Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Schistosoma mansoni | carbonic anhydrase | 0.1483 | 0.3381 | 0.3381 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0249 | 0.0249 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4317 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1629 | 0.372 | 0.372 |
Schistosoma mansoni | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0249 | 0.0249 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1629 | 0.372 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 0.372 | 0.3549 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4317 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0149 | 0.0149 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1629 | 0.372 | 0.372 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.007 | 0.0079 | 0.0211 |
Brugia malayi | hypoxia-induced factor 1 | 0.0149 | 0.0265 | 0.0265 |
Leishmania major | carbonic anhydrase-like protein | 0.4317 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.007 | 0.0079 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4317 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4317 | 1 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0029 | 0.0029 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0249 | 0.0249 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4317 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.2031 | 0.4661 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1629 | 0.372 | 0.3549 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1629 | 0.372 | 0.372 |
Plasmodium falciparum | carbonic anhydrase | 0.1629 | 0.372 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0586 | 0.1285 | 0.3884 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4317 | 1 | 1 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0029 | 0.0029 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1483 | 0.3381 | 1 |
Onchocerca volvulus | 0.0067 | 0.0073 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.1629 | 0.372 | 0.372 |
Echinococcus granulosus | carbonic anhydrase II | 0.4317 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 0.372 | 0.3549 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1629 | 0.372 | 0.372 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0803 | 0.1793 | 0.1793 |
Toxoplasma gondii | hypothetical protein | 0.1629 | 0.372 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0897 | 0.2012 | 0.6099 |
Echinococcus granulosus | dynactin 5 p25 | 0.007 | 0.0079 | 0.0079 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1629 | 0.372 | 0.372 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2031 | 0.4661 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.2801 | 0.6457 | 0.6361 |
Mycobacterium ulcerans | transferase | 0.0067 | 0.0073 | 0.0157 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1629 | 0.372 | 0.372 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4317 | 1 | 1 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0000062347 | 0.0000062347 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2031 | 0.4661 | 1 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.004 | 0.001 | 0.003 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0029 | 0.0029 |
Entamoeba histolytica | ankyrin, putative | 0.007 | 0.0079 | 0.0235 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1483 | 0.3381 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.001 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0294 | 0.003 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0000062347 | 0.0000062347 |
Echinococcus granulosus | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4317 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0162 | 0.0294 | 0.0294 |
Echinococcus multilocularis | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.007 | 0.0079 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4317 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1483 | 0.3381 | 0.7253 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1483 | 0.3381 | 0.3374 |
Entamoeba histolytica | acetyltransferase, putative | 0.007 | 0.0079 | 0.0235 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0000062347 | 0.0000062347 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1629 | 0.372 | 0.372 |
Echinococcus granulosus | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Echinococcus multilocularis | carbonic anhydrase | 0.1629 | 0.372 | 0.372 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1446 | 0.3293 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 820 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
IC50 (functional) | = 820 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
NT (functional) | 0 | Effective dose for in vivo ionophore-induced rat pleurisy. | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.