Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sentrin specific protease 7 | 0.0015 | 0.0428 | 0.124 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0015 | 0.0428 | 0.124 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0055 | 0.3457 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0015 | 0.0428 | 0.5 |
Trypanosoma cruzi | SUMO1/Ulp2, putative | 0.0015 | 0.0428 | 0.5 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0015 | 0.0428 | 0.124 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0015 | 0.0428 | 0.124 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0055 | 0.3457 | 1 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0015 | 0.0428 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0428 | 0.0428 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0015 | 0.0428 | 0.0428 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0015 | 0.0428 | 0.0428 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0055 | 0.3457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0428 | 0.0428 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0055 | 0.3457 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0055 | 0.3457 | 0.3457 |
Trypanosoma brucei | SUMO1/Ulp2, putative | 0.0015 | 0.0428 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0015 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 1 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0015 | 0.0428 | 0.124 |
Leishmania major | SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative | 0.0015 | 0.0428 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.0428 | 0.5 | |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0055 | 0.3457 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0015 | 0.0428 | 0.0428 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C48, putative | 0.0015 | 0.0428 | 0.5 |
Giardia lamblia | Sentrin specific protease, putative | 0.0015 | 0.0428 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 1 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0055 | 0.3457 | 1 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0055 | 0.3457 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0055 | 0.3457 | 1 |
Chlamydia trachomatis | deubiquitinase/deneddylase Dub1 | 0.0015 | 0.0428 | 0.5 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0055 | 0.3457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3457 | 0.3457 |
Chlamydia trachomatis | deubiquitinase/deneddylase Dub2 | 0.0015 | 0.0428 | 0.5 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0015 | 0.0428 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 182 nM | In vitro inhibitory activity against Factor Xa | ChEMBL. | 15225723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.