Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thyroid hormone receptor beta-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Thyroid hormone receptor beta-1 | 461 aa | 372 aa | 29.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | Thyroid hormone receptor beta-1 | 461 aa | 409 aa | 24.7 % |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | Thyroid hormone receptor beta-1 | 461 aa | 377 aa | 24.1 % |
Brugia malayi | nuclear hormone receptor | Thyroid hormone receptor beta-1 | 461 aa | 405 aa | 26.7 % |
Loa Loa (eye worm) | hypothetical protein | Thyroid hormone receptor beta-1 | 461 aa | 397 aa | 25.4 % |
Onchocerca volvulus | Thyroid hormone receptor beta-1 | 461 aa | 383 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.0602 | 0.4184 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0251 | 0.0829 | 0.1982 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.2571 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.4107 | 0.4082 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0043 | 0.0072 |
Loa Loa (eye worm) | integrin beta-2 | 0.0339 | 0.1669 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0182 | 0.014 |
Echinococcus multilocularis | integrin alpha ps | 0.0352 | 0.1795 | 0.429 |
Echinococcus granulosus | integrin beta 2 | 0.0251 | 0.0829 | 0.1899 |
Schistosoma mansoni | integrin alpha-ps | 0.0183 | 0.0182 | 0.0307 |
Echinococcus granulosus | integrin alpha ps | 0.0352 | 0.1795 | 0.4231 |
Schistosoma mansoni | integrin beta subunit | 0.0199 | 0.0337 | 0.0568 |
Echinococcus granulosus | integrin alpha 3 | 0.0602 | 0.4184 | 1 |
Schistosoma mansoni | integrin alpha | 0.0785 | 0.5936 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0352 | 0.1795 | 0.429 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0594 | 0.4107 | 0.5715 |
Schistosoma mansoni | integrin alpha-ps | 0.0352 | 0.1795 | 0.3024 |
Echinococcus multilocularis | integrin alpha ps | 0.0169 | 0.0043 | 0.0103 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0785 | 0.5936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.4323 | 0.4298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 nM | Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. | ChEMBL. | 7861417 |
IC50 (binding) | = 1.5 nM | Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. | ChEMBL. | 7861417 |
IC50 (binding) | > 5 uM | In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | ChEMBL. | 7861417 |
IC50 (binding) | > 5 uM | In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | ChEMBL. | 7861417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.