Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Integrin alpha pat-2 precursor | 0.155 | 0.6456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.3521 | 0.3521 |
Loa Loa (eye worm) | hypothetical protein | 0.1173 | 0.4861 | 0.4861 |
Echinococcus multilocularis | integrin alpha 3 | 0.1188 | 0.4928 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0695 | 0.2844 | 0.5772 |
Echinococcus granulosus | integrin alpha ps | 0.0333 | 0.1317 | 0.2672 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.1438 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.1317 | 0.1317 |
Brugia malayi | Trypsin family protein | 0.012 | 0.0416 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0105 | 0.0105 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0048 | 0.0112 | 0.0228 |
Echinococcus granulosus | integrin alpha 3 | 0.1188 | 0.4928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0072 | 0.0072 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0666 | 0.1032 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0038 | 0.0072 | 0.0146 |
Echinococcus multilocularis | integrin alpha ps | 0.0695 | 0.2844 | 0.5772 |
Loa Loa (eye worm) | integrin beta-2 | 0.0304 | 0.1194 | 0.1194 |
Brugia malayi | Kelch motif family protein | 0.0046 | 0.0105 | 0.0163 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0038 | 0.0072 | 0.0146 |
Brugia malayi | Protein kinase c protein 2 | 0.0046 | 0.0103 | 0.0159 |
Schistosoma mansoni | integrin alpha | 0.155 | 0.6456 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0054 | 0.0137 | 0.0278 |
Onchocerca volvulus | 0.012 | 0.0416 | 1 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0048 | 0.0112 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.1217 | 0.5049 | 0.5049 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0046 | 0.0105 | 0.0105 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0861 | 0.1747 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0038 | 0.0072 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0097 | 0.0097 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0861 | 0.1747 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0416 | 0.0644 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0304 | 0.1194 | 0.1849 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0105 | 0.0163 |
Onchocerca volvulus | 0.0106 | 0.0359 | 0.8644 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.004 | 0.0078 | 0.0078 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0416 | 0.0644 |
Schistosoma mansoni | integrin alpha-ps | 0.0695 | 0.2844 | 0.4406 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.1317 | 0.204 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0137 | 0.0213 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0333 | 0.1317 | 0.2672 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1173 | 0.4861 | 0.753 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0416 | 0.0416 |
Schistosoma mansoni | integrin alpha-ps | 0.0362 | 0.1438 | 0.2227 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0137 | 0.0213 |
Echinococcus granulosus | integrin alpha ps | 0.0695 | 0.2844 | 0.5772 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0054 | 0.0137 | 0.0278 |
Echinococcus multilocularis | fibrillin 1 | 0.0026 | 0.002 | 0.004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.91 uM | Binding affinity against human coagulation factor Xa | ChEMBL. | 11266180 |
Ki (binding) | = 0.91 uM | Binding affinity against human coagulation factor Xa | ChEMBL. | 11266180 |
Ki (binding) | = 5.4 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Ki (binding) | = 5.4 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Ki (binding) | = 8.5 uM | Affinity for human thrombin | ChEMBL. | 11266180 |
Ki (binding) | = 8.5 uM | Affinity for human thrombin | ChEMBL. | 11266180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.