Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0198 | 0.0198 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.2401 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2401 | 0.2401 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0198 | 0.0198 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0383 | 0.5604 | 0.5604 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.156 | 0.65 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.2401 | 0.2401 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.156 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.2401 | 0.2401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0198 | 0.0198 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0198 | 0.0198 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.2401 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0198 | 0.0198 |
Onchocerca volvulus | 0.0645 | 1 | 1 | |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0645 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.2401 | 0.2401 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.2401 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.2401 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0198 | 0.0198 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.2401 | 0.2401 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.2401 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0262 | 0.3555 | 0.3555 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0198 | 0.0198 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0645 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.2401 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0198 | 0.0198 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.2401 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.2401 | 0.2401 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0198 | 0.0198 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0198 | 0.0198 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0645 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0198 | 0.0198 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0198 | 0.0198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 123 nM | Concentration required for the inhibitory activity against human Farnesyltransferase | ChEMBL. | 11294379 |
IC50 (binding) | = 123 nM | Concentration required for the inhibitory activity against human Farnesyltransferase | ChEMBL. | 11294379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.