Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.307 | 0.5 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0052 | 0.5988 | 1 |
Brugia malayi | intracellular kinase | 0.0052 | 0.5988 | 0.8881 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0052 | 0.5988 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.3808 | 0.6361 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0052 | 0.5988 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 0.1135 | 0.1683 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.5988 | 0.352 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.5988 | 0.352 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.3808 | 0.5649 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.3808 | 0.3016 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.1135 | 0.1683 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0073 | 0.9853 | 0.9835 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0052 | 0.5988 | 0.5474 |
Entamoeba histolytica | protein kinase, putative | 0.0052 | 0.5988 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.3808 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0052 | 0.5988 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0052 | 0.5988 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0052 | 0.5988 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.6742 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0052 | 0.5988 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.3808 | 0.6361 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0052 | 0.5988 | 0.8881 |
Echinococcus granulosus | protein kinase shaggy | 0.0052 | 0.5988 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0074 | 1 | 1 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0074 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0074 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.6742 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.3808 | 0.5649 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0074 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.3808 | 0.6361 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0052 | 0.5988 | 0.8881 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.3808 | 0.6361 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.5988 | 0.5474 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0052 | 0.5988 | 0.5474 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.307 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0052 | 0.5988 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.3808 | 0.3016 |
Trichomonas vaginalis | STE family protein kinase | 0.0074 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.3808 | 0.3016 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.3808 | 0.3016 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0074 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.1135 | 0.1683 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.3808 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0052 | 0.5988 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.1135 | 0.1683 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.1135 | 0.1683 |
Onchocerca volvulus | 0.0052 | 0.5988 | 1 | |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0052 | 0.5988 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.9 nM | Agonist activity as alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 | ChEMBL. | 15380208 |
EC50 (functional) | = 0.9 nM | Agonist activity as alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 | ChEMBL. | 15380208 |
Efficacy (functional) | = 66 % | Agonist activity as efficacy in alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 | ChEMBL. | 15380208 |
Efficacy (functional) | = 66 % | Agonist activity as efficacy in alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 | ChEMBL. | 15380208 |
Efficacy (functional) | = 80 % | Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation | ChEMBL. | 15380208 |
Efficacy (functional) | = 80 % | Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation | ChEMBL. | 15380208 |
Efficacy (functional) | = 84 % | Inhibition of 1 nM 17-beta- estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells | ChEMBL. | 15380208 |
Efficacy (functional) | = 84 % | Inhibition of 1 nM 17-beta- estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells | ChEMBL. | 15380208 |
IC50 (functional) | = 0.9 nM | Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation | ChEMBL. | 15380208 |
IC50 (functional) | = 0.9 nM | Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation | ChEMBL. | 15380208 |
IC50 (functional) | = 53 nM | Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells | ChEMBL. | 15380208 |
IC50 (functional) | = 53 nM | Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells | ChEMBL. | 15380208 |
Ki (binding) | = 0.5 nM | Inhibition of [3H]-estradiol binding to Estrogen receptor alpha | ChEMBL. | 15380208 |
Ki (binding) | = 0.9 nM | Inhibition of [3H]-estradiol binding to Estrogen receptor beta | ChEMBL. | 15380208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.