Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0121 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0121 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0075 | 0.2407 | 0.2407 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0107 | 0.7743 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0121 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0121 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0121 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0121 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0121 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0121 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0121 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0121 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0121 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0121 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0121 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0121 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0107 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0121 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.006 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0121 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0121 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.006 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0121 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0121 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0121 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0061 | 0.0151 | 0.0151 |
Chlamydia trachomatis | sulfite reductase | 0.0075 | 0.2407 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0121 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.4 nM | Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue | ChEMBL. | No reference |
IC50 (binding) | = 6.4 nM | Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.