Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | POT family protein | 0.0082 | 0.0311 | 0.0311 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0486 | 0.2786 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0359 | 0.2008 | 0.2008 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0118 | 0.0531 | 0.0531 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0118 | 0.0531 | 0.1907 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0056 | 0.0146 | 0.0146 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0056 | 0.0056 |
Schistosoma mansoni | ets-related | 0.0218 | 0.114 | 0.4093 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0083 | 0.0083 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0118 | 0.0531 | 0.1907 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.2008 | 0.2008 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0083 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0083 | 0.0083 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0245 | 0.1309 | 0.47 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0486 | 0.2786 | 0.5 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0058 | 0.0162 | 0.0581 |
Schistosoma mansoni | neprilysin | 0.0127 | 0.0583 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2786 | 0.2786 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0118 | 0.0531 | 0.1907 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0118 | 0.0531 | 0.1907 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0083 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.2008 | 0.2008 |
Brugia malayi | Fli-1 protein | 0.0218 | 0.114 | 0.114 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0486 | 0.2786 | 1 |
Onchocerca volvulus | 0.0035 | 0.0018 | 0.0138 | |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1282 | 0.1282 |
Brugia malayi | calpain family protein 1 | 0.0056 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2786 | 0.2786 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0162 | 0.0581 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0486 | 0.2786 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.0486 | 0.2786 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0245 | 0.0245 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0245 | 0.1309 | 0.47 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0486 | 0.2786 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Brugia malayi | peptidase family M13 containing protein | 0.0118 | 0.0531 | 0.0531 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0245 | 0.1309 | 0.47 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.0146 | 0.0525 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0083 | 0.0298 |
Onchocerca volvulus | 0.0241 | 0.1282 | 1 | |
Loa Loa (eye worm) | fli-1 protein | 0.0218 | 0.114 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0181 | 0.0181 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0486 | 0.2786 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0083 | 0.0298 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0041 | 0.0056 | 0.0202 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0245 | 0.1309 | 0.47 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.0245 | 0.088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0083 | 0.0298 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0083 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.206 | 0.206 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0118 | 0.0531 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0146 | 0.0146 |
Brugia malayi | Peptidase family M13 containing protein | 0.0486 | 0.2786 | 0.2786 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0359 | 0.2008 | 0.2008 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0118 | 0.0531 | 0.1907 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0162 | 0.0581 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0083 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.2008 | 0.2008 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0245 | 0.1309 | 0.47 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.2008 | 0.2008 |
Brugia malayi | POT family protein | 0.0082 | 0.0311 | 0.0311 |
Brugia malayi | calpain family protein 1 | 0.0056 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0583 | 0.2094 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1663 | 1 | 1 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.0245 | 0.088 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0041 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2786 | 0.2786 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0127 | 0.0583 | 0.2094 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.0245 | 0.088 |
Echinococcus granulosus | calpain A | 0.0058 | 0.0162 | 0.0581 |
Echinococcus multilocularis | calpain A | 0.0058 | 0.0162 | 0.0581 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0486 | 0.2786 | 0.2786 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0162 | 0.0581 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 ug ml-1 | In vitro inhibitory activity against prostaglandin G/H synthase 2 using mouse peritoneal macrophage method | ChEMBL. | 14761182 |
IC50 (binding) | = 0.2 ug ml-1 | In vitro inhibitory activity against prostaglandin G/H synthase 2 using mouse peritoneal macrophage method | ChEMBL. | 14761182 |
IC50 (binding) | = 0.2 ug ml-1 | Inhibition of COX2 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs before LPS stimulation for 16 hrs followed by arachidonic acid addition and measured after 10 mins in presence of 500 uM aspirin by radio-immuno assay or enzyme-immunoassay | PATENT. | No reference |
IC50 (binding) | = 30 ug ml-1 | In vitro inhibitory activity against prostaglandin G/H synthase 1 using mouse peritoneal macrophage method | ChEMBL. | 14761182 |
IC50 (binding) | = 30 ug ml-1 | In vitro inhibitory activity against prostaglandin G/H synthase 1 using mouse peritoneal macrophage method | ChEMBL. | 14761182 |
IC50 (binding) | = 30 ug ml-1 | Inhibition of COX1 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs followed by arachidonic acid addition and measured after 10 mins by radio-immuno assay or enzyme-immunoassay | PATENT. | No reference |
Selectivity (binding) | = 150 | Selectivity of the compound against COX-2 over COX-1 | ChEMBL. | 14761182 |
Selectivity (binding) | = 150 | Selectivity of the compound against COX-2 over COX-1 | ChEMBL. | 14761182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.