Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.0048 | 0.004 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0139 | 0.0101 | 0.0094 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0356 | 0.0372 | 0.1687 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0178 | 0.0151 | 0.0349 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.1032 | 0.1214 | 0.9676 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0178 | 0.0151 | 0.0143 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0139 | 0.0101 | 0.0485 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0091 | 0.0043 | 0.0035 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0092 | 0.0044 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0091 | 0.0043 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0178 | 0.0151 | 0.0349 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0178 | 0.0151 | 0.0349 |
Plasmodium vivax | tryptophan-rich antigen (Pv-fam-a) | 0.0526 | 0.0584 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0689 | 0.0787 | 0.078 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0037 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0091 | 0.0043 | 0.0039 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.0048 | 0.004 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0178 | 0.0151 | 0.0143 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.1064 | 0.1253 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0178 | 0.0151 | 0.0349 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0356 | 0.0372 | 0.091 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0091 | 0.0043 | 0.0035 |
Brugia malayi | hypothetical protein | 0.0236 | 0.0222 | 0.0531 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0178 | 0.0151 | 0.0143 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0204 | 0.0183 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0204 | 0.0183 | 0.0176 |
Echinococcus multilocularis | nAChR subunit | 0.0091 | 0.0043 | 0.0035 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.0048 | 0.004 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0178 | 0.0151 | 0.0147 |
Entamoeba histolytica | hypothetical protein | 0.0847 | 0.0983 | 0.7765 |
Plasmodium falciparum | cation/H+ antiporter | 0.0204 | 0.0183 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0087 | 0.0037 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 0.0741 | 0.0738 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0178 | 0.0151 | 0.0349 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0139 | 0.0101 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1427 | 0.1705 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0087 | 0.0037 | 0.0061 |
Onchocerca volvulus | Putative nachr subunit | 0.0178 | 0.0151 | 0.7789 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0204 | 0.0183 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0178 | 0.0151 | 0.0349 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0139 | 0.0101 | 0.0098 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.1064 | 0.1253 | 0.3145 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.0222 | 0.0215 |
Schistosoma mansoni | nAChR subunit | 0.0087 | 0.0037 | 0.0029 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0731 | 0.0839 | 0.4597 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0204 | 0.0183 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0178 | 0.0151 | 0.0147 |
Treponema pallidum | hypothetical protein | 0.0204 | 0.0183 | 0.5 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0139 | 0.0101 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1064 | 0.1253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0178 | 0.0151 | 0.0143 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.1064 | 0.1253 | 0.7184 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.0183 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0183 | 0.018 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0689 | 0.0787 | 0.078 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0689 | 0.0787 | 0.1962 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | Cation transporter family protein | 0.0178 | 0.0151 | 0.0349 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0324 | 0.0333 | 0.2654 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0091 | 0.0043 | 0.0076 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1064 | 0.1253 | 0.1247 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0087 | 0.0037 | 0.0061 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0847 | 0.0983 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0037 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0204 | 0.0183 | 0.1159 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0087 | 0.0037 | 0.0029 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | ACC-1 protein | 0.0178 | 0.0151 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | Cation transporter family protein | 0.0178 | 0.0151 | 0.0349 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1427 | 0.1705 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0087 | 0.0037 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0013 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0052 | 0.0048 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0178 | 0.0151 | 0.0143 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.0222 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0178 | 0.0151 | 0.0143 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.0183 | 0.0509 |
Echinococcus multilocularis | sodium calcium exchanger | 0.8087 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0139 | 0.0101 | 0.2589 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1064 | 0.1253 | 0.1247 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.0048 | 0.004 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.0633 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0087 | 0.0037 | 0.0061 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0178 | 0.0151 | 0.0143 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0178 | 0.0151 | 0.0143 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0178 | 0.0151 | 0.0349 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0204 | 0.0183 | 0.0176 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0183 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 0.0787 | 0.0784 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0847 | 0.0983 | 0.7765 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0092 | 0.0044 | 0.0036 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0356 | 0.0372 | 0.2719 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0087 | 0.0037 | 0.0033 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0139 | 0.0101 | 0.0094 |
Loa Loa (eye worm) | solute carrier family 8 | 0.8087 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0178 | 0.0151 | 0.0143 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0356 | 0.0372 | 0.2967 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0204 | 0.0183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0087 | 0.0037 | 0.0033 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0087 | 0.0037 | 0.0029 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Loa Loa (eye worm) | hypothetical protein | 0.3235 | 0.3957 | 0.3955 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0204 | 0.0183 | 0.0176 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0139 | 0.0101 | 1 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0178 | 0.0151 | 0.0143 |
Onchocerca volvulus | 0.0091 | 0.0043 | 0.0405 | |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0052 | 0.0048 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0324 | 0.0333 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.0395 | 0.0392 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0178 | 0.0151 | 0.0349 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.0007 | 0.0054 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0652 | 0.0741 | 0.1845 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0204 | 0.0183 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.1064 | 0.1253 | 0.7184 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0204 | 0.0183 | 0.1693 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0087 | 0.0037 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0204 | 0.0183 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0052 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.1064 | 0.1253 | 0.7184 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0356 | 0.0372 | 0.2719 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0087 | 0.0037 | 0.0033 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0037 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0037 | 0.0061 |
Schistosoma mansoni | na/ca exchanger | 0.0204 | 0.0183 | 0.0176 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0178 | 0.0151 | 0.0143 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0087 | 0.0037 | 0.0061 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Echinococcus granulosus | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0204 | 0.0183 | 0.0431 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0139 | 0.0101 | 0.0808 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0087 | 0.0037 | 0.0029 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0178 | 0.0151 | 0.0349 |
Echinococcus multilocularis | Zinc finger, PHD finger | 0.0139 | 0.0101 | 0.0094 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0204 | 0.0183 | 0.018 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0513 | 0.0568 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0007 | 0.0054 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0139 | 0.0101 | 0.0224 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0087 | 0.0037 | 0.0029 |
Loa Loa (eye worm) | ACC-1 protein | 0.0178 | 0.0151 | 0.0147 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0087 | 0.0037 | 0.0061 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0178 | 0.0151 | 0.0143 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0037 | 0.0061 |
Onchocerca volvulus | 0.0091 | 0.0043 | 0.0405 | |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1064 | 0.1253 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0178 | 0.0151 | 0.0143 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0139 | 0.0101 | 0.0808 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0087 | 0.0037 | 0.0061 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.1064 | 0.1253 | 0.1247 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0052 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0013 | 0.0005 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0472 | 0.0516 | 0.3911 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0091 | 0.0043 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0178 | 0.0151 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.0894 | 0.0891 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0091 | 0.0043 | 0.0076 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0139 | 0.0101 | 0.0094 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0139 | 0.0101 | 0.0485 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0356 | 0.0372 | 0.1687 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0356 | 0.0372 | 0.0365 |
Brugia malayi | Cation transporter family protein | 0.0178 | 0.0151 | 0.0349 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0007 | 0.0054 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0087 | 0.0037 | 0.0029 |
Echinococcus granulosus | nAChR subunit | 0.0091 | 0.0043 | 0.0035 |
Echinococcus granulosus | phosphatidylinositol 3 kinase catalytic subunit | 0.0139 | 0.0101 | 0.0094 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0356 | 0.0372 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.0183 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0091 | 0.0043 | 0.0076 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0204 | 0.0183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0178 | 0.0151 | 0.0147 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0204 | 0.0183 | 0.0176 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0087 | 0.0037 | 0.0029 |
Echinococcus multilocularis | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0178 | 0.0151 | 0.0349 |
Schistosoma mansoni | nAChR subunit | 0.0178 | 0.0151 | 0.0143 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0178 | 0.0151 | 0.0143 |
Onchocerca volvulus | 0.0178 | 0.0151 | 0.7789 | |
Loa Loa (eye worm) | LGC-31 protein | 0.0178 | 0.0151 | 0.0147 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0037 | 0.0033 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0007 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0183 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0048 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0222 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0043 | 0.0039 |
Brugia malayi | Sodium/calcium exchanger protein | 0.3235 | 0.3957 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0178 | 0.0151 | 0.0147 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0356 | 0.0372 | 0.1687 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0087 | 0.0037 | 0.0029 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0178 | 0.0151 | 0.0143 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0204 | 0.0183 | 0.0176 |
Schistosoma mansoni | sodium/calcium exchanger | 0.8087 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0731 | 0.0839 | 0.4597 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0178 | 0.0151 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0151 | 0.0147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2100 NM | Inhibition of growth of murine leukemia (L1210) cells. | ChEMBL. | 3351855 |
ILSmax (functional) | = 73 % | The percentage increase in lifespan of compound with P388 tumor bearing controls when treated at optimal dose | ChEMBL. | 3351855 |
ILSmax (functional) | = 117 % | The percentage increase in lifespan of compound with Lewis lung carcinoma tumor bearing controls when treated at OD | ChEMBL. | 3351855 |
Log K (binding) | = 5.61 | Binding constant for DNA by ethidium bromide displacement | ChEMBL. | 3351855 |
Log K (binding) | = 5.9 | Binding constant for DNA by ethidium bromide displacement | ChEMBL. | 3351855 |
OD (functional) | = 100 mg kg-1 day-1 | Optimal dose following i.p. administration on days 1,5 and 9 after inoculation of 10e6 P388 leukemia cells to mice. | ChEMBL. | 3351855 |
OD (functional) | = 150 mg kg-1 day-1 | Optimal dose of the compound administered intraperitoneally to mice infected with Lewis lung carcinoma cells(LL) in vivo | ChEMBL. | 3351855 |
pKa | = 2.95 | pKa of the compound was evaluated | ChEMBL. | 3351855 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.