Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0066 | 0.0048 | 0.0048 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1035 | 0.2421 | 0.928 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0066 | 0.0048 | 0.0115 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.023 | 0.3242 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2112 | 0.5055 | 0.5032 |
Loa Loa (eye worm) | hypothetical protein | 0.4074 | 0.9859 | 0.9858 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.023 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1732 | 0.4125 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0066 | 0.0048 | 0.0183 |
Entamoeba histolytica | ankyrin, putative | 0.008 | 0.0084 | 0.0213 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.5055 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2112 | 0.5055 | 0.5032 |
Schistosoma mansoni | hypothetical protein | 0.2112 | 0.5055 | 0.5032 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2112 | 0.5055 | 0.5032 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0095 | 0.012 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.023 | 0.0194 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1655 | 0.3937 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0095 | 0.012 | 0.0072 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0095 | 0.012 | 0.0072 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4132 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4132 | 1 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1655 | 0.3937 | 0.3937 |
Brugia malayi | hypothetical protein | 0.014 | 0.023 | 0.0183 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1112 | 0.2608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.5055 | 0.5037 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2112 | 0.5055 | 0.5032 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.5055 | 0.5037 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1655 | 0.3937 | 0.9545 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.008 | 0.0084 | 0.0322 |
Brugia malayi | Pre-SET motif family protein | 0.0238 | 0.0469 | 0.0424 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0095 | 0.012 | 0.0072 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0789 | 0.1817 | 0.1778 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2112 | 0.5055 | 0.5032 |
Echinococcus multilocularis | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Echinococcus granulosus | dynactin 5 p25 | 0.008 | 0.0084 | 0.0036 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4132 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0789 | 0.1817 | 0.1778 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4132 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2112 | 0.5055 | 0.5032 |
Echinococcus granulosus | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1655 | 0.3937 | 1 |
Mycobacterium ulcerans | transferase | 0.0077 | 0.0076 | 0.0185 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2112 | 0.5055 | 0.5037 |
Onchocerca volvulus | 0.0271 | 0.055 | 1 | |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2112 | 0.5055 | 0.5032 |
Onchocerca volvulus | 0.0233 | 0.0458 | 0.8072 | |
Entamoeba histolytica | acetyltransferase, putative | 0.008 | 0.0084 | 0.0213 |
Trichomonas vaginalis | set domain proteins, putative | 0.0271 | 0.055 | 0.1169 |
Echinococcus multilocularis | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Leishmania major | carbonic anhydrase-like protein | 0.4132 | 1 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.027 | 0.0547 | 0.1219 |
Echinococcus granulosus | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0238 | 0.0469 | 0.0434 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.027 | 0.0547 | 0.2097 |
Schistosoma mansoni | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Echinococcus granulosus | carbonic anhydrase II | 0.4132 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.2112 | 0.5055 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Onchocerca volvulus | 0.0095 | 0.012 | 0.0916 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4132 | 1 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0233 | 0.0458 | 0.8072 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4132 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4132 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.008 | 0.0084 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2112 | 0.5055 | 0.5032 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.008 | 0.0084 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.023 | 0.3242 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0066 | 0.0048 | 0.0115 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0889 | 0.2064 | 0.7912 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4132 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1732 | 0.4125 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.2112 | 0.5055 | 0.5032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1732 | 0.4125 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4132 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0789 | 0.1817 | 0.1778 |
Schistosoma mansoni | carbonic anhydrase | 0.1655 | 0.3937 | 0.3908 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.012 | 0.0083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Competition (binding) | = 55 % | Displacement of [3H]-MeTRH from Thyrotropin releasing hormone receptor 1 was measured; expressed as % | ChEMBL. | 15664847 |
Competition (binding) | = 55 % | Displacement of [3H]-MeTRH from Thyrotropin releasing hormone receptor 1 was measured; expressed as % | ChEMBL. | 15664847 |
Competition (binding) | = 82 % | Displacement of [3H]-MeTRH from Thyrotropin releasing hormone receptor 1 was measured; expressed as % | ChEMBL. | 15664847 |
Competition (binding) | = 82 % | Displacement of [3H]-MeTRH from Thyrotropin releasing hormone receptor 1 was measured; expressed as % | ChEMBL. | 15664847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.