Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pten, drome, putative | 0.0057 | 0.0285 | 0.5 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0057 | 0.0285 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0078 | 0.0461 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0296 | 0.2327 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0061 | 0.032 | 0.0036 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0078 | 0.0461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0078 | 0.0461 | 0.0181 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0296 | 0.2327 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0296 | 0.2327 | 0.2102 |
Loa Loa (eye worm) | protein-tyrosine phosphatase 1 | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | dual specificity protein phosphatase CDC14B | 0.0057 | 0.0285 | 0.0285 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0611 | 0.5023 | 0.4877 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1192 | 1 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0061 | 0.032 | 0.0036 |
Loa Loa (eye worm) | protein tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine-phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0061 | 0.032 | 0.0036 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0057 | 0.0285 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0082 | 0.0496 | 0.0496 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0078 | 0.0461 | 0.0181 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0082 | 0.0496 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0082 | 0.0496 | 0.0217 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0296 | 0.2327 | 0.2327 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0085 | 0.0525 | 0.0247 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0296 | 0.2327 | 0.2102 |
Onchocerca volvulus | 0.0078 | 0.0461 | 1 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0085 | 0.0525 | 0.0247 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0085 | 0.0525 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0078 | 0.0461 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0057 | 0.0285 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0085 | 0.0525 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0611 | 0.5023 | 0.4877 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0082 | 0.0496 | 0.0217 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0057 | 0.0285 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0085 | 0.0525 | 0.0247 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0296 | 0.2327 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0085 | 0.0525 | 0.0247 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0078 | 0.0461 | 0.0181 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1192 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0296 | 0.2327 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1192 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0078 | 0.0461 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0082 | 0.0496 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0006 | 0.0006 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0061 | 0.032 | 0.0036 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0057 | 0.0285 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0061 | 0.032 | 0.0036 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0615 | 0.5058 | 0.4913 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0057 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0285 | 0.0285 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0061 | 0.032 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C/I ratio (functional) | = 0 | In vivo activity against microsporosis guinea pig, measured as the ratio of animals cured/animals infected (C/I) at dose 1.25 mg/kg; 0/4 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 1 | In vivo activity against vaginal candidoses in rats, measured as the ratio of animals cured/animals infected (C/I) at dose 1.25 mg/kg; 1/2 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 1 | In vivo activity against vaginal candidoses in rats, measured as the ratio of animals cured/animals infected (C/I) at dose 0.63 mg/kg; 1/6 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 2 | In vivo activity against microsporosis guinea pig, measured as the ratio of animals cured/animals infected (C/I) at dose 10 mg/kg; 2/2 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 3 | In vivo activity against vaginal candidoses in rats, measured as the ratio of animals cured/animals infected (C/I) at dose 2.5 mg/kg; 3/6 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 4 | In vivo activity against microsporosis guinea pig, measured as the ratio of animals cured/animals infected (C/I) at dose 2.5 mg/kg; 4/6 | ChEMBL. | 6330360 |
Inhibition (functional) | = 1 % | In vitro antifungal activity against Trichophyton mentagrophytes | ChEMBL. | 6330360 |
Inhibition (functional) | = 1 % | In vitro antifungal activity against Candida tropicalis | ChEMBL. | 6330360 |
Inhibition (functional) | = 10 % | In vitro antifungal activity against Trichophyton rubrum | ChEMBL. | 6330360 |
Inhibition (functional) | = 10 % | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | = 10 % | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Microsporum canis | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Phialophora verrucosa | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Mucor sp | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Aspergillus fumigatus | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 % | In vitro antifungal activity against Sporothrix schenck ii | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Saprolegnia sp | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 % | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.