Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.4 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 33.7 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 773 aa | 20.7 % |
Schistosoma japonicum | Endothelin-converting enzyme 2, putative | Neprilysin | 750 aa | 787 aa | 21.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.1497 | 0.4281 | 0.4269 |
Brugia malayi | Peptidase family M13 containing protein | 0.0228 | 0.0455 | 0.0434 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2597 | 0.7596 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0115 | 0.0115 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0228 | 0.0455 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.0276 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0183 | 0.0161 |
Echinococcus granulosus | discoidin domain receptor | 0.0086 | 0.0028 | 0.0007 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0455 | 0.0455 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.0183 | 0.0161 |
Toxoplasma gondii | hypothetical protein | 0.1087 | 0.3045 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.0115 | 0.0122 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.0276 | 0.0276 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.3395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0276 | 0.0276 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.0183 | 0.0161 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0084 | 0.0022 | 0.0022 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0228 | 0.0455 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0455 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0276 | 0.0276 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0228 | 0.0455 | 0.0434 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1497 | 0.4281 | 0.4281 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0028 | 0.0028 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.0115 | 0.0122 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0033 | 0.0011 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0115 | 0.0115 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.1087 | 0.3045 | 0.3045 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.0183 | 0.0161 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0228 | 0.0455 | 0.0434 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.0183 | 0.0212 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.0183 | 0.0161 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0472 | 0.1191 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0276 | 0.0276 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.0183 | 0.0161 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0228 | 0.0455 | 0.0572 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.3395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1087 | 0.3045 | 0.3045 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.0183 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Onchocerca volvulus | 0.0113 | 0.0108 | 1 | |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0115 | 0.0115 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0455 | 0.0455 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.3395 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0228 | 0.0455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0288 | 0.0288 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0183 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0183 | 0.0183 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.3395 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.3395 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.1087 | 0.3045 | 0.3045 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.3395 | 1 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1087 | 0.3045 | 0.3045 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0228 | 0.0455 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta blood pressure (functional) | = 25 mmHg | Compound was administered subcutaneously to spontaneously hypertensive rats (SHR) and evaluated for the ability to potentiate atrial natriuretic factor (ANF) | ChEMBL. | 2522989 |
Delta blood pressure (functional) | = 25 mmHg | Compound was administered subcutaneously to spontaneously hypertensive rats (SHR) and evaluated for the ability to potentiate atrial natriuretic factor (ANF) | ChEMBL. | 2522989 |
Delta blood pressure (functional) | = 35 mmHg | Compound was administered subcutaneously to spontaneously hypertensive rats (SHR) and evaluated for the ability to potentiate atrial natriuretic factor (ANF) | ChEMBL. | 2522989 |
Delta blood pressure (functional) | = 35 mmHg | Compound was administered subcutaneously to spontaneously hypertensive rats (SHR) and evaluated for the ability to potentiate atrial natriuretic factor (ANF) | ChEMBL. | 2522989 |
IC50 (binding) | = 11 nM | Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidney | ChEMBL. | 2522989 |
IC50 (binding) | = 11 nM | Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidney | ChEMBL. | 2522989 |
IC50 (binding) | = 15 nM | Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidney | ChEMBL. | 2522989 |
IC50 (binding) | = 15 nM | Compound was evaluated for the ability to inhibit neutral endopeptidase purified from rabbit kidney | ChEMBL. | 2522989 |
IC50 (binding) | > 1000 nM | Compound was evaluated for the ability to inhibit Angiotensin I converting enzyme in rat | ChEMBL. | 2522989 |
IC50 (binding) | > 1000 nM | Compound was evaluated for the ability to inhibit Angiotensin I converting enzyme in rat | ChEMBL. | 2522989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.