Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ras gtpase | 0.0265 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.2458 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.2458 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.2458 | 0.2458 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0063 | 0.1066 | 0.1066 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0.1066 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.2458 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0063 | 0.1066 | 0.1066 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0.1066 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0063 | 0.1066 | 0.1066 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.2458 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.2458 | 0.5 |
Trichomonas vaginalis | rheb, putative | 0.0265 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0063 | 0.1066 | 0.1066 |
Onchocerca volvulus | 0.0063 | 0.1066 | 1 | |
Entamoeba histolytica | ras-1, putative | 0.0265 | 1 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.2458 | 0.2458 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.2458 | 0.1558 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.2458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0265 | 1 | 0.5 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0265 | 1 | 1 |
Trichomonas vaginalis | rap1 and, putative | 0.0265 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0063 | 0.1066 | 0.1066 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.2458 | 0.1558 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.2458 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.2208 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0063 | 0.1066 | 0.1066 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.2208 | 0.8869 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0063 | 0.1066 | 0.1066 |
Trichomonas vaginalis | dexras1, putative | 0.0265 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0063 | 0.1066 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | nuclear receptor NHR-88 | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0063 | 0.1066 | 0.1066 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.2458 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0265 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.1066 | 0.1066 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.2208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.2458 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.046 | 0.0954 |
Trichomonas vaginalis | ral, putative | 0.0265 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.2458 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0265 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Echinococcus multilocularis | ras gtpase | 0.0265 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0265 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.1066 | 0.1066 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.2458 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.2458 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.2458 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0063 | 0.1066 | 0.1066 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0063 | 0.1066 | 0.1066 |
Entamoeba histolytica | Ras family GTPase | 0.0265 | 1 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.2458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0063 | 0.1066 | 0.1066 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.2458 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 uM | Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II) | ChEMBL. | 12657262 |
IC50 (binding) | = 0.5 uM | Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II) | ChEMBL. | 12657262 |
IC50 (functional) | > 10 uM | Inhibition of CEM T-cell proliferation | ChEMBL. | 12657262 |
IC50 (functional) | > 10 uM | Inhibition of CEM T-cell proliferation | ChEMBL. | 12657262 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12657262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.