Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | synaptic vesicle 2 protein | 0.0044 | 0.034 | 0.0281 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0344 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | major facilitator superfamily permease | 0.0044 | 0.034 | 0.5 |
Trichomonas vaginalis | myo-inositol transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0344 | 1 | 1 |
Trypanosoma brucei | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transport protein, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Trypanosoma cruzi | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter, lmgt2 | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST2 | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0039 | 0.0169 | 0.0109 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | Putative transporter | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Mycobacterium tuberculosis | Probable conserved integral membrane transport protein | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.6171 | 0.6147 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0061 |
Trypanosoma cruzi | hexose transporter | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0044 | 0.034 | 0.0281 |
Plasmodium vivax | RNA helicase-1, putative | 0.0344 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0344 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter, lmgt1 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0039 | 0.0169 | 0.0109 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0061 |
Trypanosoma brucei | glucose transporter 2A | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0497 | 0.0497 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST3 | 0.0044 | 0.034 | 0.0281 |
Plasmodium vivax | hexose transporter | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0061 | 0.0061 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0061 | 0.5 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Plasmodium vivax | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | sodium channel protein | 0.0039 | 0.0169 | 0.0109 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0344 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0497 | 0.0497 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0344 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | Sugar transporter ERD6 protein | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0061 | 0.5 |
Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter, lmgt3 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0497 | 0.0497 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | major facilitator superfamily protein | 0.0044 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Mycobacterium ulcerans | fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT | 0.0044 | 0.034 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0497 | 0.0497 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium ulcerans | integral membrane transport protein | 0.0044 | 0.034 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0061 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | glucose transporter | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Mycobacterium tuberculosis | Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium ulcerans | sugar-transport integral membrane protein SugI | 0.0044 | 0.034 | 1 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | sugar transporter | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST1 | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Trypanosoma brucei | myo-inositol/proton symporter (MIT) | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0344 | 1 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0039 | 0.0169 | 0.0109 |
Loa Loa (eye worm) | sugar transporter | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0061 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter 1E | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0061 | 0.0061 |
Brugia malayi | major facilitator superfamily protein | 0.0044 | 0.034 | 0.034 |
Mycobacterium ulcerans | sugar transporter | 0.0044 | 0.034 | 1 |
Leishmania major | myo-inositol/proton symporter (MIT) | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 300 uM | Antagonistic activity against HOXA1-PBX1/DNA complex formation by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.