Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HD50 (functional) | = 14.4 uM kg-1 | In vivo anaesthetic activity of the compound after intravenous administration in MF-1 mice was determined by loss of righting reflex using probit analysis | ChEMBL. | 11294393 |
HD50 (functional) | = 14.4 uM kg-1 | In vivo anaesthetic activity of the compound after intravenous administration in MF-1 mice was determined by loss of righting reflex using probit analysis | ChEMBL. | 11294393 |
IC50 (binding) | uM | Inhibition of [35S]-TBPS binding to Gamma-aminobutyric-acid A (GABA-A) receptor of rat whole brain membranes (inactive) | ChEMBL. | 11294393 |
IC50 (binding) | 0 uM | Inhibition of [35S]-TBPS binding to Gamma-aminobutyric-acid A (GABA-A) receptor of rat whole brain membranes (inactive) | ChEMBL. | 11294393 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.