Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS3 protease/helicase | Starlite/ChEMBL | References |
Homo sapiens | catenin (cadherin-associated protein), beta 1, 88kDa | Starlite/ChEMBL | References |
Homo sapiens | transcription factor 4 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Armadillo/beta-catenin-like repeat family protein | 0.0116 | 0.1901 | 0.1901 |
Schistosoma mansoni | beta-catenin | 0.0116 | 0.1901 | 1 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.018 | 0.9845 | 0.981 | |
Leishmania major | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.01 | 0 | 0.5 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.01 | 0 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | beta catenin | 0.0116 | 0.1901 | 1 |
Loa Loa (eye worm) | HMP-2 protein | 0.0116 | 0.1901 | 0.1901 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.01 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Echinococcus granulosus | beta catenin | 0.0116 | 0.1901 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | Inhibition of human GST tagged Tcf4/beta catenin interaction after 2 hrs using fluorescent AP Attophos substrate by ELISA analysis | ChEMBL. | 26944615 |
IC50 (binding) | = 7 uM | Inhibitory concentration of the compound against hepatitis C virus NS3 protease | ChEMBL. | 15633995 |
IC50 (binding) | = 7 uM | Inhibitory concentration of the compound against hepatitis C virus NS3 protease | ChEMBL. | 15633995 |
IC50 (binding) | < 10 uM | Inhibition of GST-tagged Tcf4 binding to human beta-catenin after 2 hrs by ELISA | ChEMBL. | 23566764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.