TDR Targets

Basic information

Technical information

TDR Targets ID: 304656
Name: (2R,3R,4S,5R)-2-(4-aminoimidazo[4,5-d]triazin -7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
MW: 268.229 | Formula: C9H12N6O4
H donors: 4 H acceptors: 7 LogP: -2.81 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nnnc2N
InChi: 1S/C9H12N6O4/c10-7-4-8(13-14-12-7)15(2-11-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H2,10,12,13)/t3-,5-,6-,9-/m1/s1
InChiKey: JNGWKCBNKZBPLB-UUOKFMHZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3R,4S,5R)-2-(4-aminoimidazo[4,5-d]triazin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(4-amino-7-imidazo[4,5-d]triazinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(4-azanylimidazo[4,5-d][1,2,3]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(4-aminoimidazo[4,5-d]triazin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
2-azaadenosine
(2R,3R,4S,5R)-2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(4-amino-7-imidazo[5,4-d]triazinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(4-aminoimidazo[5,4-d][1,2,3]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
7H-Imidazo(4,5-d)-1,2,3-triazin-4-amine, 7-beta-D-ribofuranosyl-
NSC 125640

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ribonuclease H1, putative	0.0235	0.2568	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Echinococcus granulosus	geminin	0.0138	0.1448	0.3044
Echinococcus granulosus	lamin	0.0022	0.0117	0.017
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.002	0.0095	0.0122
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0235	0.2568	0.5
Brugia malayi	reverse transcriptase	0.002	0.0095	0.0203
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Brugia malayi	reverse transcriptase	0.002	0.0095	0.0203
Trypanosoma brucei	ingi protein (ORF1)	0.0255	0.2797	0.2728
Echinococcus multilocularis	geminin	0.0138	0.1448	0.1905
Treponema pallidum	ribonuclease H (rnhA)	0.0235	0.2568	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0418	0.4668	0.6257
Echinococcus multilocularis	musashi	0.0022	0.0117	0.0106
Brugia malayi	hypothetical protein	0.0418	0.4668	1
Schistosoma mansoni	survival motor neuron protein	0.0085	0.0845	0.081
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0412	0.0883
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0038	0.0082
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.002	0.0095	0.0122
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0292	0.0549
Brugia malayi	hypothetical protein	0.002	0.0095	0.0203
Schistosoma mansoni	lamin	0.0022	0.0117	0.0079
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0412	0.0883
Schistosoma mansoni	phosphoglucomutase	0.0235	0.2568	0.2539
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0412	0.0883
Schistosoma mansoni	hypothetical protein	0.0033	0.0239	0.0202
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Echinococcus granulosus	survival motor neuron protein 1	0.0418	0.4668	1
Leishmania major	ribonuclease H1, putative	0.0235	0.2568	0.5
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Schistosoma mansoni	intermediate filament proteins	0.0022	0.0117	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0418	0.4668	1
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0255	0.2797	0.2728
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Toxoplasma gondii	ribonuclease HI protein	0.0235	0.2568	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0022	0.0117	0.025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0292	0.0255
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.002	0.0095	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0112	0.0241
Schistosoma mansoni	phosphoglucomutase	0.0235	0.2568	0.2539
Onchocerca volvulus		0.0085	0.0845	0.3033
Brugia malayi	reverse transcriptase	0.002	0.0095	0.0203
Onchocerca volvulus		0.0022	0.0117	0.009
Trypanosoma cruzi	ribonuclease H1, putative	0.0235	0.2568	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Echinococcus granulosus	lamin dm0	0.0022	0.0117	0.017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0292	0.0255
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0412	0.0883
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Brugia malayi	hypothetical protein	0.002	0.0095	0.0203
Brugia malayi	hypothetical protein	0.002	0.0095	0.0203
Echinococcus multilocularis	lamin	0.0022	0.0117	0.0106
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Schistosoma mansoni	lamin	0.0022	0.0117	0.0079
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0659	0.7438	1
Echinococcus granulosus	intermediate filament protein	0.0022	0.0117	0.017
Schistosoma mansoni	protein kinase	0.002	0.0095	0.0057
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Trypanosoma brucei	ribonuclease H1	0.0235	0.2568	0.2497
Brugia malayi	Zinc knuckle family protein	0.002	0.0095	0.0203
Brugia malayi	RNase H family protein	0.0235	0.2568	0.5501
Echinococcus multilocularis	ribonuclease H1	0.0235	0.2568	0.3418
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.002	0.0095	0.0057
Onchocerca volvulus	Ribonuclease H1 homolog	0.0235	0.2568	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Echinococcus multilocularis	RNA directed DNA polymerase	0.002	0.0095	0.0076
Mycobacterium tuberculosis	Possible maturase	0.002	0.0095	0.5
Schistosoma mansoni	hypothetical protein	0.0138	0.1448	0.1415
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0037	0.0292	0.0626
Echinococcus granulosus	RNA directed DNA polymerase	0.002	0.0095	0.0122
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0022	0.0117	0.025
Brugia malayi	RNase H family protein	0.0235	0.2568	0.5501
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0085	0.0845	0.181
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0292	0.0343
Trypanosoma brucei	unspecified product	0.0255	0.2797	0.2728
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0292	0.0549
Loa Loa (eye worm)	intermediate filament protein	0.0022	0.0117	0.025
Onchocerca volvulus		0.0022	0.0117	0.009
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0292	0.0343
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0292	0.0255
Schistosoma mansoni	phosphoglucomutase	0.0235	0.2568	0.2539
Schistosoma mansoni	hypothetical protein	0.0085	0.0845	0.081
Trypanosoma brucei	RNA helicase, putative	0.0881	1	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Brugia malayi	intermediate filament protein	0.0022	0.0117	0.025
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0239	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0038	0.0082
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.002	0.0095	0.0076
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Echinococcus granulosus	KRAB A domain containing protein	0.002	0.0095	0.0122
Echinococcus multilocularis	lamin dm0	0.0022	0.0117	0.0106
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Schistosoma mansoni	hypothetical protein	0.0138	0.1448	0.1415
Giardia lamblia	Ribonuclease H	0.0235	0.2568	1
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0095	0.0057
Echinococcus granulosus	ribonuclease H1	0.0235	0.2568	0.5464
Trypanosoma brucei	ingi protein (ORF1)	0.0255	0.2797	0.2728
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0037	0.0292	0.0626
Schistosoma mansoni	hypothetical protein	0.002	0.0095	0.0057
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0038	0.0082
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.002	0.0095	0.0122
Brugia malayi	Zinc knuckle family protein	0.002	0.0095	0.0203
Trypanosoma cruzi	ribonuclease H1, putative	0.0235	0.2568	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.002	0.0095	0.0076
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0038	0.0082
Brugia malayi	hypothetical protein	0.002	0.0095	0.0203
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Trypanosoma brucei	hypothetical protein, conserved	0.0255	0.2797	0.2728
Brugia malayi	Pao retrotransposon peptidase family protein	0.002	0.0095	0.0203
Schistosoma mansoni	hypothetical protein	0.002	0.0095	0.0057
Brugia malayi	RNase H family protein	0.0235	0.2568	0.5501
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0239	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0117	0.025

Activities

Activity type	Activity value	Assay description	Source	Reference
MPR (functional)	= 0.15	Coronary vasoactivity of the compound was determined as molar potency ratio (MPR), the quotient of ED50 of adenosine by that of the test nucleoside	ChEMBL.	6737436

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 97467

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 304656