Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0913 | 0.0758 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0913 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.8099 | 0.8067 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0028 | 0.1463 | 0.1318 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0081 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.259 | 0.259 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.259 | 0.259 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0081 | 1 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0028 | 0.1463 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0081 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.6921 | 0.6921 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.6354 | 0.6354 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0028 | 0.1463 | 0.1463 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0167 | 0.0167 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1463 | 0.1318 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2976 | 0.2857 |
Loa Loa (eye worm) | calcium channel | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3654 | 0.3546 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0028 | 0.1463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3351 | 0.3238 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0081 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.047 | 0.047 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0081 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.2965 | 0.2316 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.047 | 0.047 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.6354 | 0.6354 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0081 | 1 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0081 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0081 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.8777 | 0.8664 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0028 | 0.1463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0081 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0081 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0081 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 529 nM | In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor. | ChEMBL. | 10715156 |
IC50 (binding) | = 529 nM | In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor. | ChEMBL. | 10715156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.