Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus MW2 | Methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 561 aa | 25.1 % |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 560 aa | 25.2 % |
Brugia malayi | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 665 aa | 22.6 % |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | Methionyl-tRNA synthetase | 657 aa | 699 aa | 26.5 % |
Dictyostelium discoideum | methionine-tRNA ligase | Methionyl-tRNA synthetase | 657 aa | 698 aa | 25.6 % |
Onchocerca volvulus | Methionyl-tRNA synthetase | 657 aa | 662 aa | 23.4 % | |
Treponema pallidum | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 755 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0026 | 0.0865 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0026 | 0.0865 | 0.3301 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0033 | 0.2067 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0033 | 0.2067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0026 | 0.0865 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0022 | 0.0273 | 0.132 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0033 | 0.2067 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0033 | 0.2067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Echinococcus multilocularis | sodium channel protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0033 | 0.2067 | 0.1845 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0033 | 0.2067 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0033 | 0.2067 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0046 | 0.4213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0033 | 0.2067 | 0.1845 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0033 | 0.2067 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0033 | 0.2067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Onchocerca volvulus | 0.0027 | 0.1106 | 1 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0022 | 0.0273 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0273 | 0.132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 29 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
IC50 (binding) | = 29 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Enterococcus faecalis 1 | ChEMBL. | 15225702 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Staphylococcus aureus Oxford | ChEMBL. | 15225702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.