Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Bos taurus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Mus musculus | farnesyltransferase, CAAX box, beta | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 1000 nM | Effective concentration against H-ras processing in transformed NIH3T3 cells | ChEMBL. | 15582430 |
EC50 (functional) | > 1000 nM | Effective concentration against H-ras processing in transformed NIH3T3 cells | ChEMBL. | 15582430 |
IC50 (binding) | NT 0 nM | Inhibition of Bovine Geranyl geranyl transeferase | ChEMBL. | 15582430 |
IC50 (binding) | = 47 nM | Inhibition of Bovine farnesyl transeferase | ChEMBL. | 15582430 |
IC50 (binding) | = 47 nM | Inhibition of Bovine farnesyl transeferase | ChEMBL. | 15582430 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.