Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Thrombin | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.0111 | 0.0371 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0143 | 0.0679 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0858 | 0.0834 |
Loa Loa (eye worm) | TK protein kinase | 0.1111 | 1 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.1074 | 0.9646 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0125 | 0.0503 | 0.0191 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0535 | 0.4455 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0343 | 0.2597 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0535 | 0.4455 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0107 | 0.0325 | 0.0337 |
Echinococcus multilocularis | neuroglian | 0.0143 | 0.0679 | 0.038 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0535 | 0.4455 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0535 | 0.4455 | 1 |
Echinococcus granulosus | twitchin | 0.0143 | 0.0679 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.0371 | 0.005 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.0371 | 0.0048 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.0371 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Schistosoma mansoni | tyrosine kinase | 0.1074 | 0.9646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0503 | 0.0478 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0157 | 0.0809 | 0.5 |
Schistosoma mansoni | nephrin | 0.0143 | 0.0679 | 0.0704 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.1074 | 0.9646 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0162 | 0.0858 | 0.0572 |
Trypanosoma brucei | thymidine kinase | 0.0535 | 0.4455 | 1 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.1074 | 0.9646 | 1 |
Onchocerca volvulus | 0.0288 | 0.2072 | 0.7645 | |
Giardia lamblia | Thymidine kinase | 0.0535 | 0.4455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.0371 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0431 | 0.3448 | 0.3228 |
Schistosoma mansoni | vesicular amine transporter | 0.0107 | 0.0325 | 0.0337 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.0371 | 0.0346 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0535 | 0.4455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Echinococcus granulosus | roundabout 2 | 0.0162 | 0.0858 | 0.0572 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0107 | 0.0325 | 0.0337 |
Schistosoma mansoni | cell adhesion molecule | 0.0125 | 0.0503 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0325 | 0.0299 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0431 | 0.3448 | 0.3431 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.0809 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0858 | 0.0834 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0535 | 0.4455 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.0371 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.1074 | 0.9646 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0.0371 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.0809 | 0.5 |
Entamoeba histolytica | thymidine kinase, putative | 0.0535 | 0.4455 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.0000025 M | Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin | ChEMBL. | 7452681 |
IC50 (binding) | = 0.0000025 M | Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin | ChEMBL. | 7452681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.