Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Brugia malayi | valosin containing protein | 0.0777 | 0.564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 0.564 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1325 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0548 | 0.3817 | 0.3817 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0313 | 0.195 | 0.195 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1325 | 1 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1257 | 0.9457 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0548 | 0.3817 | 0.6768 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1325 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0249 | 0.0249 |
Toxoplasma gondii | ATP-citrate lyase, putative | 0.0439 | 0.2949 | 0.2949 |
Giardia lamblia | AAA family ATPase | 0.0793 | 0.5767 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.1257 | 0.9457 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0793 | 0.5767 | 0.5767 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1325 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1257 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1257 | 0.9457 | 0.9457 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1325 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.059 | 0.059 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1257 | 0.9457 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Mycobacterium ulcerans | ATPase | 0.0793 | 0.5767 | 0.5 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0548 | 0.3817 | 0.6768 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0548 | 0.3817 | 0.3817 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1257 | 0.9457 | 1 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0313 | 0.195 | 0.195 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0793 | 0.5767 | 0.5767 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0793 | 0.5767 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Loa Loa (eye worm) | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Schistosoma mansoni | ATP-citrate synthase | 0.0394 | 0.2592 | 0.2592 |
Brugia malayi | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 72 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (functional) | = 72 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (binding) | = 365 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
IC50 (binding) | = 365 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
Ki (binding) | = 5.89 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Ki (binding) | = 5.89 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.