Detailed information for compound 313904

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.29 | Formula: C16H10N6O
  • H donors: 2 H acceptors: 4 LogP: 1.79 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)n1nc(c2c1c1cn[nH]c1cc2)C(=O)N
  • InChi: 1S/C16H10N6O/c17-7-9-1-3-10(4-2-9)22-15-11(14(21-22)16(18)23)5-6-13-12(15)8-19-20-13/h1-6,8H,(H2,18,23)(H,19,20)
  • InChiKey: LNXFGXNXUQLHLF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0231 0.5504 0.5504
Trichomonas vaginalis cyclins, putative 0.005 0.1057 0.144
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0537 0.075
Echinococcus multilocularis cyclin b3 0.005 0.1057 0.1057
Entamoeba histolytica cyclin family protein 0.005 0.1057 0.174
Echinococcus granulosus cyclin y 0.0012 0.012 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.5504 0.8278
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0961 0.1394
Echinococcus multilocularis cyclin G2 0.0012 0.012 0.012
Trichomonas vaginalis cyclin B, putative 0.0121 0.2784 0.4095
Echinococcus multilocularis cyclin dependent kinase 1 0.0231 0.5504 0.5504
Schistosoma mansoni cyclin d 0.0012 0.012 0.012
Giardia lamblia Kinase, CMGC CDK 0.0231 0.5504 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0121 0.2784 0.4167
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.012 0.0117
Loa Loa (eye worm) CYL-1 protein 0.0012 0.012 0.0117
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.005 0.1057 0.1057
Echinococcus granulosus cyclins 0.0012 0.012 0.012
Schistosoma mansoni cyclin l 0.0012 0.012 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Echinococcus granulosus cyclin k 0.0012 0.012 0.012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0231 0.5504 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0012 0.012 0.0117
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0012 0.012 0.012
Loa Loa (eye worm) cyclin domain-containing protein 0.005 0.1057 0.154
Trypanosoma brucei mitotic cyclin 6 0.0121 0.2784 0.4948
Echinococcus granulosus cyclin y 0.0012 0.012 0.012
Echinococcus granulosus cyclin t1 0.0012 0.012 0.012
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.045 0.0612
Giardia lamblia G2/mitotic-specific cyclin B 0.0121 0.2784 0.4948
Trichomonas vaginalis cyclins, putative 0.0082 0.1847 0.2655
Plasmodium falciparum cyclin 0.005 0.1057 0.174
Echinococcus multilocularis G1:S specific cyclin D1 0.0012 0.012 0.012
Schistosoma mansoni cyclin G 0.0012 0.012 0.012
Trypanosoma brucei cdc2-related kinase 3 0.0231 0.5504 1
Brugia malayi glutaminase DH11.1 0.0277 0.6624 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.045 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.005 0.1057 0.144
Entamoeba histolytica cyclin, putative 0.005 0.1057 0.174
Echinococcus granulosus G2:mitotic specific cyclin B3 0.005 0.1057 0.1057
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.045 0.0612
Echinococcus granulosus cyclins 0.005 0.1057 0.1057
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0121 0.2784 0.4948
Trichomonas vaginalis cyclin B, putative 0.0121 0.2784 0.4095
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Echinococcus granulosus cyclin B3 1 0.005 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0121 0.2784 0.4164
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Echinococcus granulosus cyclin 0.0012 0.012 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0961 0.0961
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Echinococcus multilocularis cyclin t1 0.0012 0.012 0.012
Leishmania major cyclin 0.0121 0.2784 0.4948
Schistosoma mansoni g1/s-specific cyclin C 0.0012 0.012 0.012
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0259 0.619 0.619
Echinococcus multilocularis cyclin A3 4 0.0012 0.012 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1338 0.1338
Echinococcus granulosus cyclin b3 0.005 0.1057 0.1057
Echinococcus multilocularis cyclin dependent kinase 5 0.0231 0.5504 0.5504
Brugia malayi Protein kinase domain containing protein 0.0231 0.5504 0.8298
Trypanosoma cruzi cdc2-related kinase 1 0.0231 0.5504 1
Trypanosoma cruzi cdc2-related kinase 3 0.0231 0.5504 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0961 0.0961
Brugia malayi Cyclin, N-terminal domain containing protein 0.0121 0.2784 0.4167
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Trypanosoma cruzi cyclin, putative 0.0121 0.2784 0.4948
Echinococcus multilocularis cyclin k 0.0012 0.012 0.012
Schistosoma mansoni glutaminase 0.0277 0.6624 0.6624
Brugia malayi Cyclin C 0.0012 0.012 0.0121
Echinococcus multilocularis cyclin B 0.0121 0.2784 0.2784
Echinococcus multilocularis cyclin B3 1 0.005 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0026 0.045 0.0617
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.045 0.0612
Echinococcus multilocularis cyclin y 0.0012 0.012 0.012
Entamoeba histolytica cyclin, putative 0.0121 0.2784 0.4948
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0012 0.012 0.012
Trichomonas vaginalis glutaminase, putative 0.0277 0.6624 1
Giardia lamblia Kinase, CMGC CDK 0.0231 0.5504 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0961 0.0961
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0259 0.619 0.619
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0012 0.012 0.012
Echinococcus granulosus cyclin dependent kinase 0.0231 0.5504 0.5504
Schistosoma mansoni Cyclin fold protein 0.0012 0.012 0.012
Schistosoma mansoni cyclin G2 0.0012 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0414 1 1
Brugia malayi hypothetical protein 0.0026 0.045 0.0621
Echinococcus granulosus cpg binding protein 0.0031 0.0578 0.0578
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0012 0.012 0.012
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0578
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Onchocerca volvulus 0.0121 0.2784 1
Giardia lamblia Cyclin A 0.005 0.1057 0.174
Mycobacterium ulcerans glutaminase 0.0277 0.6624 0.5
Loa Loa (eye worm) hypothetical protein 0.0259 0.619 0.934
Loa Loa (eye worm) hypothetical protein 0.0012 0.012 0.0117
Trypanosoma cruzi cdc2-related kinase 3 0.0231 0.5504 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0231 0.5504 1
Brugia malayi hypothetical protein 0.0124 0.2871 0.4299
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0104 0.0104
Toxoplasma gondii hypothetical protein 0.0038 0.0759 0.1186
Echinococcus granulosus cyclin G2 0.0012 0.012 0.012
Echinococcus multilocularis Cyclin L1 0.0012 0.012 0.012
Plasmodium falciparum protein kinase 5 0.0231 0.5504 1
Trichomonas vaginalis cyclins, putative 0.0121 0.2784 0.4095
Brugia malayi hypothetical protein 0.0012 0.012 0.0121
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Echinococcus granulosus cyclins 0.005 0.1057 0.1057
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Echinococcus granulosus cyclins 0.005 0.1057 0.1057
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.5504 0.8278
Loa Loa (eye worm) hypothetical protein 0.0124 0.2871 0.4296
Echinococcus multilocularis cyclin 0.0012 0.012 0.012
Trichomonas vaginalis cyclin D, putative 0.005 0.1057 0.144
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0104 0.0104
Echinococcus granulosus cyclin B 0.0121 0.2784 0.2784
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.045 0.0612
Schistosoma mansoni hypothetical protein 0.0012 0.012 0.012
Entamoeba histolytica cyclin family protein 0.005 0.1057 0.174
Loa Loa (eye worm) cyclin C 0.0012 0.012 0.0117
Brugia malayi hypothetical protein 0.0012 0.012 0.0121
Brugia malayi cell division control protein 2 homolog 0.0231 0.5504 0.8298
Echinococcus multilocularis cpg binding protein 0.0031 0.0578 0.0578
Onchocerca volvulus 0.0029 0.0537 0.1564
Echinococcus multilocularis cyclin dependent kinase 1 0.0231 0.5504 0.5504
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Loa Loa (eye worm) cyclin domain-containing protein 0.0012 0.012 0.0117
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0231 0.5504 0.8298
Echinococcus granulosus cyclins 0.005 0.1057 0.1057
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0259 0.619 0.619
Trypanosoma cruzi cdc2-related kinase 1 0.0231 0.5504 1
Loa Loa (eye worm) glutaminase 0.0277 0.6624 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.045 0.0612
Echinococcus granulosus Cyclin L1 0.0012 0.012 0.012
Trichomonas vaginalis cyclins, putative 0.0121 0.2784 0.4095
Loa Loa (eye worm) hypothetical protein 0.0124 0.2871 0.4296
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1176 0.1961
Trichomonas vaginalis cyclin B, putative 0.0121 0.2784 0.4095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0961 0.0961
Schistosoma mansoni cpg binding protein 0.0029 0.0537 0.0537
Trichomonas vaginalis cyclin B, putative 0.0121 0.2784 0.4095
Schistosoma mansoni cpg binding protein 0.0031 0.0578 0.0578
Trichomonas vaginalis cyclin B3, putative 0.005 0.1057 0.144
Leishmania major hypothetical protein, conserved 0.0026 0.045 0.0612
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Giardia lamblia Hypothetical protein 0.005 0.1057 0.174
Loa Loa (eye worm) glutaminase 2 0.0277 0.6624 1
Schistosoma mansoni cyclin B3 0.005 0.1057 0.1057
Schistosoma mansoni cyclins 0.005 0.1057 0.1057
Echinococcus granulosus cyclins 0.005 0.1057 0.1057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0231 0.5504 0.8278
Schistosoma mansoni cyclin k 0.0012 0.012 0.012
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0231 0.5504 0.8298
Echinococcus granulosus G1:S specific cyclin D1 0.0012 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0011 0.0104 0.0104
Echinococcus multilocularis cyclin dependent kinase 0.0231 0.5504 0.5504
Brugia malayi CXXC zinc finger family protein 0.0029 0.0537 0.0754
Echinococcus multilocularis cyclin G2 0.0012 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0121 0.2784 0.4164
Trypanosoma cruzi CYC2-like cyclin, putative 0.0121 0.2784 0.4948
Loa Loa (eye worm) hypothetical protein 0.0229 0.5443 0.8205
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.045 0.0612
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Schistosoma mansoni hypothetical protein 0.0012 0.012 0.012
Entamoeba histolytica cell division protein kinase 2, putative 0.0231 0.5504 1
Schistosoma mansoni cyclin B 0.0121 0.2784 0.2784
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0231 0.5504 0.8298
Trypanosoma cruzi cyclin 6, putative 0.0121 0.2784 0.4948
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0961 0.0961
Echinococcus granulosus cyclin dependent kinase 1 0.0231 0.5504 0.5504
Trichomonas vaginalis cyclin A, putative 0.0121 0.2784 0.4095
Entamoeba histolytica cell division protein kinase 2, putative 0.0231 0.5504 1
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.5504 0.5504
Echinococcus multilocularis dnaJ subfamily B 0.0414 1 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0012 0.012 0.012
Echinococcus granulosus cyclin dependent kinase 5 0.0231 0.5504 0.5504
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.1057 0.1544
Echinococcus granulosus cyclin A3 4 0.0012 0.012 0.012
Plasmodium vivax protein kinase Crk2 0.0231 0.5504 1
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.5504 0.5504
Loa Loa (eye worm) hypothetical protein 0.007 0.155 0.2288
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Brugia malayi hypothetical protein 0.0016 0.0227 0.0283
Trypanosoma cruzi cyclin, putative 0.0121 0.2784 0.4948
Brugia malayi Cyclin, N-terminal domain containing protein 0.0012 0.012 0.0121
Echinococcus multilocularis cyclin y 0.0012 0.012 0.012
Brugia malayi cyclin fold protein 1 variant b 0.0012 0.012 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0961 0.0961
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0961 0.1397
Trichomonas vaginalis cyclin D, putative 0.005 0.1057 0.144
Echinococcus multilocularis cyclins 0.005 0.1057 0.1057
Trichomonas vaginalis cyclin B, putative 0.005 0.1057 0.144
Echinococcus granulosus cyclin G2 0.0012 0.012 0.012
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0231 0.5504 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0961 0.0961
Trichomonas vaginalis cyclins, putative 0.0121 0.2784 0.4095
Trypanosoma brucei cdc2-related kinase 1 0.0231 0.5504 1
Trichomonas vaginalis cyclins, putative 0.0121 0.2784 0.4095

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.005 uM Inhibition of Cyclin A-cyclin-dependent kinase 2 ChEMBL. 15713378
IC50 (binding) = 0.005 uM Inhibition of Cyclin A-cyclin-dependent kinase 2 ChEMBL. 15713378
IC50 (functional) = 1.94 uM Inhibition of A2780 ovarian tumor cell proliferation ChEMBL. 15713378
IC50 (functional) = 1.94 uM Inhibition of A2780 ovarian tumor cell proliferation ChEMBL. 15713378

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15713378

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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