Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0097 | 0.0001 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0097 | 0.0001 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0252 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0141 | 0.071 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0252 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0432 | 0.5301 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Echinococcus granulosus | defective proboscis extension response | 0.0015 | 0.0097 | 0.0001 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0088 | 0.146 | 1 |
Chlamydia trachomatis | chorismate synthase | 0.0179 | 0.3155 | 1 |
Toxoplasma gondii | chorismate synthase, putative | 0.0179 | 0.3155 | 1 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.0088 | 0.146 | 1 |
Plasmodium vivax | chorismate synthase | 0.0179 | 0.3155 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0252 | 0.2549 |
Echinococcus multilocularis | Immunoglobulin | 0.0015 | 0.0097 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0033 | 0.0417 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0661 | 0.8913 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0097 | 0.0021 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0123 | 0.0444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0661 | 0.8913 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.0432 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0337 | 0.6092 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0015 | 0.0097 | 0.0021 |
Echinococcus multilocularis | Immunoglobulin | 0.0015 | 0.0097 | 0.0002 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.0432 | 0.5484 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0661 | 0.922 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0252 | 0.037 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0033 | 0.0417 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0661 | 0.8913 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0661 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0141 | 0.071 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0141 | 0.0134 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0661 | 0.0944 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0015 | 0.0097 | 0.0002 |
Plasmodium falciparum | chorismate synthase | 0.0179 | 0.3155 | 1 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.0432 | 0.0561 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0015 | 0.0097 | 0.0021 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0425 | 0.5192 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0252 | 0.037 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0252 | 0.6035 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0252 | 0.6035 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0709 | 0.9666 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0097 | 0.0001 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0017 | 0.0123 | 0.0429 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.0432 | 0.034 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0709 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0015 | 0.0097 | 0.0001 |
Onchocerca volvulus | 0.0049 | 0.0731 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0252 | 0.0967 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0252 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0141 | 0.071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0252 | 0.2549 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.001 | 0 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0337 | 0.6092 | 0.6054 |
Schistosoma mansoni | nephrin | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0141 | 0.071 |
Mycobacterium ulcerans | chorismate synthase | 0.0179 | 0.3155 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0417 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0252 | 0.2549 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0661 | 0.8913 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0252 | 0.037 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0252 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0252 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0432 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0709 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0033 | 0.0417 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0141 | 0.071 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0709 | 0.9666 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0425 | 0.5371 |
Schistosoma mansoni | rotamase | 0.0033 | 0.0432 | 0.5301 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0252 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0097 | 0.0021 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0252 | 0.037 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.0097 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0425 | 0.5192 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0252 | 0.037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0661 | 0.0572 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0033 | 0.0417 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0252 | 0.6035 |
Schistosoma mansoni | vesicular amine transporter | 0.0015 | 0.0097 | 0.0021 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0661 | 0.0944 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.0097 | 0.0002 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0097 | 0.0021 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0097 | 0.0002 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0252 | 0.037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 60 ng ml-1 | In vitro antimalarial activity against chloroquine-resistant K1 clone of Plasmodium falciparum | ChEMBL. | 15050646 |
IC50 (functional) | = 90 ng ml-1 | In vitro antimalarial activity against chloroquine-sensitive 3D7 clone of Plasmodium falciparum | ChEMBL. | 15050646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.