Detailed information for compound 320998

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.175 | Formula: C17H20Br2N4O
  • H donors: 3 H acceptors: 3 LogP: 4.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cc(CNCCCNc2nc(O)c3c(n2)CCC3)cc(c1)Br
  • InChi: 1S/C17H20Br2N4O/c18-12-7-11(8-13(19)9-12)10-20-5-2-6-21-17-22-15-4-1-3-14(15)16(24)23-17/h7-9,20H,1-6,10H2,(H2,21,22,23,24)
  • InChiKey: OIBIQDZGRJHJRN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus subsp. aureus MW2 Methionyl-tRNA synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania braziliensis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Schistosoma mansoni methionine-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Neospora caninum Methionine--tRNA ligase (EC 6.1.1.10), related Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei gambiense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania infantum methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium yoelii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania mexicana methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Echinococcus granulosus methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium vivax methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium leprae Probable methionyl-tRNA synthase MetS Get druggable targets OG5_127468 All targets in OG5_127468
Trichomonas vaginalis methionine-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) tyrosyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Giardia lamblia Methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania major methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium parvum methionyl-tRNA synthetase of possible bacterial origin Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Echinococcus multilocularis methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium berghei methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Onchocerca volvulus Get druggable targets OG5_127468 All targets in OG5_127468
Schistosoma japonicum ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium knowlesi methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma congolense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Babesia bovis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Toxoplasma gondii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium ulcerans methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania donovani methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium falciparum methionine--tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium hominis methionine -- tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma cruzi methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Methionyl-tRNA synthetase   657 aa 662 aa 23.4 %
Dictyostelium discoideum methionine-tRNA ligase Methionyl-tRNA synthetase   657 aa 698 aa 25.6 %
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic Methionyl-tRNA synthetase   657 aa 561 aa 25.1 %
Entamoeba histolytica methionyl-tRNA synthetase, putative Methionyl-tRNA synthetase   657 aa 699 aa 26.5 %
Brugia malayi methionyl-tRNA synthetase Methionyl-tRNA synthetase   657 aa 665 aa 22.6 %
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic Methionyl-tRNA synthetase   657 aa 560 aa 25.2 %
Treponema pallidum methionyl-tRNA synthetase Methionyl-tRNA synthetase   657 aa 755 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Melatonin receptor type 1A 0.0045 0.93 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.93 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.93 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.93 1
Echinococcus multilocularis neuropeptide receptor 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Plasmodium vivax methionine--tRNA ligase, putative 0.0033 0.4906 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus multilocularis somatostatin receptor 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.93 1
Brugia malayi follicle stimulating hormone receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus sex peptide receptor 0.0045 0.93 1
Echinococcus granulosus g protein coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.93 1
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.93 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0033 0.4906 0.5
Schistosoma mansoni opsin-like receptor 0.0045 0.93 1
Schistosoma mansoni biogenic amine receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Schistosoma mansoni neuropeptide receptor 0.0045 0.93 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.93 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.93 1
Schistosoma mansoni neuropeptide receptor 0.0045 0.93 1
Echinococcus multilocularis sex peptide receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi Serotonin receptor 0.0045 0.93 1
Schistosoma mansoni hypothetical protein 0.0045 0.93 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.93 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.93 1
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0033 0.4906 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.93 1
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Echinococcus granulosus g protein coupled receptor 0.0045 0.93 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.93 1
Schistosoma mansoni histamine h1 receptor 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.93 1
Echinococcus granulosus neuropeptide s receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Giardia lamblia Methionyl-tRNA synthetase 0.0033 0.4906 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Schistosoma mansoni adenoreceptor 0.0045 0.93 1
Brugia malayi G protein-coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.93 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.93 1
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.93 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.93 1
Schistosoma mansoni opsin-like receptor 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.93 1
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Schistosoma mansoni hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Leishmania major methionyl-tRNA synthetase, putative 0.0033 0.4906 0.5
Onchocerca volvulus 0.0045 0.93 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.93 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.93 1
Brugia malayi RE15519p 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi methionyl-tRNA synthetase 0.0033 0.4906 0.3936
Schistosoma mansoni hypothetical protein 0.0045 0.93 1
Brugia malayi sulfakinin receptor protein 0.0045 0.93 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.93 1
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0033 0.4906 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.93 1
Echinococcus granulosus allatostatin A receptor 0.0045 0.93 1
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.93 1
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0033 0.4906 0.5275
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Schistosoma mansoni hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.93 1
Schistosoma mansoni amine GPCR 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0045 0.93 1
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.93 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.93 1
Schistosoma mansoni biogenic amine receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.93 1
Echinococcus granulosus g protein coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.93 1
Brugia malayi Serotonin receptor 0.0045 0.93 1
Echinococcus granulosus neuropeptide receptor 0.0045 0.93 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi ORL1-like opioid receptor 0.0045 0.93 1
Loa Loa (eye worm) TYRA-2 protein 0.0045 0.93 1
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Schistosoma mansoni opsin-like receptor 0.0045 0.93 1
Echinococcus granulosus orexin receptor type 2 0.0045 0.93 1
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0033 0.4906 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.93 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.93 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.93 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.93 1
Echinococcus multilocularis fmrfamide receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.93 1
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0033 0.4906 0.5
Schistosoma mansoni amine GPCR 0.0045 0.93 1
Brugia malayi G-protein coupled receptor 0.0045 0.93 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.93 1
Schistosoma mansoni amine GPCR 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Brugia malayi AKH receptor 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0026 0.2054 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.93 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.93 1
Echinococcus granulosus neuropeptide receptor 0.0045 0.93 1
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Echinococcus granulosus somatostatin receptor 0.0045 0.93 1
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.93 1
Echinococcus multilocularis allatostatin A receptor 0.0045 0.93 1
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.93 1
Brugia malayi neuropeptide F receptor 0.0045 0.93 1
Brugia malayi G-protein coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Brugia malayi neuropeptide F receptor 0.0045 0.93 1
Schistosoma mansoni biogenic amine receptor 0.0045 0.93 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.93 1
Plasmodium falciparum methionine--tRNA ligase 0.0033 0.4906 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis fmrfamide receptor 0.0045 0.93 1
Brugia malayi Dopamine receptor 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Schistosoma mansoni neuropeptide receptor 0.0045 0.93 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0045 0.93 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.93 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.93 1
Brugia malayi larval opioid receptor 0.0045 0.93 1
Echinococcus multilocularis serotonin receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Brugia malayi Dopamine receptor protein 1 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Schistosoma mansoni amine GPCR 0.0045 0.93 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0033 0.4906 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.93 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.93 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.93 1
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.93 1
Echinococcus multilocularis serotonin receptor 0.0045 0.93 1
Brugia malayi putative neuropeptide receptor 0.0045 0.93 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.93 1
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.93 1
Echinococcus multilocularis g protein coupled receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus multilocularis neuropeptide receptor 0.0045 0.93 1
Brugia malayi Dopamine receptor protein 2 0.0045 0.93 1
Echinococcus granulosus g-protein coupled receptor 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.93 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.93 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.93 1
Brugia malayi GnHR receptor homolog 0.0045 0.93 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.93 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.93 1
Brugia malayi hypothetical protein 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis g protein coupled receptor 0.0045 0.93 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.93 1
Echinococcus granulosus serotonin receptor 0.0045 0.93 1
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus granulosus hypothetical protein 0.0045 0.93 1
Schistosoma mansoni amine GPCR 0.0045 0.93 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0045 0.93 1
Treponema pallidum methionyl-tRNA synthetase 0.0026 0.2054 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.93 1
Schistosoma mansoni myosin xvIII 0.0045 0.93 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0033 0.4906 0.5
Onchocerca volvulus 0.0045 0.93 1
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.93 1
Schistosoma mansoni neuropeptide receptor 0.0045 0.93 1
Echinococcus multilocularis g protein coupled receptor 0.0045 0.93 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.93 1
Echinococcus multilocularis orexin receptor type 2 0.0045 0.93 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.93 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.93 1
Echinococcus granulosus fmrfamide receptor 0.0045 0.93 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.93 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.93 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.93 1
Onchocerca volvulus 0.0045 0.93 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.93 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 580 nM Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase ChEMBL. 15225702
IC50 (binding) = 580 nM Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase ChEMBL. 15225702
MIC (functional) > 64 ug ml-1 Antibacterial activity against Staphylococcus aureus Oxford ChEMBL. 15225702
MIC (functional) > 64 ug ml-1 Antibacterial activity against Enterococcus faecalis 1 ChEMBL. 15225702

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.