Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thyroid hormone receptor beta-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Thyroid hormone receptor beta-1 | 461 aa | 397 aa | 25.4 % |
Brugia malayi | nuclear hormone receptor | Thyroid hormone receptor beta-1 | 461 aa | 405 aa | 26.7 % |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | Thyroid hormone receptor beta-1 | 461 aa | 377 aa | 24.1 % |
Echinococcus multilocularis | ecdysone induced protein 78C | Thyroid hormone receptor beta-1 | 461 aa | 372 aa | 29.3 % |
Onchocerca volvulus | Thyroid hormone receptor beta-1 | 461 aa | 383 aa | 25.6 % | |
Brugia malayi | photoreceptor-specific nuclear receptor | Thyroid hormone receptor beta-1 | 461 aa | 409 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.0335 | 0.6684 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.2446 | 0.1925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 0.2446 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.024 | 0.4403 | 0.5654 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.6684 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.033 | 0.6558 | 0.9801 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0159 | 0.2446 | 0.3302 |
Echinococcus multilocularis | thymidylate synthase | 0.0335 | 0.6684 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.024 | 0.4403 | 0.5654 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.2564 | 0.215 |
Onchocerca volvulus | 0.0335 | 0.6684 | 1 | |
Onchocerca volvulus | 0.0073 | 0.0357 | 0.0534 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.024 | 0.4403 | 0.5654 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0117 | 0.1436 | 0.1705 |
Chlamydia trachomatis | dihydrofolate reductase | 0.024 | 0.4403 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.2564 | 0.215 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.2446 | 0.1179 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0117 | 0.1436 | 0.2149 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0472 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.024 | 0.4403 | 0.5654 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0117 | 0.1436 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.024 | 0.4403 | 0.5654 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.024 | 0.4403 | 0.6396 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0117 | 0.1436 | 0.1705 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0472 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.024 | 0.4403 | 0.6396 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.227 | 0.1589 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.227 | 0.1589 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0472 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.227 | 0.1589 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.024 | 0.4403 | 0.6396 |
Brugia malayi | thymidylate synthase | 0.0335 | 0.6684 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.024 | 0.4403 | 0.5654 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0335 | 0.6684 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.033 | 0.6558 | 0.9801 |
Echinococcus granulosus | thymidylate synthase | 0.0335 | 0.6684 | 1 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0117 | 0.1436 | 0.1705 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.2564 | 0.215 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.033 | 0.6558 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0472 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0335 | 0.6684 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0335 | 0.6684 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0472 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 nM | Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. | ChEMBL. | 7861417 |
IC50 (binding) | = 0.1 nM | Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. | ChEMBL. | 7861417 |
IC50 (binding) | > 5 uM | In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | ChEMBL. | 7861417 |
IC50 (binding) | > 5 uM | In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | ChEMBL. | 7861417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.