Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hexokinase type IV | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | Hexokinase type IV | 465 aa | 472 aa | 29.2 % |
Candida albicans | N-acetylglucosamine kinase | Hexokinase type IV | 465 aa | 393 aa | 22.6 % |
Onchocerca volvulus | Hexokinase type IV | 465 aa | 453 aa | 40.4 % | |
Candida albicans | N-acetylglucosamine kinase | Hexokinase type IV | 465 aa | 393 aa | 22.6 % |
Onchocerca volvulus | Putative electron transfer flavoprotein subunit alpha, mitochondrial | Hexokinase type IV | 465 aa | 460 aa | 45.0 % |
Onchocerca volvulus | Hexokinase type IV | 465 aa | 456 aa | 45.0 % | |
Onchocerca volvulus | Hexokinase type IV | 465 aa | 458 aa | 42.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.015 | 0.015 |
Schistosoma mansoni | dihydrofolate reductase | 0.2098 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.015 | 0.5 | |
Onchocerca volvulus | 0.0096 | 0.015 | 0.5 | |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.015 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0848 | 0.3847 | 1 |
Onchocerca volvulus | 0.0096 | 0.015 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2098 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2098 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2098 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2098 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0848 | 0.3847 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.015 | 0.015 |
Brugia malayi | Dihydrofolate reductase | 0.2098 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2098 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0848 | 0.3847 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.015 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0848 | 0.3847 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.015 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2098 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0848 | 0.3847 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0848 | 0.3847 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2098 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.015 | 0.015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 5 | Maximal activation of glucokinase at 5 mM glucose | ChEMBL. | 15713416 |
Activity (binding) | = 5 | Maximal activation of glucokinase at 5 mM glucose | ChEMBL. | 15713416 |
EC50 (functional) | = 2.7 uM | Effective concentration for glucokinase activation with 5 mM glucose | ChEMBL. | 15713416 |
EC50 (functional) | = 2.7 uM | Effective concentration for glucokinase activation with 5 mM glucose | ChEMBL. | 15713416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.