Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0497 | 0.5499 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0869 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0288 | 0.2957 | 0.2575 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.2091 | 0.295 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0494 | 0.5453 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0604 | 0.6797 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0494 | 0.5453 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0497 | 0.5499 | 0.7241 |
Loa Loa (eye worm) | thymidylate kinase | 0.0216 | 0.2091 | 0.2683 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0216 | 0.2091 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0497 | 0.5499 | 0.7981 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0497 | 0.5499 | 0.7241 |
Toxoplasma gondii | thymidylate kinase | 0.0216 | 0.2091 | 0.2091 |
Brugia malayi | dihydrofolate reductase family protein | 0.0497 | 0.5499 | 0.809 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0288 | 0.2957 | 0.2586 |
Schistosoma mansoni | thymidylate kinase | 0.0216 | 0.2091 | 0.295 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0216 | 0.2091 | 0.2683 |
Onchocerca volvulus | 0.0604 | 0.6797 | 1 | |
Leishmania major | thymidylate kinase-like protein | 0.0216 | 0.2091 | 0.1675 |
Brugia malayi | thymidylate kinase | 0.0216 | 0.2091 | 0.3077 |
Schistosoma mansoni | dihydrofolate reductase | 0.0497 | 0.5499 | 0.8055 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0216 | 0.2091 | 0.1675 |
Trypanosoma brucei | thymidine kinase | 0.0494 | 0.5453 | 0.425 |
Trypanosoma brucei | RNA helicase, putative | 0.0273 | 0.2781 | 0.0872 |
Schistosoma mansoni | thymidylate kinase | 0.0216 | 0.2091 | 0.295 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0869 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0604 | 0.6797 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0869 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0604 | 0.6797 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0497 | 0.5499 | 0.8055 |
Giardia lamblia | Thymidine kinase | 0.0494 | 0.5453 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0494 | 0.5453 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0869 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0497 | 0.5499 | 0.809 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0288 | 0.2957 | 0.1839 |
Brugia malayi | hypothetical protein | 0.0288 | 0.2957 | 0.435 |
Echinococcus granulosus | thymidylate kinase | 0.0216 | 0.2091 | 0.295 |
Plasmodium vivax | thymidylate kinase, putative | 0.0216 | 0.2091 | 0.2091 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0604 | 0.6797 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0494 | 0.5453 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0216 | 0.2091 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0604 | 0.6797 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0494 | 0.5453 | 0.5213 |
Loa Loa (eye worm) | thymidylate synthase | 0.0604 | 0.6797 | 1 |
Leishmania major | thymidine kinase, putative | 0.0494 | 0.5453 | 0.5213 |
Mycobacterium ulcerans | thymidylate synthase | 0.0604 | 0.6797 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0497 | 0.5499 | 0.8055 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0216 | 0.2091 | 0.1675 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0497 | 0.5499 | 0.7241 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.2781 | 0.3983 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0494 | 0.5453 | 0.5213 |
Echinococcus multilocularis | thymidylate kinase | 0.0216 | 0.2091 | 0.295 |
Brugia malayi | thymidylate synthase | 0.0604 | 0.6797 | 1 |
Giardia lamblia | CDC8 | 0.0216 | 0.2091 | 0.3809 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0869 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at muscarinic acetylcholine receptor M3; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M1; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 3 | Subtype selectivity and cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M4; Activity range is 1.2-3 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 3 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M2; Activity range is 1.2-3 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at muscarinic acetylcholine receptor M3; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M1; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 3 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M2; Activity range is 1.2-3 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 3 | Subtype selectivity and cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M4; Activity range is 1.2-3 | ChEMBL. | 11881995 |
Log 1/M (binding) | = 4.86 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.14 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.68 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.92 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.13 | Logarithm of affinity (log 1/M) at the free muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.17 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.18 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 4.86 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.14 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.68 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.92 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.13 | Logarithm of affinity (log 1/M) at the free muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.17 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.18 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.