Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0733 | 0.0841 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0993 | 0.1139 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0063 | 0.2441 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1198 | 0.3419 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1198 | 0.3419 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.8719 | 0.8719 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 0.8719 | 0.8719 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.0309 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0309 | 0.0309 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0309 | 0.0309 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.3108 | 0.3108 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0733 | 0.0841 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0309 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.1198 | 0.1374 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.3108 | 0.3564 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.1098 | 0.1098 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.3108 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.0309 | 0.0355 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.1098 | 0.1098 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0309 | 0.0355 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.3108 | 0.3564 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1748 | 0.2005 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.8719 | 1 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0309 | 0.0309 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0309 | 0.0309 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.041 | 0.0471 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0733 | 0.0733 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0993 | 0.1139 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0993 | 0.2714 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.7626 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.8719 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0309 | 0.0355 |
Onchocerca volvulus | 0.0032 | 0.041 | 0.0471 | |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0733 | 0.0733 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 0.8719 | 0.8719 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0309 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0309 | 0.0355 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.4891 | 0.4891 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0158 | 0.8719 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0309 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.3535 | 0.3535 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.0309 | 0.0309 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0309 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.8719 | 0.8719 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0063 | 0.2441 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.3108 | 0.3108 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.2453 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0993 | 0.1139 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0993 | 0.2714 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.8719 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.3108 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.4891 | 0.4891 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.4891 | 0.5609 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.7 nM | Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrate | ChEMBL. | No reference |
IC50 (binding) | = 8.7 nM | Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrate | ChEMBL. | No reference |
IC50 (binding) | = 8.7 nM | Inhibition of pig kidney POP | ChEMBL. | 20058865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.