Detailed information for compound 319426

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.411 | Formula: C15H20N4S
  • H donors: 1 H acceptors: 0 LogP: 3.36 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1s/c(=N\C2CCCCC2)/n(n1)C
  • InChi: 1S/C15H20N4S/c1-19-15(17-13-5-3-2-4-6-13)20-14(18-19)11-7-9-12(16)10-8-11/h7-10,13H,2-6,16H2,1H3/b17-15-
  • InChiKey: GPXKFJSQIAPXSL-ICFOKQHNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 7A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0072 0.0085
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0007 0.0068 0.5
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0007 0.0068 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0072 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0072 0.0085
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0045 0.0884 0.3113
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0014 0.0207 0.0244
Schistosoma mansoni hypothetical protein 0.0015 0.0243 0.0288
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0072 0.0088
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0014 0.0207 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0243 0.059
Echinococcus multilocularis cpg binding protein 0.0029 0.0548 0.0488
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0072 0.0009
Trypanosoma brucei developmentally regulated phosphoprotein 0.0129 0.2688 1
Schistosoma mansoni hypothetical protein 0.0396 0.8456 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0243 0.0182
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0007 0.0068 0.5
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0007 0.0068 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0007 0.0068 0.5
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0007 0.0068 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0243 0.0182
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0207 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0072 0.0013
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0007 0.0068 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0955 0.299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0072 0.0013
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0514 0.1502
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0007 0.0068 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0072 0.0088
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0007 0.0068 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0243 0.059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0072 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0072 0.0013
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0129 0.2688 0.2642
Echinococcus multilocularis muscleblind protein 1 0.0145 0.3033 0.2989
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Echinococcus multilocularis heat shock protein 90 0.0007 0.0068 0.0005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Schistosoma mansoni hypothetical protein 0.0015 0.0243 0.0288
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.01 0.0037
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0007 0.0068 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0955 0.299
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0014 0.0207 0.0145
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.01 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0072 0.0013
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni coup transcription factor 0.0007 0.0072 0.0085
Brugia malayi hypothetical protein 0.0035 0.0665 0.2013
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0207 0.0467
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0014 0.0207 0.0244
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0207 0.0145
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0007 0.0068 0.5
Brugia malayi nuclear hormone receptor 0.0007 0.0072 0.0013
Loa Loa (eye worm) hypothetical protein 0.0145 0.3033 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Schistosoma mansoni heat shock protein 0.0007 0.0068 0.0081
Mycobacterium leprae Probable two component sensor kinase MprB 0.0007 0.0068 0.5
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0007 0.0068 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0072 0.0013
Schistosoma mansoni hypothetical protein 0.0035 0.0665 0.0787
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0072 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Plasmodium vivax phosphodiesterase gamma, putative 0.0014 0.0207 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0072 0.0009
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 0.0528
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0129 0.2688 0.2642
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0072 0.0009
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0072 0.0009
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus multilocularis muscleblind protein 0.0145 0.3033 0.2989
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Brugia malayi Muscleblind-like protein 0.0145 0.3033 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0007 0.0068 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0207 0.0467
Schistosoma mansoni hypothetical protein 0.0015 0.0243 0.0288
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0072 0.0009
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0068 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0207 0.0528
Trichomonas vaginalis heat shock protein, putative 0.0007 0.0068 0.1176
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0072 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0072 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0072 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0072 0.0009
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0207 0.0528
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0007 0.0068 0.5
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0007 0.0068 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0072 0.0009
Mycobacterium leprae Probable two-component sensor kinase 0.0007 0.0068 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0072 0.0013
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus heat shock protein 0.0007 0.0068 0.0005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Trichomonas vaginalis heat shock protein, putative 0.0007 0.0068 0.1176
Plasmodium falciparum phosphodiesterase gamma, putative 0.0014 0.0207 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0045 0.0884 0.3113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus GPCR family 2 0.0015 0.0243 0.0182
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Leishmania major hypothetical protein, conserved 0.0014 0.0207 0.0528
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0072 0.0013
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0207 0.0145
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni hypothetical protein 0.0033 0.0626 0.074
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0072 0.0009
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Giardia lamblia Hypothetical protein 0.0014 0.0207 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0014 0.0207 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0072 0.0009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0014 0.0207 0.0145
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0007 0.0068 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0072 0.0013
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0207 0.0467
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0072 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0045 0.0884 0.3113
Schistosoma mansoni cpg binding protein 0.0029 0.0548 0.0648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0072 0.0013
Trichomonas vaginalis sensor histidine kinase, putative 0.0007 0.0068 0.1176
Brugia malayi CXXC zinc finger family protein 0.0028 0.0514 0.1502
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0207 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0207 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0014 0.0207 0.0145
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0007 0.0068 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0072 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0207 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0072 0.0013
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Brugia malayi ecdysteroid receptor 0.0007 0.0072 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0007 0.0068 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0072 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Schistosoma mansoni endoplasmin 0.0007 0.0068 0.0081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0243 0.059
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0014 0.0207 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0072 0.0013
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0068 0.1176
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.105 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Echinococcus multilocularis heat shock protein 0.0007 0.0068 0.0005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0052 0.1038 0.9878
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0072 0.0013
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0014 0.0207 0.0145
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0068 0.1176
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0007 0.0068 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0072 0.0088
Schistosoma mansoni pyruvate dehydrogenase 0.0122 0.2534 0.2997
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0068 0.1176
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0072 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0207 0.0467
Schistosoma mansoni heat shock protein 0.0007 0.0068 0.0081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0072 0.0013
Schistosoma mansoni DNA topoisomerase II 0.0007 0.0068 0.0081
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0207 0.0467
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0007 0.0068 0.1176
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0955 0.299
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni cpg binding protein 0.0028 0.0514 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0072 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0063 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0072 0.0013
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0068 0.1176
Mycobacterium ulcerans DNA gyrase subunit B 0.0007 0.0068 0.5
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0014 0.0207 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0072 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0072 0.0085
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0007 0.0068 0.5
Brugia malayi nuclear receptor NHR-88 0.0007 0.0072 0.0013
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0072 0.0085
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0068 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0207 0.0528
Loa Loa (eye worm) histone methyltransferase 0.0009 0.01 0.0105
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0007 0.0068 0.1176
Onchocerca volvulus 0.0028 0.0514 1
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Entamoeba histolytica hypothetical protein 0.0035 0.0665 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0207 0.0145
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0665 0.0606
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0014 0.0207 0.0467
Mycobacterium ulcerans putative regultory protein 0.0007 0.0068 0.5
Onchocerca volvulus 0.0007 0.0072 0.0088
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0014 0.0207 0.0467
Leishmania major developmentally regulated phosphoprotein-like protein 0.0129 0.2688 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0243 0.059
Loa Loa (eye worm) hypothetical protein 0.0145 0.3033 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.8456 0.8446
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0072 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0072 0.0085
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0007 0.0068 0.5
Echinococcus multilocularis GPCR, family 2 0.0015 0.0243 0.0182
Entamoeba histolytica hypothetical protein 0.0035 0.0665 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0007 0.0068 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0072 0.0013
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0207 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0007 0.0068 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0129 0.2688 1
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0072 0.0013
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0.0068 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0626 0.188
Entamoeba histolytica hypothetical protein 0.0035 0.0665 1
Giardia lamblia hypothetical protein 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Echinococcus granulosus heat shock protein 90 0.0007 0.0068 0.0005
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0007 0.0068 0.1176
Loa Loa (eye worm) PDE1B protein 0.0014 0.0207 0.0467
Schistosoma mansoni pyruvate dehydrogenase 0.0122 0.2534 0.2997
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Echinococcus granulosus cpg binding protein 0.0029 0.0548 0.0488
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0007 0.0068 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0072 0.0085
Trichomonas vaginalis DNA topoisomerase II, putative 0.0007 0.0068 0.1176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0207 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0468 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0207 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0207 0.0145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0072 0.0009
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0014 0.0207 0.0528
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0007 0.0068 0.0005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Mycobacterium ulcerans two component regulator - sensor kinase 0.0007 0.0068 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Loa Loa (eye worm) hypothetical protein 0.0033 0.0626 0.188
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0207 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0955 0.299
Trichomonas vaginalis endoplasmin, putative 0.0007 0.0068 0.1176
Brugia malayi kinase, mitochondrial precursor 0.0129 0.2688 0.8836
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0072 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0072 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0072 0.0013
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0014 0.0207 0.0145
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0207 0.0467
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Echinococcus granulosus muscleblind protein 0.0145 0.3033 0.2989
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0129 0.2688 0.2642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0072 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0207 0.0244
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.8456 0.8446
Schistosoma mansoni endoplasmin 0.0007 0.0068 0.0081
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Mycobacterium tuberculosis Conserved protein 0.0007 0.0068 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0072 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0243 0.0288
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0014 0.0207 0.0528
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0014 0.0207 0.0244
Schistosoma mansoni pyruvate dehydrogenase 0.0129 0.2688 0.3179
Plasmodium falciparum phosphodiesterase delta, putative 0.0014 0.0207 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1186 0.1403
Leishmania major hypothetical protein, conserved 0.0014 0.0207 0.0528
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0007 0.0068 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0072 0.0085
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0014 0.0207 0.0467
Leishmania major cAMP-specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0207 0.141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0072 0.0085
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0007 0.0068 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.0548 0.0648
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0072 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0097 0.0097
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0207 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0207 0.0528
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0072 0.0085
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0207 1
Entamoeba histolytica hypothetical protein 0.0035 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0072 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0045 0.0884 0.8306
Brugia malayi steroid hormone receptor 0.0007 0.0072 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0243 0.0182
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0207 0.0528
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0207 0.0528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0665 0.0606
Loa Loa (eye worm) hypothetical protein 0.0129 0.2688 0.8836
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0207 0.0528
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0007 0.0068 0.5
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0014 0.0207 0.0528
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0207 0.0528
Mycobacterium tuberculosis Probable two component sensor kinase 0.0007 0.0068 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0665 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0207 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0243 0.0182
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0207 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0007 0.0068 0.5
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0007 0.0068 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.56 uM Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells ChEMBL. 15324874
IC50 (binding) = 0.56 uM Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells ChEMBL. 15324874
IC50 (binding) = 25.75 uM Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324874
IC50 (binding) = 25.75 uM Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells ChEMBL. 15324874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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