TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 471.268 | Formula: C18H12Cl2N2O7S
H donors: 0 H acceptors: 6 LogP: 4.75 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C(=O)c1cc2c(n1S(=O)(=O)c1cc(Cl)ccc1[N+](=O)[O-])ccc(c2)Cl
InChi: 1S/C18H12Cl2N2O7S/c1-2-29-18(24)17(23)15-8-10-7-11(19)3-5-13(10)21(15)30(27,28)16-9-12(20)4-6-14(16)22(25)26/h3-9H,2H2,1H3
InChiKey: GNWVASITPSGMSF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	epidermal growth factor receptor	0.0163	0.2717	0.2717
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0039	0.0405	0.0763
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0039	0.0405	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0138	0.3411
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Schistosoma mansoni	tyrosine kinase	0.0163	0.2717	0.5116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0092	0.0173
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0097	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0039	0.0405	0.0405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Brugia malayi	Cation transporter family protein	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0039	0.0404	0.076
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0039	0.0404	0.0404
Schistosoma mansoni	tyrosine kinase	0.016	0.2666	0.5021
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0039	0.0404	0.076
Echinococcus granulosus	glycine receptor subunit beta	0.0039	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0024	0.0138	0.1478
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0018	0.0017	0.0033
Schistosoma mansoni	nAChR subunit	0.0018	0.0017	0.0033
Loa Loa (eye worm)	TK/INSR protein kinase	0.0097	0.1496	0.2818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0033
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0039	0.0405	0.0978
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Echinococcus granulosus	epidermal growth factor receptor	0.0303	0.531	0.531
Loa Loa (eye worm)	LGC-31 protein	0.0039	0.0404	0.076
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Schistosoma mansoni	tyrosine kinase	0.0163	0.2717	0.5116
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Onchocerca volvulus		0.0039	0.0404	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0039	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0022	0.0092	0.0573
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0039	0.0405	0.0978
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Echinococcus granulosus	serine protein kinase ATM	0.0022	0.0092	0.0092
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Trypanosoma cruzi	hypothetical protein, conserved	0.0194	0.3294	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0039	0.0404	0.0404
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0405	0.0763
Schistosoma mansoni	tyrosine kinase	0.0303	0.531	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0039	0.0405	1
Echinococcus granulosus	nAChR subunit	0.0039	0.0404	0.0404
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0022	0.0092	0.0173
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0018	0.0017	0.0017
Echinococcus granulosus	insulin receptor	0.0097	0.1496	0.1496
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0039	0.0405	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0039	0.0405	0.0405
Echinococcus granulosus	glycine receptor subunit beta	0.0039	0.0404	0.0404
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0405	0.0763
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus multilocularis	nAChR subunit	0.0039	0.0404	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0021	0.0073	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0039	0.0405	0.0405
Schistosoma mansoni	tyrosine kinase	0.0097	0.1496	0.2818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	acetylcholine receptor-related	0.0018	0.0017	0.0033
Loa Loa (eye worm)	ACC-1 protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0033
Brugia malayi	Cation transporter family protein	0.0039	0.0404	0.076
Echinococcus granulosus	nAChR subunit	0.0021	0.0073	0.0073
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0039	0.0404	0.076
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0039	0.0405	0.0763
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0039	0.0404	0.076
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0021	0.0073	0.0137
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Schistosoma mansoni	nAChR subunit	0.0018	0.0017	0.0033
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0039	0.0404	0.076
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0018	0.0017	0.0017
Echinococcus multilocularis	epidermal growth factor receptor	0.0303	0.531	0.531
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0039	0.0404	0.0404
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0022	0.0092	0.0173
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0039	0.0405	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0024	0.0138	0.1478
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0405	0.0763
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0033
Onchocerca volvulus		0.0021	0.0073	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0039	0.0404	0.0404
Schistosoma mansoni	tyrosine kinase	0.016	0.2666	0.5021
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0018	0.0017	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Onchocerca volvulus		0.0021	0.0073	0.1438
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0138	0.026
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0018	0.0017	0.0017
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Schistosoma mansoni	neurotransmitter gated ion channel	0.0018	0.0017	0.0033
Echinococcus multilocularis	glycine receptor subunit beta	0.0039	0.0404	0.0404
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0039	0.0404	0.076
Schistosoma mansoni	neurotransmitter gated ion channel	0.0021	0.0073	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0039	0.0404	0.0404
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Onchocerca volvulus		0.0039	0.0404	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Entamoeba histolytica	protein kinase rad3, putative	0.0022	0.0092	0.0573
Onchocerca volvulus		0.0039	0.0404	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0022	0.0092	0.0092
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus multilocularis	epidermal growth factor receptor	0.0163	0.2717	0.2717
Entamoeba histolytica	hypothetical protein	0.0022	0.0092	0.0573
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0039	0.0404	0.076
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0021	0.0073	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0021	0.0073	0.0137
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0021	0.0073	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus multilocularis	serine protein kinase ATM	0.0022	0.0092	0.0092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Trypanosoma cruzi	target of rapamycin kinase 3	0.0039	0.0405	0.0978
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Loa Loa (eye worm)	ACC-1 protein	0.0039	0.0404	0.076
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus multilocularis	nAChR subunit	0.0021	0.0073	0.0073
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0039	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0039	0.0404	0.0404
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0163	0.2717	0.2717
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0018	0.0017	0.0033
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0039	0.0404	0.0404
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	acetylcholine receptor protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Brugia malayi	Cation transporter family protein	0.0039	0.0404	0.076
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0018	0.0017	0.0017
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0039	0.0404	0.0404
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Onchocerca volvulus		0.0039	0.0404	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0039	0.0404	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0138	0.3411
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0092	0.0173
Brugia malayi	Protein kinase domain containing protein	0.0097	0.1496	0.2818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Loa Loa (eye worm)	GABA receptor subunit	0.0021	0.0073	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0092	0.0173
Schistosoma mansoni	tyrosine kinase	0.0097	0.1496	0.2818
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0018	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0405	0.0763
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0039	0.0404	0.0404
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0303	0.531	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0039	0.0404	0.076
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0039	0.0405	0.0405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0039	0.0405	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0404	0.076
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0039	0.0405	0.0978
Brugia malayi	excitatory GABA receptor EXP-1A	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Onchocerca volvulus		0.0039	0.0404	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0033
Onchocerca volvulus		0.0039	0.0404	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0039	0.0404	0.076
Leishmania major	hypothetical protein, conserved	0.0202	0.3432	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0018	0.0017	0.0033
Brugia malayi	Furin-like cysteine rich region family protein	0.0303	0.531	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0039	0.0404	0.076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0555	1	1
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0033
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0039	0.0404	0.0404
Onchocerca volvulus	Putative nachr subunit	0.0039	0.0404	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0021	0.0073	0.0137
Schistosoma mansoni	tyrosine kinase	0.016	0.2666	0.5021
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0039	0.0405	1
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Echinococcus multilocularis		0.0093	0.1421	0.1421
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0039	0.0404	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0405	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0039	0.0404	0.076
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0039	0.0405	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0018	0.0017	0.0033
Schistosoma mansoni	nAChR subunit	0.0039	0.0404	0.076
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0018	0.0017	0.0017
Giardia lamblia	GTOR	0.0039	0.0405	0.5
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0022	0.0092	0.0092
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0039	0.0404	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Echinococcus multilocularis	insulin receptor	0.0097	0.1496	0.1496
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0039	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0017	0.0033
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0039	0.0404	0.076
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0039	0.0404	0.076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0092	0.2269
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0137
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0039	0.0404	0.0404
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0097	0.1496	0.1496

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 31 uM	Protection of infected MT-4 cells from wtIIIB-HIV-1-induced cytopathogenicity	ChEMBL.	15634015
EC50 (functional)	> 31 uM	Protection of infected MT-4 cells from wtIIIB-HIV-1-induced cytopathogenicity	ChEMBL.	15634015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 312669