Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0793 | 0.5767 | 0.5 |
Loa Loa (eye worm) | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Schistosoma mansoni | ATP-citrate synthase | 0.0394 | 0.2592 | 0.2592 |
Brugia malayi | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.059 | 0.059 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1257 | 0.9457 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0548 | 0.3817 | 0.6768 |
Mycobacterium ulcerans | ATPase | 0.0793 | 0.5767 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1257 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0548 | 0.3817 | 0.3817 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0793 | 0.5767 | 0.5767 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0313 | 0.195 | 0.195 |
Toxoplasma gondii | ATP-citrate lyase, putative | 0.0439 | 0.2949 | 0.2949 |
Giardia lamblia | AAA family ATPase | 0.0793 | 0.5767 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0793 | 0.5767 | 0.5767 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1257 | 0.9457 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.1257 | 0.9457 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1325 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1257 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1325 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1257 | 0.9457 | 0.9457 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 0.564 | 1 |
Brugia malayi | valosin containing protein | 0.0777 | 0.564 | 1 |
Brugia malayi | ATP-citrate synthase | 0.0439 | 0.2949 | 0.5228 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0548 | 0.3817 | 0.3817 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.059 | 0.059 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1325 | 1 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1325 | 1 | 0.5 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0313 | 0.195 | 0.195 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0777 | 0.564 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1257 | 0.9457 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0548 | 0.3817 | 0.6768 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1325 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0249 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 102 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (functional) | = 102 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (binding) | = 335 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
IC50 (binding) | = 335 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
Ki (binding) | = 9.55 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Ki (binding) | = 9.55 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.