Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.1834 | 0.1834 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.036 | 0.036 |
Schistosoma mansoni | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.1834 | 0.1834 |
Treponema pallidum | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.1834 | 0.1834 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0108 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0773 | 0.0773 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.1834 | 0.1834 |
Onchocerca volvulus | 0.089 | 0.8144 | 0.5 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.1834 | 0.1834 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Brugia malayi | hypothetical protein | 0.0391 | 0.348 | 0.348 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0773 | 0.0773 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Echinococcus multilocularis | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.089 | 0.8144 | 0.6022 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0773 | 0.0773 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0773 | 0.0773 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.1089 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1834 | 0.1834 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0773 | 0.0773 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.036 | 0.036 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0193 | 0.0193 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.1089 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase cytosolic family member | 0.1089 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0773 | 0.0773 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0773 | 0.0773 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.1834 | 0.1834 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.0773 | 1 |
Mycobacterium leprae | PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE | 0.1089 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1834 | 1 |
Mycobacterium tuberculosis | Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase | 0.1089 | 1 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.0773 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.1089 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.1834 | 1 |
Mycobacterium ulcerans | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0773 | 0.0773 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.089 | 0.8144 | 0.6022 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0773 | 0.0773 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1834 | 0.1834 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1135 | 0.1135 |
Brugia malayi | phosphoenolpyruvate carboxykinase [GTP] | 0.1089 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.1834 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0773 | 0.0773 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0011 | 0.0011 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.036 | 0.036 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1135 | 0.1135 |
Chlamydia trachomatis | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1135 | 0.1135 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0773 | 0.0773 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1834 | 1 |
Giardia lamblia | Phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 0.5 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.1089 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0773 | 0.0773 |
Echinococcus granulosus | phosphoenolpyruvate carboxykinase | 0.1089 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.036 | 0.036 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.1089 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.1089 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.6 nM | Binding affinity towards human cloned carbonic anhydrase I | ChEMBL. | 15501039 |
Ki (binding) | = 0.6 nM | Binding affinity towards human cloned carbonic anhydrase II | ChEMBL. | 15501039 |
Ki (binding) | = 0.6 nM | Binding affinity towards human cloned carbonic anhydrase I | ChEMBL. | 15501039 |
Ki (binding) | = 0.6 nM | Binding affinity towards human cloned carbonic anhydrase II | ChEMBL. | 15501039 |
Ki (binding) | = 18 nM | Binding affinity towards human cloned carbonic anhydrase IX | ChEMBL. | 15501039 |
Ki (binding) | = 18 nM | Binding affinity towards human cloned carbonic anhydrase IX | ChEMBL. | 15501039 |
Selectivity (binding) | = 0.03 | Binding affinity ratio towards human cloned carbonic anhydrase II to that of human cloned carbonic anhydrase IX | ChEMBL. | 15501039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.