Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transcription factor 4 | References | |
Hepatitis C virus | Hepatitis C virus NS3 protease/helicase | Starlite/ChEMBL | References |
Homo sapiens | catenin (cadherin-associated protein), beta 1, 88kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Armadillo/beta-catenin-like repeat family protein | 0.0116 | 0.1901 | 0.1901 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.01 | 0 | 0.5 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | HMP-2 protein | 0.0116 | 0.1901 | 0.1901 |
Echinococcus granulosus | beta catenin | 0.0116 | 0.1901 | 1 |
Leishmania major | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.01 | 0 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Schistosoma mansoni | beta-catenin | 0.0116 | 0.1901 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.018 | 0.9845 | 0.981 | |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.01 | 0 | 0.5 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | beta catenin | 0.0116 | 0.1901 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.01 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | Inhibition of human GST tagged Tcf4/beta catenin interaction after 2 hrs using fluorescent AP Attophos substrate by ELISA analysis | ChEMBL. | 26944615 |
IC50 (binding) | = 7 uM | Inhibitory concentration of the compound against hepatitis C virus NS3 protease | ChEMBL. | 15633995 |
IC50 (binding) | = 7 uM | Inhibitory concentration of the compound against hepatitis C virus NS3 protease | ChEMBL. | 15633995 |
IC50 (binding) | < 10 uM | Inhibition of GST-tagged Tcf4 binding to human beta-catenin after 2 hrs by ELISA | ChEMBL. | 23566764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.