Detailed information for compound 32321

Basic information

Technical information
  • TDR Targets ID: 32321
  • Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindo l-3-yl]-N-[(2S)-1-hydroxypropan-2-yl]acetamid e
  • MW: 414.882 | Formula: C22H23ClN2O4
  • H donors: 2 H acceptors: 3 LogP: 3.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](NC(=O)Cc1c(C)n(c2c1cc(OC)cc2)C(=O)c1ccc(cc1)Cl)C
  • InChi: 1S/C22H23ClN2O4/c1-13(12-26)24-21(27)11-18-14(2)25(20-9-8-17(29-3)10-19(18)20)22(28)15-4-6-16(23)7-5-15/h4-10,13,26H,11-12H2,1-3H3,(H,24,27)/t13-/m0/s1
  • InChiKey: VDUMTSIKQQNNNR-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-[(1S)-2-hydroxy-1-methyl-ethyl]acetamide
  • 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]-N-[(1S)-2-hydroxy-1-methylethyl]acetamide
  • 2-[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]-N-[(2S)-1-hydroxypropan-2-yl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Ovis aries Cyclooxygenase-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Schistosoma mansoni tyrosine kinase 0.0494 0.9114 1
Schistosoma mansoni tyrosine kinase 0.0101 0.0954 0.0812
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis serotonin receptor 0.0088 0.0683 0.0461
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.0327 0.0106
Echinococcus granulosus FTZ F1 alpha 0.0071 0.0327 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.0327 0.0096
Echinococcus multilocularis neuropeptide FF receptor 2 0.0088 0.0683 0.0461
Echinococcus multilocularis somatostatin receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis G protein coupled receptor 139 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0504 0.4977
Schistosoma mansoni adapter molecule crk 0.0108 0.1095 0.097
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.0327 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0683 0.0461
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Echinococcus granulosus fmrfamide receptor 0.0088 0.0683 0.0461
Brugia malayi Melatonin receptor type 1A 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Abl 0.0302 0.513 0.5014
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis serotonin receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0683 0.0461
Echinococcus granulosus hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus serotonin receptor 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0327 0.0106
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0683 0.0461
Onchocerca volvulus Peroxidase homolog 0.0079 0.0504 0.4977
Echinococcus granulosus dual specificity mitogen activated protein 0.0079 0.0505 0.0279
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0079 0.0505 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Echinococcus multilocularis tyrosine protein kinase HCK 0.0386 0.6876 0.6801
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0683 0.0461
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0504 0.0305
Schistosoma mansoni neuropeptide receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.0327 0.0096
Brugia malayi Protein kinase domain containing protein 0.0071 0.0327 0.0105
Schistosoma mansoni hypothetical protein 0.0088 0.0683 0.0507
Echinococcus granulosus tyrosine protein kinase Srms 0.0071 0.0327 0.0096
Echinococcus granulosus tyrosine kinase 0.0071 0.0327 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni growth hormone secretagogue receptor 0.0088 0.0683 0.0507
Schistosoma mansoni growth factor receptor-bound protein 0.0108 0.1095 0.097
Entamoeba histolytica Ras family GTPase 0.0296 0.4995 0.7264
Onchocerca volvulus 0.0088 0.0683 1
Schistosoma mansoni tyrosine kinase 0.0124 0.1431 0.135
Brugia malayi SH2 domain containing protein 0.0071 0.0327 0.0105
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0088 0.0683 0.0461
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0327 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi Blistered cuticle protein 3 0.0079 0.0504 0.0305
Echinococcus granulosus c src tyrosine kinase 0.0124 0.1431 0.1227
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0683 0.0461
Echinococcus granulosus neuropeptide receptor A26 0.0088 0.0683 0.0461
Loa Loa (eye worm) TYRA-2 protein 0.0088 0.0683 0.0461
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0088 0.0683 0.0507
Schistosoma mansoni adenoreceptor 0.0088 0.0683 0.0507
Schistosoma mansoni opsin-like receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis neuropeptide s receptor 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.0327 0.0106
Schistosoma mansoni tyrosine kinase 0.0085 0.0617 0.0433
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0683 0.0461
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.0327 0.0106
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0088 0.0683 0.0507
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0327 0.0106
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0088 0.0683 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Schistosoma mansoni opsin-like receptor 0.0088 0.0683 0.0507
Brugia malayi RE15519p 0.0088 0.0683 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Schistosoma mansoni biogenic amine receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0088 0.0683 0.0461
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.0954 0.0738
Echinococcus multilocularis ras gtpase 0.0296 0.4995 0.4876
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0298 0.0074
Schistosoma mansoni histamine h1 receptor 0.0088 0.0683 0.0507
Echinococcus granulosus neuropeptide receptor 0.0088 0.0683 0.0461
Brugia malayi GnHR receptor homolog 0.0088 0.0683 0.0507
Loa Loa (eye worm) TK protein kinase 0.0441 0.8009 0.7961
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0504 0.0278
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0088 0.0683 0.0461
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi ecdysteroid receptor 0.0071 0.0327 0.0106
Onchocerca volvulus 0.0088 0.0683 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0108 0.1095 0.0882
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0537 1 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Echinococcus granulosus ras gtpase 0.0296 0.4995 0.4876
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.0327 0.0096
Brugia malayi Ras protein let-60 0.0296 0.4995 0.5362
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0079 0.0505 0.0306
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.0327 0.0106
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0088 0.0683 0.0507
Schistosoma mansoni tyrosine kinase 0.0482 0.8867 0.9722
Onchocerca volvulus 0.0088 0.0683 1
Echinococcus multilocularis g-protein coupled receptor 0.0088 0.0683 0.0461
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0088 0.0683 0.0507
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0088 0.0683 0.0461
Schistosoma mansoni neuropeptide receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus 7tm_1 domain containing protein 0.0088 0.0683 0.0461
Schistosoma mansoni protein kinase 0.0079 0.0505 0.0306
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0088 0.0683 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Schistosoma mansoni amine GPCR 0.0088 0.0683 0.0507
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Onchocerca volvulus 0.0088 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.0954 0.0738
Echinococcus granulosus g protein coupled receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni tyrosine kinase 0.0124 0.1431 0.135
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.0327 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0327 0.0106
Echinococcus granulosus neuropeptide s receptor 0.0088 0.0683 0.0461
Brugia malayi Ras-related protein R-Ras2 0.0296 0.4995 0.5362
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0441 0.8009 0.7961
Loa Loa (eye worm) SRC-1 0.0494 0.9114 0.9093
Brugia malayi hypothetical protein 0.0071 0.0327 0.0105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.0327 0.0096
Giardia lamblia Kinase, STE STE20 0.0079 0.0505 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0683 0.0461
Onchocerca volvulus Peroxidase homolog 0.0079 0.0504 0.4977
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.0327 0.0106
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0124 0.1431 0.135
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0327 0.0106
Echinococcus multilocularis orexin receptor type 2 0.0088 0.0683 0.0461
Brugia malayi Protein kinase domain containing protein 0.0071 0.0327 0.0105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.0327 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0327 0.0106
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0683 0.0461
Trichomonas vaginalis rap1 and, putative 0.0296 0.4995 1
Entamoeba histolytica protein kinase, putative 0.0386 0.6876 1
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0504 0.0278
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0088 0.0683 0.0507
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0504 0.4977
Brugia malayi larval opioid receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0425 0.7672 0.7617
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus tyrosine protein kinase Lyn 0.0495 0.9124 0.9103
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0504 0.0278
Onchocerca volvulus 0.0079 0.0504 0.4977
Brugia malayi putative neuropeptide receptor 0.0088 0.0683 0.0507
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0088 0.0683 0.0507
Schistosoma mansoni tyrosine kinase 0.0175 0.2486 0.2537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus granulosus tyrosine protein kinase Src42A 0.0494 0.9114 0.9093
Loa Loa (eye worm) melatonin receptor type 1A 0.0088 0.0683 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0194 0.2892 0.2723
Brugia malayi steroid hormone receptor 0.0071 0.0327 0.0106
Trichomonas vaginalis ral, putative 0.0296 0.4995 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Onchocerca volvulus 0.0088 0.0683 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.0327 0.0096
Brugia malayi SRC-1 0.0494 0.9114 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Echinococcus granulosus g-protein coupled receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0296 0.4995 0.4876
Schistosoma mansoni amine GPCR 0.0088 0.0683 0.0507
Onchocerca volvulus 0.0088 0.0683 1
Onchocerca volvulus 0.0088 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.0327 0.0015
Brugia malayi Furin-like cysteine rich region family protein 0.0175 0.2486 0.2537
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0088 0.0683 0.0461
Brugia malayi putative neuropeptide receptor NPR1 0.0088 0.0683 0.0507
Echinococcus multilocularis dual specificity mitogen activated protein 0.0079 0.0505 0.0279
Echinococcus granulosus dro:myosuppressin receptor 0.0088 0.0683 0.0461
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.0327 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Brugia malayi Serotonin receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0071 0.0327 0.0096
Echinococcus granulosus growth factor receptor bound protein 2 0.0108 0.1095 0.0882
Brugia malayi neuropeptide F receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.0327 0.0106
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0071 0.0327 0.0096
Echinococcus multilocularis allatostatin A receptor 0.0088 0.0683 0.0461
Schistosoma mansoni nck2/grb4 0.0108 0.1095 0.097
Loa Loa (eye worm) TK/ABL protein kinase 0.0537 1 1
Onchocerca volvulus 0.0079 0.0504 0.4977
Entamoeba histolytica ras-1, putative 0.0296 0.4995 0.7264
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Schistosoma mansoni tyrosine kinase 0.0085 0.0617 0.0433
Brugia malayi Protein kinase domain containing protein 0.0071 0.0327 0.0105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.0327 0.0096
Brugia malayi Serotonin receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi G protein-coupled receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase shark 0.0071 0.0327 0.0096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0494 0.9114 0.9093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Schistosoma mansoni hypothetical protein 0.0088 0.0683 0.0507
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0683 0.0461
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0504 0.0305
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0504 0.0278
Trichomonas vaginalis GTP-binding protein rit, putative 0.0296 0.4995 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0683 0.0461
Trichomonas vaginalis rheb, putative 0.0296 0.4995 1
Onchocerca volvulus 0.0088 0.0683 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0441 0.8009 0.7961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.0327 0.0096
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0683 0.0507
Schistosoma mansoni amine GPCR 0.0088 0.0683 0.0507
Loa Loa (eye worm) Ras protein let-60 0.0296 0.4995 0.4876
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0071 0.0327 0.0475
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0079 0.0505 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.0327 0.0096
Echinococcus multilocularis G-protein coupled receptor, putative 0.0088 0.0683 0.0461
Schistosoma mansoni neuropeptide receptor 0.0088 0.0683 0.0507
Echinococcus granulosus 7TM GPCR rhodopsin 0.0088 0.0683 0.0461
Brugia malayi sulfakinin receptor protein 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0683 0.0461
Echinococcus granulosus peroxidasin 0.0079 0.0504 0.0278
Echinococcus granulosus neuropeptide receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis c src tyrosine kinase 0.0124 0.1431 0.1227
Schistosoma mansoni tyrosine kinase 0.0071 0.0327 0.0105
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0088 0.0683 0.0461
Schistosoma mansoni tyrosine kinase 0.0101 0.0954 0.0812
Echinococcus granulosus G protein coupled receptor 139 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.0327 0.0106
Loa Loa (eye worm) hypothetical protein 0.0108 0.1095 0.0882
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0327 0.0096
Echinococcus multilocularis dro:myosuppressin receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0494 0.9114 0.9093
Brugia malayi Protein kinase domain containing protein 0.0071 0.0327 0.0105
Schistosoma mansoni opsin-like receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi G-protein coupled receptor 0.0088 0.0683 0.0507
Brugia malayi protein-tyrosine kinase 0.0441 0.8009 0.8756
Brugia malayi G-protein coupled receptor 0.0088 0.0683 0.0507
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0683 0.0507
Brugia malayi follicle stimulating hormone receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Srms 0.0441 0.8009 0.7961
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0108 0.1095 0.097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.0327 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0327 0.0096
Onchocerca volvulus 0.0088 0.0683 1
Onchocerca volvulus 0.0088 0.0683 1
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0124 0.1431 0.1227
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0494 0.9114 0.9093
Loa Loa (eye worm) TK/EGFR protein kinase 0.0175 0.2486 0.2307
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.0327 0.0106
Schistosoma mansoni peroxidasin 0.0079 0.0504 0.0305
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0079 0.0505 0.0279
Onchocerca volvulus 0.0088 0.0683 1
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0683 0.0461
Echinococcus granulosus tyrosine protein kinase Blk 0.0441 0.8009 0.7961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi ORL1-like opioid receptor 0.0088 0.0683 0.0507
Echinococcus granulosus tyrosine protein kinase Src64B 0.0494 0.9114 0.9093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus multilocularis sex peptide receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.0327 0.0096
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0124 0.1431 0.1227
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0683 0.0461
Onchocerca volvulus 0.0079 0.0504 0.4977
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0683 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Brugia malayi hypothetical protein 0.0079 0.0504 0.0305
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis neuropeptide receptor 0.0088 0.0683 0.0461
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0683 0.0507
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0683 0.0507
Brugia malayi Tyrosine-protein kinase abl-1 0.0302 0.513 0.5514
Echinococcus granulosus somatostatin receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Schistosoma mansoni tyrosine kinase 0.0494 0.9114 1
Schistosoma mansoni tyrosine kinase 0.0085 0.0617 0.0433
Onchocerca volvulus 0.0088 0.0683 1
Echinococcus granulosus g protein coupled receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0088 0.0683 0.0461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0327 0.0106
Echinococcus multilocularis tyrosine kinase 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0494 0.9114 0.9093
Schistosoma mansoni coup transcription factor 0.0071 0.0327 0.0106
Brugia malayi Protein kinase domain containing protein 0.0071 0.0327 0.0105
Brugia malayi Tachykinin-like peptides receptor 99D 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0494 0.9114 0.9093
Onchocerca volvulus Neuropeptide F receptor homolog 0.0088 0.0683 1
Brugia malayi Peroxidasin 0.0079 0.0504 0.0305
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0504 0.4977
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.0327 0.0096
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.0327 0.0096
Echinococcus granulosus tyrosine protein kinase Src42A 0.0425 0.7672 0.7617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.0327 0.0106
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0088 0.0683 1
Brugia malayi nuclear receptor NHR-88 0.0071 0.0327 0.0106
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus allatostatin A receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis peroxidasin 0.0079 0.0504 0.0278
Echinococcus granulosus epidermal growth factor receptor 0.0175 0.2486 0.2307
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.0327 0.0106
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0504 0.0305
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.0327 0.0106
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis epidermal growth factor receptor 0.0175 0.2486 0.2307
Echinococcus multilocularis neuropeptide receptor A26 0.0088 0.0683 0.0461
Onchocerca volvulus 0.0088 0.0683 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0288 0.4832 0.5178
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.0327 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.0327 0.0106
Onchocerca volvulus 0.0088 0.0683 1
Brugia malayi SH2 domain containing protein 0.0071 0.0327 0.0105
Echinococcus granulosus g protein coupled receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0683 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.0327 0.0096
Echinococcus granulosus tyrosine kinase 0.0441 0.8009 0.7961
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Schistosoma mansoni amine GPCR 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0071 0.0327 0.0096
Echinococcus granulosus neuropeptide FF receptor 2 0.0088 0.0683 0.0461
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0079 0.0505 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.0327 0.0106
Schistosoma mansoni peroxidasin 0.0079 0.0504 0.0305
Schistosoma mansoni myosin xvIII 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Blk 0.0441 0.8009 0.7961
Brugia malayi nuclear hormone receptor 0.0071 0.0327 0.0106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.0327 0.0106
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0088 0.0683 0.0507
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.0327 0.0096
Echinococcus granulosus tachykinin peptides receptor 99D 0.0088 0.0683 0.0461
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0088 0.0683 0.0461
Brugia malayi Variant SH3 domain containing protein 0.0108 0.1095 0.097
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.0327 0.0106
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0494 0.9114 0.9093
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0683 0.0507
Onchocerca volvulus 0.0071 0.0327 0.0015
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus peptide allatostatin:somatostatin 0.0088 0.0683 0.0461
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0494 0.9114 0.9093
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Brugia malayi Dopamine receptor 0.0088 0.0683 0.0507
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0683 0.0461
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0683 0.0461
Brugia malayi Dopamine receptor protein 1 0.0088 0.0683 0.0507
Schistosoma mansoni alpha-1 adrenergic receptor 0.0088 0.0683 0.0507
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0504 0.0305
Schistosoma mansoni neuropeptide f receptor 76f 0.0088 0.0683 0.0507
Onchocerca volvulus 0.0088 0.0683 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0327 0.0106
Echinococcus granulosus sex peptide receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni biogenic amine receptor 0.0088 0.0683 0.0507
Schistosoma mansoni hypothetical protein 0.0088 0.0683 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.0327 0.0106
Echinococcus granulosus tyrosine protein kinase shark 0.0071 0.0327 0.0096
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0683 0.0507
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.0327 0.0096
Brugia malayi Variant SH3 domain containing protein 0.0108 0.1095 0.097
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Loa Loa (eye worm) TK/FER protein kinase 0.0071 0.0327 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0683 0.0507
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.0327 0.0015
Schistosoma mansoni neuropeptide receptor 0.0088 0.0683 0.0507
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0683 0.0461
Trichomonas vaginalis ras-dva small GTPase, putative 0.0296 0.4995 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0494 0.9114 0.9093
Loa Loa (eye worm) TK protein kinase 0.0386 0.6876 0.6801
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0683 0.0461
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0504 0.4977
Brugia malayi G protein-coupled receptor F59B2.13 0.0088 0.0683 0.0507
Onchocerca volvulus 0.0088 0.0683 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0327 0.0106
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0108 0.1095 0.0882
Loa Loa (eye worm) hypothetical protein 0.0079 0.0504 0.0278
Schistosoma mansoni growth factor receptor-bound protein 0.0108 0.1095 0.097
Brugia malayi neuropeptide F receptor 0.0088 0.0683 0.0507
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0683 0.0461
Echinococcus granulosus tyrosine protein kinase HCK 0.0386 0.6876 0.6801
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0088 0.0683 0.0461
Echinococcus granulosus NCK adaptor protein 0.0108 0.1095 0.0882
Brugia malayi Sex muscle abnormal protein 5 0.0108 0.1095 0.097
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0494 0.9114 0.9093
Onchocerca volvulus 0.0088 0.0683 1
Brugia malayi AKH receptor 0.0088 0.0683 0.0507
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Schistosoma mansoni amine GPCR 0.0088 0.0683 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0327 0.0106
Brugia malayi hypothetical protein 0.0088 0.0683 0.0507
Echinococcus multilocularis growth factor receptor bound protein 2 0.0108 0.1095 0.0882
Echinococcus multilocularis NCK adaptor protein 0.0108 0.1095 0.0882
Entamoeba histolytica Ras family GTPase 0.0296 0.4995 0.7264
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0088 0.0683 0.0461
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0504 0.0305
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0683 0.0461
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.0327 0.0096
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0504 0.0278
Echinococcus multilocularis neuropeptide receptor 0.0088 0.0683 0.0461
Brugia malayi Dopamine receptor protein 2 0.0088 0.0683 0.0507
Trichomonas vaginalis dexras1, putative 0.0296 0.4995 1
Schistosoma mansoni tyrosine kinase 0.0071 0.0327 0.0105
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0088 0.0683 0.0461
Schistosoma mansoni hypothetical protein 0.0088 0.0683 0.0507
Echinococcus granulosus orexin receptor type 2 0.0088 0.0683 0.0461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0683 0.0461
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0327 0.0106
Schistosoma mansoni biogenic amine receptor 0.0088 0.0683 0.0507
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.0954 0.0738
Echinococcus granulosus alpha 1A adrenergic receptor 0.0088 0.0683 0.0461

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.27 uM Inhibitory concentration against human prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 0.27 uM Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2) ChEMBL. 15887968
IC50 (binding) = 0.27 uM Inhibition of human COX2 ChEMBL. 17656360
IC50 (binding) = 0.27 uM Inhibitory concentration against human prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 0.27 uM Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2) ChEMBL. 15887968
IC50 (binding) = 0.27 uM Inhibition of human COX2 ChEMBL. 17656360
IC50 (binding) = 0.59 uM Inhibitory concentration against prostaglandin G/H synthase 1 ChEMBL. 11965379
IC50 (binding) = 0.59 uM Inhibitory concentration against ovine Prostaglandin G/H synthase 1 (COX-1) ChEMBL. 15887968
IC50 (binding) = 0.59 uM Inhibition of ovine COX1 ChEMBL. 17656360
IC50 (binding) = 0.59 uM Inhibitory concentration against prostaglandin G/H synthase 1 ChEMBL. 11965379
IC50 (binding) = 0.59 uM Inhibitory concentration against ovine Prostaglandin G/H synthase 1 (COX-1) ChEMBL. 15887968
IC50 (binding) = 0.59 uM Inhibition of ovine COX1 ChEMBL. 17656360
IC50 (binding) = 60 uM Inhibitory concentration of the compound against R120A mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 60 uM Inhibitory concentration of the compound against R120A mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 75 uM Inhibitory concentration of the compound against R120Q mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 75 uM Inhibitory concentration of the compound against R120Q mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 85 uM Inhibitory concentration of the compound against V891 mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 85 uM Inhibitory concentration of the compound against V891 mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 110 uM Inhibitory concentration of the compound against VRV, mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 110 uM Inhibitory concentration of the compound against VRV, mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 150 uM Inhibitory concentration of the compound against S530A mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 150 uM Inhibitory concentration of the compound against S530A mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 160 uM Inhibitory concentration of the compound against l503F mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 160 uM Inhibitory concentration of the compound against l503F mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 170 uM Inhibitory concentration of the compound against wild type murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 170 uM Inhibitory concentration of the compound against wild type murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 200 uM Inhibitory concentration of the compound against I92L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 200 uM Inhibitory concentration of the compound against S119V mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 200 uM Inhibitory concentration of the compound against I92L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 200 uM Inhibitory concentration of the compound against S119V mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 210 uM Inhibitory concentration of the compound against Y115L/S119V mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 210 uM Inhibitory concentration of the compound against Y115L/S119V mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 220 uM Inhibitory concentration of the compound against V5231, mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 220 uM Inhibitory concentration of the compound against E524L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 220 uM Inhibitory concentration of the compound against V5231, mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 220 uM Inhibitory concentration of the compound against E524L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 250 uM Inhibitory concentration of the compound against F357L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 250 uM Inhibitory concentration of the compound against F357L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 300 uM Inhibitory concentration of the compound against H122N mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 300 uM Inhibitory concentration of the compound against H122N mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 390 uM Inhibitory concentration of the compound against Y115L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
IC50 (binding) = 390 uM Inhibitory concentration of the compound against Y115L mutant murine Prostaglandin G/H synthase 2 ChEMBL. 11965379
Ratio (binding) = 2.2 Ratio of inhibitory concentration of prostaglandin G/H synthase 1 to prostaglandin G/H synthase 2 ChEMBL. 11965379
Ratio (binding) = 2.2 Ratio of inhibitory concentration of prostaglandin G/H synthase 1 to prostaglandin G/H synthase 2 ChEMBL. 11965379

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.