Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Leishmania major | glucose transporter, lmgt1 | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0344 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0061 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | hexose transporter | 0.0044 | 0.034 | 0.0281 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0344 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0344 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.6171 | 0.6147 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0039 | 0.0169 | 0.0109 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0344 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0497 | 0.0497 |
Plasmodium vivax | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST3 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Plasmodium vivax | hexose transporter | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0061 | 0.0061 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0061 | 0.5 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0039 | 0.0169 | 0.0109 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter 2A | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0497 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter, lmgt2 | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST2 | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0344 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transport protein, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Wolbachia endosymbiont of Brugia malayi | major facilitator superfamily permease | 0.0044 | 0.034 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0344 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | synaptic vesicle 2 protein | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | myo-inositol transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0039 | 0.0169 | 0.0109 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | Putative transporter | 0.0044 | 0.034 | 0.0281 |
Mycobacterium tuberculosis | Probable conserved integral membrane transport protein | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Sugar transporter family protein | 0.0044 | 0.034 | 0.034 |
Mycobacterium ulcerans | sugar-transport integral membrane protein SugI | 0.0044 | 0.034 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Toxoplasma gondii | sugar transporter ST1 | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0061 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | glucose transporter | 0.0044 | 0.034 | 0.034 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Mycobacterium tuberculosis | Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Leishmania major | myo-inositol/proton symporter (MIT) | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter 1E | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0061 | 0.0061 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium ulcerans | sugar transporter | 0.0044 | 0.034 | 1 |
Brugia malayi | major facilitator superfamily protein | 0.0044 | 0.034 | 0.034 |
Trypanosoma brucei | myo-inositol/proton symporter (MIT) | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | sugar transporter | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | sodium channel protein | 0.0039 | 0.0169 | 0.0109 |
Loa Loa (eye worm) | sugar transporter | 0.0044 | 0.034 | 0.034 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0344 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0344 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0344 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0061 | 0.5 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0044 | 0.034 | 0.0281 |
Leishmania major | glucose transporter, lmgt3 | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0497 | 0.0497 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | major facilitator superfamily protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium ulcerans | fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT | 0.0044 | 0.034 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Echinococcus multilocularis | Sugar transporter ERD6 protein | 0.0044 | 0.034 | 0.0281 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0344 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0044 | 0.034 | 0.034 |
Trypanosoma cruzi | hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Brugia malayi | Major Facilitator Superfamily protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | solute carrier family 22 | 0.0044 | 0.034 | 0.0281 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Trypanosoma brucei | glucose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Mycobacterium ulcerans | integral membrane transport protein | 0.0044 | 0.034 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.034 | 0.0281 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0044 | 0.034 | 0.0281 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0044 | 0.034 | 0.0281 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0497 | 0.0497 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0044 | 0.034 | 0.034 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Trichomonas vaginalis | sugar transporter, putative | 0.0044 | 0.034 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 272 uM | Antagonistic activity against HOXA1-PBX1/DNA complex formation by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.