Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0028 | 0.1227 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0028 | 0.1227 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0028 | 0.1227 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1227 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0169 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0028 | 0.1227 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0028 | 0.1227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1227 | 0.1227 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0022 | 0.0829 | 0.0829 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1227 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.1227 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1227 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0022 | 0.0815 | 0.4755 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0028 | 0.1227 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1227 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0028 | 0.1227 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0442 | 0.0442 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1227 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1212 | 0.1212 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.0442 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1227 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.1227 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0028 | 0.1227 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.1227 | 1 |
Leishmania major | ABC-thiol transporter | 0.0028 | 0.1227 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0028 | 0.1227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0028 | 0.1227 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0169 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0028 | 0.1227 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.1227 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0028 | 0.1227 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0442 | 0.0442 |
Leishmania major | pentamidine resistance protein 1 | 0.0028 | 0.1227 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0028 | 0.1227 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0028 | 0.1227 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1227 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0028 | 0.1227 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0028 | 0.1227 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.1227 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.1227 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0028 | 0.1227 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.1227 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1227 | 0.1227 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0028 | 0.1227 | 0.1227 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1227 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0028 | 0.1227 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0442 | 0.0442 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.08 uM | Inhibition of platelet aggregation in canine platelet rich plasma induced by ADP | ChEMBL. | 8145226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.