0079	0.0099
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0185	0.0287
Giardia lamblia	G2/mitotic-specific cyclin B	0.0042	0.0237	0.1053
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0179	0.0276
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0029	0.0079	0.0282
Echinococcus multilocularis	cysteine protease	0.0037	0.0179	0.0179
Entamoeba histolytica	cyclin, putative	0.0042	0.0237	1
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Plasmodium falciparum	cysteine repeat modular protein 1	0.0063	0.0497	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Onchocerca volvulus		0.0037	0.0179	0.1421
Brugia malayi	proprotein convertase 2	0.0095	0.0887	0.1698
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Toxoplasma gondii	kringle domain-containing protein	0.0063	0.0497	0.0863
Brugia malayi	calpain family protein 1	0.006	0.0462	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Onchocerca volvulus		0.0037	0.0172	0.1365
Toxoplasma gondii	PAN domain-containing protein	0.0342	0.3932	1
Plasmodium vivax	vivapain-2	0.0037	0.0179	0.3112
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.0156
Loa Loa (eye worm)	TK/ROR protein kinase	0.0063	0.0497	0.0951
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Loa Loa (eye worm)	inositol-1	0.0038	0.0185	0.0354
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.006	0.0462	0.0578
Trypanosoma brucei	mitotic cyclin 6	0.0042	0.0237	0.1305
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0448	0.5227	0.6542
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0092	0.0849	0.1063
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0266	0.0509
Echinococcus granulosus	cathepsin l1	0.0037	0.0179	0.0225
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0172	0.033
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0151	0.1574	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0179	0.0179
Echinococcus granulosus	cathepsin b	0.0448	0.5227	0.6542
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0063	0.0497	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0185	0.0969
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0151	0.1574	0.197
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0185	0.0232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Echinococcus granulosus	tissue type plasminogen activator	0.0063	0.0497	0.0622
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0029	0.0082	0.0156
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0237	0.1305
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0179	0.0276
Onchocerca volvulus		0.0037	0.0172	0.1365
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0179	0.0179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Echinococcus multilocularis	cathepsin b	0.0448	0.5227	0.5227
Onchocerca volvulus		0.0037	0.0179	0.1421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.0496	0.062
Brugia malayi	cathepsin L-like precursor	0.0029	0.0082	0.0156
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0029	0.0082	0.0088
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0172	0.033
Brugia malayi	Inositol-1	0.0038	0.0185	0.0354
Echinococcus granulosus	cathepsin b	0.0448	0.5227	0.6542
Toxoplasma gondii	subtilisin SUB12	0.0043	0.0252	0.0211
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0036	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0179	0.0179
Onchocerca volvulus		0.0037	0.0172	0.1365
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0179	0.1421
Toxoplasma gondii	PAN domain-containing protein	0.0342	0.3932	1
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0092	0.0849	0.0849
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0036	0.0045
Trichomonas vaginalis	cyclin A, putative	0.0042	0.0237	0.1305
Echinococcus multilocularis	tissue type plasminogen activator	0.0063	0.0497	0.0497
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0179	0.0179
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0029	0.0079	0.0282
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Brugia malayi	Kringle domain containing protein	0.0063	0.0497	0.0951
Giardia lamblia	Cathepsin B precursor	0.0151	0.1574	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0295	0.037
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0179	0.0276
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0082	0.0156
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Brugia malayi	endoprotease bli-4 precursor	0.0151	0.1578	0.3018
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0151	0.1574	1
Schistosoma mansoni	cyclin B	0.0042	0.0237	0.0296
Echinococcus multilocularis	cathepsin L	0.0026	0.0036	0.0036
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Echinococcus granulosus	cathepsin L	0.0026	0.0036	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0266	0.0509
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0185	0.0034
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Echinococcus granulosus	cysteine protease	0.0026	0.0036	0.0045
Trichomonas vaginalis	cyclins, putative	0.0042	0.0237	0.1305
Onchocerca volvulus		0.0037	0.0179	0.1421
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0295	0.0565
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0179	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0497	0.0951
Onchocerca volvulus		0.0037	0.0179	0.1421
Brugia malayi	Trypsin family protein	0.012	0.12	0.2295
Echinococcus granulosus	Furin 1	0.0036	0.0159	0.0199
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0295	0.0565
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0036	0.0069
Onchocerca volvulus		0.0037	0.0172	0.1365
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1263	0.2416
Loa Loa (eye worm)	ctsf protein	0.0037	0.0179	0.0343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0378	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0082	0.0297
Leishmania major	cyclin	0.0042	0.0237	0.041
Plasmodium vivax	vivapain-2	0.0037	0.0179	0.3112
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1578	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Trichomonas vaginalis	cyclins, putative	0.0029	0.0073	0.0242
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0185	0.0232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0237	0.1305
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0179	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0448	0.5227	1
Echinococcus granulosus	cyclin B	0.0042	0.0237	0.0296
Toxoplasma gondii	cathepsin B	0.0151	0.1574	0.3728
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Echinococcus multilocularis	cyclin B	0.0042	0.0237	0.0237
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0172	0.033
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1263	0.2416
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0136	0.5
Loa Loa (eye worm)	cathepsin B	0.0151	0.1574	0.3011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0295	0.037
Loa Loa (eye worm)	hypothetical protein	0.012	0.12	0.2295
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.056	0.6615	0.6615
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0041
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0185	0.0232
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.799	1
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0179	0.0225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0151	0.1574	0.2963
Echinococcus granulosus	neuroendocrine convertase 2	0.0095	0.0887	0.1111
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0237	0.1305
Loa Loa (eye worm)	hypothetical protein	0.012	0.12	0.2295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Loa Loa (eye worm)	endoprotease bli-4	0.0151	0.1578	0.3018
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0036	0.0159	0.0199
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0185	0.743
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0295	0.037
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0448	0.5227	0.6542
Toxoplasma gondii	cathepsin CPL	0.0037	0.0179	0.0019
Onchocerca volvulus		0.0063	0.0497	0.3936
Giardia lamblia	High cysteine membrane protein Group 2	0.0056	0.041	0.2214
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.0179	0.0343
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0185	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0172	0.033
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0037	0.0179	0.3112
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0036	0.0159	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0179	0.0343
Loa Loa (eye worm)	fibroinase	0.0037	0.0179	0.0343
Trichomonas vaginalis	cyclins, putative	0.0042	0.0237	0.1305
Echinococcus granulosus	cathepsin l1	0.0029	0.0082	0.0102
Onchocerca volvulus		0.0037	0.0172	0.1365
Onchocerca volvulus		0.0037	0.0179	0.1421
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0185	0.0969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0179	0.0933
Loa Loa (eye worm)	calpain family protein 1	0.006	0.0462	0.0884
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0237	0.0453
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0448	0.5227	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0185	0.0287
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0036	0.0045
Onchocerca volvulus		0.0037	0.0172	0.1365
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.0156
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0082	0.0102
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Onchocerca volvulus		0.0098	0.092	0.7283
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0182	0.0348
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.012	0.12	0.1502
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0079	0.0282
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0042	0.0237	0.041
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0497	0.0888
Trypanosoma cruzi	cyclin, putative	0.0042	0.0237	0.0387
Brugia malayi	PAN domain containing protein	0.0037	0.0172	0.033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0179	0.0343
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0036	0.0045
Echinococcus multilocularis	Furin 1	0.0036	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0179	0.0933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1263	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Trypanosoma cruzi	cyclin 6, putative	0.0042	0.0237	0.0387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0179	0.0933
Echinococcus granulosus	tm gpcr rhodopsin	0.056	0.6615	0.8279

Activities

Activity type	Activity value	Assay description	Source	Reference
Cell survival (functional)	= 7.2 %	In vitro cell growth inhibition of H520 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 100 uM	ChEMBL.	11392530
Cell survival (functional)	= 35.2 %	In vitro cell growth inhibition of H520 cell line determined using non-radioactive cell proliferation assay at a dose of 50 uM	ChEMBL.	11392530
Cell survival (functional)	= 62.4 %	In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 100 uM	ChEMBL.	11392530
Cell survival (functional)	= 62.4 %	In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 100 uM	ChEMBL.	11392530
Cell survival (functional)	= 84.9 %	In vitro cell growth inhibition of PC3 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 50 uM	ChEMBL.	11392530
Cell survival (functional)	= 84.9 %	In vitro cell growth inhibition of PC3 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 50 uM	ChEMBL.	11392530
Cell survival (functional)	> 100 %	In vitro cell growth inhibition of H520 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM	ChEMBL.	11392530
Cell survival (functional)	> 100 %	In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM	ChEMBL.	11392530
Cell survival (functional)	> 100 %	In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM	ChEMBL.	11392530
DNA relaxation (functional)	0	Inhibition of topo II-mediated DNA relaxation measured by topo II-mediated DNA relaxation assay; +++ indicates drug interaction with topo II	ChEMBL.	11392530

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 27374