Detailed information for compound 301380

Basic information

Technical information
  • TDR Targets ID: 301380
  • Name: 4-[2-(4-cyclohexylanilino)-1,3-thiazol-4-yl]- 5-methylsulfanylthiophene-2-carboximidamide
  • MW: 428.637 | Formula: C21H24N4S3
  • H donors: 2 H acceptors: 1 LogP: 6.85 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1sc(cc1c1csc(n1)Nc1ccc(cc1)C1CCCCC1)C(=N)N
  • InChi: 1S/C21H24N4S3/c1-26-20-16(11-18(28-20)19(22)23)17-12-27-21(25-17)24-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h7-13H,2-6H2,1H3,(H3,22,23)(H,24,25)
  • InChiKey: NELHQWBZKJRQAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(4-cyclohexylanilino)thiazol-4-yl]-5-methylsulfanyl-thiophene-2-carboxamidine
  • 4-[2-(4-cyclohexylanilino)-4-thiazolyl]-5-(methylthio)-2-thiophenecarboxamidine
  • 4-[2-[(4-cyclohexylphenyl)amino]-1,3-thiazol-4-yl]-5-methylsulfanyl-thiophene-2-carboximidamide
  • 4-[2-(4-cyclohexylanilino)thiazol-4-yl]-5-(methylthio)thiophene-2-carboxamidine
  • 4-[2-[(4-cyclohexylphenyl)amino]-1,3-thiazol-4-yl]-5-methylsulfanylthiophene-2-carboximidamide
  • 4-[2-[(4-cyclohexylphenyl)amino]thiazol-4-yl]-5-methylsulfanyl-thiophene-2-carboxamidine
  • 4-[2-[(4-cyclohexylphenyl)amino]-4-thiazolyl]-5-(methylthio)-2-thiophenecarboxamidine
  • 4-[2-[(4-cyclohexylphenyl)amino]thiazol-4-yl]-5-(methylthio)thiophene-2-carboxamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0067 0.0183
Echinococcus multilocularis nmda type glutamate receptor 0.0137 0.0459 0.1362
Echinococcus multilocularis Squalene phytoene synthase 0.0077 0.0184 0.0534
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0067 0.0183
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0052 0.0071 0.0016
Echinococcus multilocularis NMDA receptor 0.0129 0.0419 0.1242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.0768 0.333 1
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.0071 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0067 0.0183
Echinococcus granulosus vesicular acetylcholine transporter 0.0657 0.2823 0.8477
Brugia malayi Metabotropic glutamate receptor precursor. 0.0052 0.0071 0.0065
Brugia malayi GnHR receptor homolog 0.0051 0.0067 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0065 0.0065
Mycobacterium ulcerans phytoene synthase, CrtB 0.0077 0.0184 0.2767
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0281 0.1112 0.3327
Schistosoma mansoni metabotropic glutamate receptor 0.0052 0.0071 0.0196
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0067 0.0183
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni myosin xvIII 0.0051 0.0067 0.0183
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0111 0.0337 0.0337
Echinococcus multilocularis nmda type glutamate receptor 0.0393 0.162 0.4857
Leishmania major hypothetical protein, conserved 0.0077 0.0184 0.0178
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0067 0.0067
Schistosoma mansoni glutamate receptor kainate 0.0229 0.0874 0.2612
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1034 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0065 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0179 0.0648 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) glutamate receptor 0.0052 0.0071 0.0071
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0028 0.0067
Echinococcus multilocularis glutamate receptor 2 0.0152 0.0527 0.1566
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0067 0.0183
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2234 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0067 0.0061
Echinococcus multilocularis serotonin transporter 0.009 0.0243 0.0712
Schistosoma mansoni glutamate receptor kainate 0.0229 0.0874 0.2612
Trypanosoma cruzi phytoene synthase, putative 0.0077 0.0184 0.0178
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0657 0.2823 0.2823
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0067 0.0183
Schistosoma mansoni biogenic amine receptor 0.0051 0.0067 0.0183
Echinococcus granulosus tyrosine kinase 0.0052 0.0071 0.0196
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0067 0.0183
Schistosoma mansoni transient receptor potential channel 0.0074 0.0171 0.0495
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis glutamate receptor NMDA 0.0085 0.0221 0.0647
Schistosoma mansoni opsin-like receptor 0.0051 0.0067 0.0183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0067 0.0183
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0031 0.0075
Brugia malayi Guanylyl cyclase protein 23 0.0052 0.0071 0.0065
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Schistosoma mansoni opsin-like receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni transient receptor potential channel 0.0074 0.0171 0.0495
Schistosoma mansoni amine GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0052 0.0071 0.0071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0067 0.0183
Brugia malayi Sodium:neurotransmitter symporter family protein 0.009 0.0243 0.0237
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0071 0.0071
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Brugia malayi Serotonin receptor 0.0051 0.0067 0.0061
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0052 0.0071 0.0196
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0067 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus g protein coupled receptor 0.0051 0.0067 0.0183
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0028 0.0028
Echinococcus granulosus orexin receptor type 2 0.0051 0.0067 0.0183
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0052 0.0071 0.0071
Onchocerca volvulus 0.0264 0.1034 0.3507
Echinococcus granulosus fmrfamide receptor 0.0051 0.0067 0.0183
Brugia malayi sulfakinin receptor protein 0.0051 0.0067 0.0061
Schistosoma mansoni sodium/chloride dependent transporter 0.009 0.0243 0.0712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0065 0.0178
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0006 0.5
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0129 0.0419 0.1242
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis serotonin receptor 0.0051 0.0067 0.0183
Schistosoma mansoni tyrosine kinase 0.0052 0.0071 0.0196
Schistosoma mansoni glutamate receptor kainate 0.0229 0.0874 0.2612
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0179 0.0648 1
Echinococcus granulosus glutamate receptor 2 0.0281 0.1112 0.3327
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0067 0.0067
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0067 0.0183
Brugia malayi AKH receptor 0.0051 0.0067 0.0061
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0067 0.0183
Entamoeba histolytica hypothetical protein 0.0052 0.0071 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni metabotropic glutamate receptor 0.0052 0.0071 0.0196
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0657 0.2823 1
Schistosoma mansoni neuropeptide receptor 0.0051 0.0067 0.0183
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0067 0.0183
Schistosoma mansoni adenoreceptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0031 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0067 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0065 0.0178
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0067 0.0183
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus serotonin receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0067 0.0183
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0067 0.0183
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0031 0.0075
Brugia malayi G-protein coupled receptor 0.0051 0.0067 0.0061
Schistosoma mansoni hypothetical protein 0.0051 0.0067 0.0183
Echinococcus multilocularis transient receptor potential gamma protein 0.0111 0.0337 0.0996
Leishmania major C-8 sterol isomerase-like protein 0.2234 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0067 0.0183
Onchocerca volvulus 0.0052 0.0071 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0067 0.0183
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.009 0.0243 0.0712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni amine GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0575 0.2453 0.7361
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus metabotropic glutamate receptor 5 0.0052 0.0071 0.0196
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0067 0.0061
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0129 0.0419 0.1242
Echinococcus granulosus transient receptor potential gamma protein 0.0111 0.0337 0.0996
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0067 0.0183
Brugia malayi Dopamine receptor protein 1 0.0051 0.0067 0.0061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 0.0067 0.0067
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0067 0.0183
Echinococcus granulosus sex peptide receptor 0.0051 0.0067 0.0183
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0067 0.0183
Echinococcus granulosus g protein coupled receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0065 0.0178
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis glutamate receptor 2 0.0281 0.1112 0.3327
Brugia malayi G protein-coupled receptor 0.0051 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Brugia malayi RE15519p 0.0051 0.0067 0.0061
Schistosoma mansoni glutamate receptor NMDA 0.0366 0.1499 0.4493
Brugia malayi follicle stimulating hormone receptor 0.0051 0.0067 0.0061
Onchocerca volvulus 0.0052 0.0071 0.0016
Echinococcus granulosus geminin 0.017 0.0607 0.1809
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0281 0.1112 0.3327
Echinococcus multilocularis microtubule associated protein 2 0.0768 0.333 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0184 0.0184
Brugia malayi Serotonin receptor 0.0051 0.0067 0.0061
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0077 0.0184 0.0423
Echinococcus multilocularis glutamate receptor 2 0.0229 0.0874 0.2612
Echinococcus granulosus allatostatin A receptor 0.0051 0.0067 0.0183
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0067 0.0061
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0028 0.0022
Schistosoma mansoni amine GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0067 0.0183
Echinococcus granulosus nmda type glutamate receptor 0.0393 0.162 0.4857
Leishmania major squalene synthase, putative 0.0247 0.0957 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0067 0.0183
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0067 0.0183
Echinococcus granulosus glutamate receptor NMDA 0.0085 0.0221 0.0647
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0048 0.0125
Echinococcus granulosus neuropeptide receptor 0.0051 0.0067 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Chlamydia trachomatis glutamine binding protein 0.0179 0.0648 0.5
Schistosoma mansoni neuropeptide receptor 0.0051 0.0067 0.0183
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0067 0.0183
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0179 0.0648 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0067 0.0183
Schistosoma mansoni vesicular acetylcholine transporter 0.0657 0.2823 0.8477
Schistosoma mansoni glutamate receptor AMPA 0.0229 0.0874 0.2612
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0067 0.0183
Trypanosoma cruzi squalene synthase, putative 0.0247 0.0957 0.0951
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0067 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus microtubule associated protein 2 0.0768 0.333 1
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0067 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis somatostatin receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis vesicular acetylcholine transporter 0.0657 0.2823 0.8477
Brugia malayi Dopamine receptor 0.0051 0.0067 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0048 0.0125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0067 0.0061
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0051 0.0067 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0065 0.0178
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0067 0.0183
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0281 0.1112 0.3327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0065 0.0178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0067 0.0183
Trypanosoma brucei C-8 sterol isomerase, putative 0.2234 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0067 0.0183
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0065 0.0178
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis serotonin receptor 0.0051 0.0067 0.0183
Echinococcus granulosus atrial natriuretic peptide receptor 0.0052 0.0071 0.0196
Brugia malayi neuropeptide F receptor 0.0051 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0067 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0067 0.0183
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0067 0.0183
Treponema pallidum sodium- and chloride- dependent transporter 0.009 0.0243 0.3686
Schistosoma mansoni neuropeptide receptor 0.0051 0.0067 0.0183
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0129 0.0419 0.1242
Schistosoma mansoni hypothetical protein 0.0051 0.0067 0.0183
Brugia malayi putative neuropeptide receptor 0.0051 0.0067 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus serotonin transporter 0.009 0.0243 0.0712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0067 0.0067
Echinococcus granulosus transient receptor potential ion channel A 0.0104 0.0309 0.0911
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0307 0.1233 0.3691
Brugia malayi Glutamate receptor 2 precursor 0.0229 0.0874 0.0869
Echinococcus granulosus somatostatin receptor 0.0051 0.0067 0.0183
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0171 0.0495
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0281 0.1112 0.3327
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0067 0.0183
Schistosoma mansoni amine GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis sex peptide receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.2234 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0006 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0006 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0137 0.0459 0.1362
Schistosoma mansoni glutamate receptor AMPA 0.0229 0.0874 0.2612
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0067 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni ATP-binding cassette transporter 0.0229 0.0874 0.2612
Loa Loa (eye worm) solute carrier family 6 member 4 0.009 0.0243 0.0243
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis receptor type guanylyl cyclase 0.0052 0.0071 0.0196
Schistosoma mansoni opsin-like receptor 0.0051 0.0067 0.0183
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis geminin 0.017 0.0607 0.1809
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0068 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Brugia malayi G-protein coupled receptor 0.0051 0.0067 0.0061
Schistosoma mansoni transient receptor potential channel 0.0111 0.0337 0.0996
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0067 0.0067
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0129 0.0419 0.1242
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0052 0.0071 0.0196
Brugia malayi Melatonin receptor type 1A 0.0051 0.0067 0.0061
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0171 0.0495
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0067 0.0183
Schistosoma mansoni hypothetical protein 0.0129 0.0419 0.1242
Schistosoma mansoni glutamate receptor NMDA 0.0467 0.1959 0.5877
Echinococcus granulosus receptor type guanylyl cyclase 0.0052 0.0071 0.0196
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0067 0.0183
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0067 0.0183
Leishmania major extracellular receptor, putative 0.0052 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0052 0.0071 0.0065
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Loa Loa (eye worm) glutamate receptor 2 0.0229 0.0874 0.0874
Loa Loa (eye worm) serotonin transporter b 0.009 0.0243 0.0243
Echinococcus granulosus Squalene phytoene synthase 0.0077 0.0184 0.0534
Brugia malayi ORL1-like opioid receptor 0.0051 0.0067 0.0061
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0129 0.0419 0.1242
Echinococcus multilocularis transient receptor potential ion channel A 0.0104 0.0309 0.0911
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0067 0.0183
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0171 0.0495
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni biogenic amine receptor 0.0051 0.0067 0.0183
Schistosoma mansoni histamine h1 receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0171 0.0495
Echinococcus granulosus glutamate receptor 2 0.0152 0.0527 0.1566
Brugia malayi metabotropic glutamate receptor type 2 0.0052 0.0071 0.0065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) norepinephrine transporter 0.009 0.0243 0.0243
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0281 0.1112 0.3327
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0052 0.0071 0.0196
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0067 0.0183
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Trypanosoma cruzi squalene synthase, putative 0.0247 0.0957 0.0951
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0129 0.0419 0.1242
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0028 0.0067
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Brugia malayi larval opioid receptor 0.0051 0.0067 0.0061
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0067 0.0183
Toxoplasma gondii exonuclease III APE 0.0038 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0067 0.0183
Onchocerca volvulus 0.009 0.0243 0.0637
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0281 0.1112 0.3327
Brugia malayi hypothetical protein 0.0052 0.0071 0.0065
Loa Loa (eye worm) glutamate receptor 1 0.0229 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0281 0.1112 0.3327
Loa Loa (eye worm) hypothetical protein 0.1142 0.503 0.503
Echinococcus granulosus metabotropic glutamate receptor 2 0.0052 0.0071 0.0196
Echinococcus granulosus g protein coupled receptor 0.0051 0.0067 0.0183
Trypanosoma brucei squalene synthase, putative 0.0247 0.0957 0.0951
Schistosoma mansoni hypothetical protein 0.0077 0.0184 0.0534
Brugia malayi vesicular acetylcholine transporter unc-17 0.0657 0.2823 0.2819
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0067 0.0183
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0067 0.0061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0281 0.1112 0.3327
Loa Loa (eye worm) hypothetical protein 0.009 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.017 0.0607 0.1809
Echinococcus granulosus neuropeptide receptor 0.0051 0.0067 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0067 0.0067
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0067 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0065 0.0059
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.0071 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0575 0.2453 0.7361
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0067 0.0183
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0067 0.0183
Echinococcus granulosus glutamate receptor subunit protein glur 0.0129 0.0419 0.1242
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus granulosus hypothetical protein 0.0051 0.0067 0.0183
Schistosoma mansoni hypothetical protein 0.0051 0.0067 0.0183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0067 0.0183
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0006 0.0032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.009 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0067 0.0061
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0067 0.0183
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0467 0.1959 0.5877
Echinococcus granulosus glutamate NMDA receptor subunit 0.0467 0.1959 0.5877
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Trypanosoma cruzi extracellular receptor, putative 0.0052 0.0071 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.0888 0.0888
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0179 0.0648 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Schistosoma mansoni protein kinase 0.0052 0.0071 0.0196
Brugia malayi Pre-SET motif family protein 0.0232 0.0888 0.0882
Schistosoma mansoni amine GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0067 0.0183
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0067
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0067 0.0183
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0006 0.5
Schistosoma mansoni hypothetical protein 0.017 0.0607 0.1809
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0052 0.0071 0.0071
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0067 0.0183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0071
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0067 0.0183
Echinococcus multilocularis tyrosine kinase 0.0052 0.0071 0.0196
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0179 0.0648 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0243 0.0243
Brugia malayi neuropeptide F receptor 0.0051 0.0067 0.0061
Schistosoma mansoni neuropeptide receptor 0.0051 0.0067 0.0183
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0077 0.0184 0.2767
Brugia malayi Glutamate receptor 1 precursor 0.0229 0.0874 0.0869
Brugia malayi Dopamine receptor protein 2 0.0051 0.0067 0.0061
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0067 0.0183
Schistosoma mansoni biogenic amine receptor 0.0051 0.0067 0.0183
Schistosoma mansoni tyrosine kinase 0.0052 0.0071 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0067 0.0183
Brugia malayi hypothetical protein 0.0051 0.0067 0.0061
Schistosoma mansoni transient receptor potential channel 4 0.0111 0.0337 0.0996
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0067 0.0183

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.11 uM In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa) ChEMBL. 11294390
Ki (binding) = 0.11 uM In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa) ChEMBL. 11294390

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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