Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Starlite/ChEMBL | References |
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Homo sapiens | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | NAD(P)-dependent steroid dehydrogenase protein, putative | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 373 aa | 365 aa | 24.4 % |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Brugia malayi | Synaptic glycoprotein SC2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 254 aa | 208 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0377 | 0.7809 | 1 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0053 | 0 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0377 | 0.7809 | 0.7809 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0377 | 0.7809 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0377 | 0.7809 | 0.7809 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 1 | 1 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0053 | 0 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0377 | 0.7809 | 0.7809 |
Trypanosoma brucei | adenosine kinase, putative | 0.0468 | 1 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0377 | 0.7809 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0468 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0377 | 0.7809 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0468 | 1 | 1 |
Leishmania major | adenosine kinase, putative | 0.0468 | 1 | 1 |
Onchocerca volvulus | 0.0415 | 0.8714 | 1 | |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0377 | 0.7809 | 0.7809 |
Echinococcus granulosus | adenosine kinase | 0.0468 | 1 | 1 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0053 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0468 | 1 | 1 |
Giardia lamblia | Ribokinase | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0377 | 0.7809 | 0.7809 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0468 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0377 | 0.7809 | 0.7809 |
Trypanosoma brucei | adenosine kinase, putative | 0.0468 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0377 | 0.7809 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.7809 | 0.7809 |
Echinococcus multilocularis | adenosine kinase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 0.1 nM | Binding affinity for human 5alpha reductase 2 isozyme | ChEMBL. | 9135028 |
IC50 (binding) | < 0.1 nM | Inhibitory activity measured on human steroid 5-alpha-reductase type 2 | ChEMBL. | 7629802 |
IC50 (binding) | < 0.1 nM | Binding affinity for human 5alpha reductase 2 isozyme | ChEMBL. | 9135028 |
IC50 (binding) | < 0.1 nM | Inhibitory activity measured on human steroid 5-alpha-reductase type 2 | ChEMBL. | 7629802 |
Ki (binding) | = 0.3 nM | Binding affinity for human 5 alpha reductase 1 isozyme | ChEMBL. | 9135028 |
Ki (binding) | = 0.3 nM | Inhibition of recombinant steroid 5-alpha-reductase type I | ChEMBL. | 7629802 |
Ki (binding) | = 0.3 nM | Binding affinity for human 5 alpha reductase 1 isozyme | ChEMBL. | 9135028 |
Ki (binding) | = 0.3 nM | Inhibition of recombinant steroid 5-alpha-reductase type I | ChEMBL. | 7629802 |
Ki (binding) | = 160 nM | Binding affinity for 3-beta-hydroxysteroid dehydrogenase | ChEMBL. | 9135028 |
Ki (binding) | = 160 nM | Inhibition of recombinant human adrenal 3-beta-hydroxy-delta-5-steroid dehydrogenase | ChEMBL. | 7629802 |
Ki (binding) | = 160 nM | Binding affinity for 3-beta-hydroxysteroid dehydrogenase | ChEMBL. | 9135028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.