Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HI (functional) | = 0 | Hypotensive index (HI) measured as the area under the time-hypotensive response curve for 6-h period at 30mg/kg,po | ChEMBL. | 7401118 |
IVP (functional) | e 0 | Integrated vasodilating potency (the product of compound-induced maximum percent decrease in the perfusion pressure and the duration of the effect in minutes at 100 ug (ia); Coronary vasoconstricting action) | ChEMBL. | 7401118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.