Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0548 | 0.4172 | 0.2026 |
Onchocerca volvulus | 0.0122 | 0.0784 | 0.5916 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0124 | 0.0802 | 0.0796 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0045 | 0.0178 | 0.0171 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0029 | 0.0051 | 0.0044 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0092 | 0.0548 | 0.2961 |
Echinococcus multilocularis | tar DNA binding protein | 0.0105 | 0.0654 | 0.0648 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 0.0051 | 0.0051 |
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.1138 | 0.6192 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.0051 | 0.0497 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0045 | 0.0178 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.128 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0045 | 0.0178 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.114 | 0.8628 |
Echinococcus granulosus | geminin | 0.0136 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0124 | 0.0802 | 0.4354 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.128 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0051 | 0.0051 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0647 | 0.4961 | 0.4958 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0092 | 0.0548 | 0.2961 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0049 | 0.0466 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.0051 | 0.0497 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 0.0051 | 0.0338 |
Trichomonas vaginalis | set domain proteins, putative | 0.0189 | 0.132 | 0.69 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.0654 | 0.7239 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0051 | 0.0051 |
Echinococcus granulosus | GPCR family 2 | 0.0029 | 0.0049 | 0.0049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0029 | 0.0049 | 0.0042 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 0.0051 | 0.0497 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | ecdysteroid receptor | 0.0029 | 0.0051 | 0.0243 |
Trypanosoma brucei | protein kinase, putative | 0.0045 | 0.0178 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 0.0051 | 0.0051 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.1211 | 0.6242 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0045 | 0.0178 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0105 | 0.0654 | 0.3545 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0049 | 0.0466 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0186 | 0.1299 | 0.7073 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0369 | 0.1983 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0784 | 0.4254 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 0.0051 | 0.0497 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0784 | 0.4254 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 0.0051 | 0.0497 |
Brugia malayi | follicle stimulating hormone receptor | 0.0186 | 0.1299 | 0.7073 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0105 | 0.0654 | 0.3545 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0029 | 0.0049 | 0.0049 |
Echinococcus multilocularis | thymidine phosphorylase | 0.128 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0124 | 0.0802 | 0.0802 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0166 | 0.1138 | 0.6192 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0051 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.1211 | 0.6242 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0124 | 0.0802 | 0.8893 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0049 | 0.0466 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.0051 | 0.0243 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0548 | 0.4172 | 0.2026 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 0.0051 | 0.0051 |
Plasmodium vivax | SET domain protein, putative | 0.0024 | 0.0007 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 0.0051 | 0.0044 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0092 | 0.0548 | 0.2961 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0548 | 0.2961 |
Brugia malayi | RNA binding protein | 0.0105 | 0.0654 | 0.3545 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0045 | 0.0178 | 0.0938 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0051 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.0901 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0051 | 0.0044 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 0.0051 | 0.0497 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0049 | 0.0228 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0045 | 0.0178 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0124 | 0.0802 | 0.0802 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0029 | 0.0049 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0317 | 0.3464 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0045 | 0.0178 | 0.0178 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0029 | 0.0049 | 0.0049 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 0.0051 | 0.0497 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0124 | 0.0802 | 0.8893 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0069 | 0.0369 | 0.0362 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0317 | 0.1696 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0029 | 0.0049 | 0.0228 |
Brugia malayi | TAR-binding protein | 0.0105 | 0.0654 | 0.3545 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 0.0051 | 0.0497 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0069 | 0.0369 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.0654 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.1833 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 0.0051 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0049 | 0.0466 |
Onchocerca volvulus | 0.0189 | 0.132 | 1 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 0.0051 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0361 | 0.2692 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0105 | 0.0654 | 0.0654 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0024 | 0.0007 | 0.0007 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.0901 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0045 | 0.0178 | 0.0178 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0029 | 0.0049 | 0.0228 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0029 | 0.0049 | 0.0228 |
Loa Loa (eye worm) | RNA binding protein | 0.0105 | 0.0654 | 0.3545 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0069 | 0.0369 | 0.0369 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.0654 | 0.7239 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0369 | 0.405 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0124 | 0.0802 | 0.4354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0045 | 0.0178 | 0.0171 |
Onchocerca volvulus | 0.0029 | 0.0051 | 0.0338 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 0.0051 | 0.0497 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0045 | 0.0178 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0051 | 0.0044 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0051 | 0.0044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 0.0051 | 0.0051 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 0.0051 | 0.0497 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0051 | 0.0044 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 0.0051 | 0.0044 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0124 | 0.0802 | 0.8893 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0045 | 0.0178 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0105 | 0.0654 | 0.3545 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0045 | 0.0178 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.0051 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0051 | 0.0044 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0045 | 0.0178 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0051 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0051 | 0.0051 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 0.0051 | 0.0497 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0124 | 0.0802 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | geminin | 0.0136 | 0.0901 | 0.0895 |
Echinococcus multilocularis | GPCR, family 2 | 0.0029 | 0.0049 | 0.0042 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 0.0051 | 0.0338 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.1833 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.114 | 0.5812 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.0051 | 0.0243 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 0.0051 | 0.0044 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 0.0051 | 0.0497 |
Brugia malayi | MAP kinase sur-1 | 0.0045 | 0.0178 | 0.0938 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0178 | 0.1915 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0045 | 0.0178 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.1833 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.0654 | 0.7239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 0.0051 | 0.0243 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0063 | 0.0317 | 0.1696 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0051 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0051 | 0.0243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.0654 | 0.7239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | > 400 mg kg-1 | Dose causing 50% death of the population when tested in mice | ChEMBL. | No reference |
pA2 (functional) | = 8.1 | Concentration of the compound required to antagonize the histamine induced contractile response of guinea pig ileum | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.