TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.909 | Formula: C23H25ClN2O4
H donors: 2 H acceptors: 3 LogP: 3.69 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCC(NC(=O)Cc1c(C)n(c2c1cc(OC)cc2)C(=O)c1ccc(cc1)Cl)(C)C
InChi: 1S/C23H25ClN2O4/c1-14-18(12-21(28)25-23(2,3)13-27)19-11-17(30-4)9-10-20(19)26(14)22(29)15-5-7-16(24)8-6-15/h5-11,27H,12-13H2,1-4H3,(H,25,28)
InChiKey: MBLSUSPJGSASBD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Starlite/ChEMBL	References
Ovis aries	Cyclooxygenase-1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	neuropeptide receptor	0.0088	0.0683	0.0507
Brugia malayi	Animal haem peroxidase family protein	0.0079	0.0504	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Echinococcus multilocularis	neuropeptide Y receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	tyrosine protein kinase Srms	0.0071	0.0327	0.0096
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0071	0.0327	0.0096
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0327	0.0105
Schistosoma mansoni	hypothetical protein	0.0088	0.0683	0.0507
Onchocerca volvulus		0.0088	0.0683	1
Entamoeba histolytica	Ras family GTPase	0.0296	0.4995	0.7264
Schistosoma mansoni	tyrosine kinase	0.0124	0.1431	0.135
Brugia malayi	SH2 domain containing protein	0.0071	0.0327	0.0105
Schistosoma mansoni	growth factor receptor-bound protein	0.0108	0.1095	0.097
Schistosoma mansoni	growth hormone secretagogue receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	opsin-like receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	adenoreceptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	TYRA-2 protein	0.0088	0.0683	0.0461
Echinococcus granulosus	neuropeptide receptor A26	0.0088	0.0683	0.0461
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Brugia malayi	Blistered cuticle protein 3	0.0079	0.0504	0.0305
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0071	0.0327	0.0096
Echinococcus granulosus	c src tyrosine kinase	0.0124	0.1431	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	neuropeptide F-like receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	somatostatin receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0088	0.0683	0.0461
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0071	0.0327	0.0096
Echinococcus granulosus	FTZ F1 alpha	0.0071	0.0327	0.0096
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0071	0.0327	0.0106
Echinococcus multilocularis	serotonin receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	tyrosine kinase	0.0101	0.0954	0.0812
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Schistosoma mansoni	tyrosine kinase	0.0494	0.9114	1
Schistosoma mansoni	adapter molecule crk	0.0108	0.1095	0.097
Onchocerca volvulus	Chorion peroxidase homolog	0.0079	0.0504	0.4977
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus multilocularis	G protein coupled receptor 139	0.0088	0.0683	0.0461
Echinococcus granulosus	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	neuropeptides capa receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	serotonin receptor	0.0088	0.0683	0.0461
Brugia malayi	Melatonin receptor type 1A	0.0088	0.0683	0.0507
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0302	0.513	0.5014
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	fmrfamide receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0071	0.0327	0.0096
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus multilocularis	g protein coupled receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0386	0.6876	0.6801
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0079	0.0505	0.5
Echinococcus granulosus	dual specificity mitogen activated protein	0.0079	0.0505	0.0279
Onchocerca volvulus	Peroxidase homolog	0.0079	0.0504	0.4977
Echinococcus granulosus	neuropeptides capa receptor	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0071	0.0327	0.0106
Echinococcus granulosus	serotonin receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	ras gtpase	0.0296	0.4995	0.4876
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0537	1	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0108	0.1095	0.0882
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0071	0.0327	0.0096
Brugia malayi	ecdysteroid receptor	0.0071	0.0327	0.0106
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0088	0.0683	0.0461
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	blistered cuticle protein 3	0.0079	0.0504	0.0278
Brugia malayi	Ras protein let-60	0.0296	0.4995	0.5362
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0079	0.0505	0.0306
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	neuropeptide receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0088	0.0683	0.0461
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0088	0.0683	0.0507
Echinococcus multilocularis	g-protein coupled receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	tyrosine kinase	0.0482	0.8867	0.9722
Onchocerca volvulus		0.0088	0.0683	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0071	0.0327	0.0106
Onchocerca volvulus		0.0088	0.0683	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Schistosoma mansoni	amine GPCR	0.0088	0.0683	0.0507
Schistosoma mansoni	protein kinase	0.0079	0.0505	0.0306
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	7tm_1 domain containing protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0071	0.0327	0.0106
Echinococcus granulosus	tm gpcr rhodopsin	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0071	0.0327	0.0106
Schistosoma mansoni	tyrosine kinase	0.0085	0.0617	0.0433
Echinococcus multilocularis	neuropeptide s receptor	0.0088	0.0683	0.0461
Brugia malayi	RE15519p	0.0088	0.0683	0.0507
Schistosoma mansoni	opsin-like receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0088	0.0683	0.0461
Schistosoma mansoni	nuclear hormone receptor	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0088	0.0683	0.0507
Loa Loa (eye worm)	G-protein coupled receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Echinococcus multilocularis	ras gtpase	0.0296	0.4995	0.4876
Echinococcus granulosus	epidermal growth factor receptor	0.0101	0.0954	0.0738
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0088	0.0683	0.0461
Schistosoma mansoni	biogenic amine receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Brugia malayi	GnHR receptor homolog	0.0088	0.0683	0.0507
Loa Loa (eye worm)	TK protein kinase	0.0441	0.8009	0.7961
Echinococcus granulosus	neuropeptide receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	histamine h1 receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0298	0.0074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0071	0.0327	0.0096
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0071	0.0327	0.0106
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0327	0.0105
Echinococcus multilocularis	orexin receptor type 2	0.0088	0.0683	0.0461
Loa Loa (eye worm)	neuropeptide F receptor	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0071	0.0327	0.0106
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	neuropeptides capa receptor	0.0088	0.0683	0.0461
Brugia malayi	larval opioid receptor	0.0088	0.0683	0.0507
Onchocerca volvulus	Peroxidasin homolog	0.0079	0.0504	0.4977
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0088	0.0683	0.0507
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Loa Loa (eye worm)	animal heme peroxidase	0.0079	0.0504	0.0278
Entamoeba histolytica	protein kinase, putative	0.0386	0.6876	1
Trichomonas vaginalis	rap1 and, putative	0.0296	0.4995	1
Schistosoma mansoni	tyrosine kinase	0.0175	0.2486	0.2537
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0088	0.0683	0.0507
Brugia malayi	putative neuropeptide receptor	0.0088	0.0683	0.0507
Onchocerca volvulus		0.0079	0.0504	0.4977
Loa Loa (eye worm)	animal heme peroxidase	0.0079	0.0504	0.0278
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0495	0.9124	0.9103
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0425	0.7672	0.7617
Echinococcus granulosus	g protein coupled receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	epidermal growth factor receptor	0.0101	0.0954	0.0738
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	hypothetical protein	0.0071	0.0327	0.0105
Loa Loa (eye worm)	SRC-1	0.0494	0.9114	0.9093
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0441	0.8009	0.7961
Brugia malayi	Ras-related protein R-Ras2	0.0296	0.4995	0.5362
Echinococcus granulosus	neuropeptide s receptor	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0071	0.0327	0.0106
Echinococcus granulosus	tm gpcr rhodopsin	0.0088	0.0683	0.0461
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0071	0.0327	0.0096
Schistosoma mansoni	tyrosine kinase	0.0124	0.1431	0.135
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Onchocerca volvulus	Peroxidase homolog	0.0079	0.0504	0.4977
Echinococcus multilocularis	neuropeptide Y receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Giardia lamblia	Kinase, STE STE20	0.0079	0.0505	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0124	0.1431	0.135
Schistosoma mansoni	thyroid hormone receptor	0.0071	0.0327	0.0106
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Brugia malayi	neuropeptide F receptor	0.0088	0.0683	0.0507
Echinococcus granulosus	growth factor receptor bound protein 2	0.0108	0.1095	0.0882
Brugia malayi	Serotonin receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0071	0.0327	0.0096
Entamoeba histolytica	ras-1, putative	0.0296	0.4995	0.7264
Onchocerca volvulus		0.0079	0.0504	0.4977
Loa Loa (eye worm)	TK/ABL protein kinase	0.0537	1	1
Schistosoma mansoni	nck2/grb4	0.0108	0.1095	0.097
Echinococcus multilocularis	allatostatin A receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0071	0.0327	0.0106
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0071	0.0327	0.0096
Brugia malayi	Serotonin receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0071	0.0327	0.0096
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0327	0.0105
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Schistosoma mansoni	tyrosine kinase	0.0085	0.0617	0.0433
Echinococcus granulosus	neuropeptide Y receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0088	0.0683	0.0461
Brugia malayi	Animal haem peroxidase family protein	0.0079	0.0504	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0494	0.9114	0.9093
Echinococcus multilocularis	tyrosine protein kinase shark	0.0071	0.0327	0.0096
Brugia malayi	G protein-coupled receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0088	0.0683	0.0507
Trichomonas vaginalis	ral, putative	0.0296	0.4995	1
Brugia malayi	steroid hormone receptor	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0194	0.2892	0.2723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	melatonin receptor type 1A	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0494	0.9114	0.9093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0296	0.4995	0.4876
Schistosoma mansoni	amine GPCR	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	g-protein coupled receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Brugia malayi	SRC-1	0.0494	0.9114	1
Onchocerca volvulus		0.0088	0.0683	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0071	0.0327	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Onchocerca volvulus		0.0088	0.0683	1
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0071	0.0327	0.0096
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0079	0.0505	0.0279
Brugia malayi	putative neuropeptide receptor NPR1	0.0088	0.0683	0.0507
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	neuropeptides capa receptor	0.0088	0.0683	0.0461
Brugia malayi	Furin-like cysteine rich region family protein	0.0175	0.2486	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1095	0.0882
Schistosoma mansoni	opsin-like receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0327	0.0105
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0071	0.0327	0.0096
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0494	0.9114	0.9093
Echinococcus multilocularis	dro:myosuppressin receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0108	0.1095	0.097
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0441	0.8009	0.7961
Schistosoma mansoni	neuropeptide F-like receptor	0.0088	0.0683	0.0507
Brugia malayi	follicle stimulating hormone receptor	0.0088	0.0683	0.0507
Brugia malayi	G-protein coupled receptor	0.0088	0.0683	0.0507
Brugia malayi	protein-tyrosine kinase	0.0441	0.8009	0.8756
Brugia malayi	G-protein coupled receptor	0.0088	0.0683	0.0507
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0124	0.1431	0.1227
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Onchocerca volvulus		0.0088	0.0683	1
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0071	0.0327	0.0096
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0071	0.0327	0.0106
Loa Loa (eye worm)	Ras protein let-60	0.0296	0.4995	0.4876
Schistosoma mansoni	amine GPCR	0.0088	0.0683	0.0507
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0071	0.0327	0.0096
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0441	0.8009	0.7961
Trichomonas vaginalis	rheb, putative	0.0296	0.4995	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Echinococcus granulosus	neuropeptide Y receptor	0.0088	0.0683	0.0461
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0296	0.4995	1
Loa Loa (eye worm)	animal heme peroxidase	0.0079	0.0504	0.0278
Loa Loa (eye worm)	steroid hormone receptor	0.0071	0.0327	0.0096
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0079	0.0505	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0071	0.0327	0.0475
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	peroxidasin	0.0079	0.0504	0.0278
Echinococcus granulosus	neuropeptide receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	c src tyrosine kinase	0.0124	0.1431	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Echinococcus multilocularis	g protein coupled receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	sulfakinin receptor protein	0.0088	0.0683	0.0507
Echinococcus granulosus	7TM GPCR rhodopsin	0.0088	0.0683	0.0461
Schistosoma mansoni	neuropeptide receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0088	0.0683	0.0461
Brugia malayi	photoreceptor-specific nuclear receptor	0.0071	0.0327	0.0106
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	G protein coupled receptor 139	0.0088	0.0683	0.0461
Schistosoma mansoni	tyrosine kinase	0.0101	0.0954	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	tyrosine kinase	0.0071	0.0327	0.0105
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0071	0.0327	0.0106
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Onchocerca volvulus		0.0088	0.0683	1
Schistosoma mansoni	tyrosine kinase	0.0085	0.0617	0.0433
Echinococcus granulosus	g protein coupled receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	tyrosine kinase	0.0494	0.9114	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0494	0.9114	0.9093
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0088	0.0683	0.0507
Brugia malayi	Peroxidasin	0.0079	0.0504	0.0305
Onchocerca volvulus	Peroxidasin homolog	0.0079	0.0504	0.4977
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0088	0.0683	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0327	0.0105
Schistosoma mansoni	coup transcription factor	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0494	0.9114	0.9093
Echinococcus multilocularis	tyrosine kinase	0.0071	0.0327	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0071	0.0327	0.0106
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0425	0.7672	0.7617
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0071	0.0327	0.0096
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0071	0.0327	0.0096
Echinococcus granulosus	epidermal growth factor receptor	0.0175	0.2486	0.2307
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0071	0.0327	0.0106
Echinococcus multilocularis	peroxidasin	0.0079	0.0504	0.0278
Echinococcus granulosus	allatostatin A receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	nuclear receptor NHR-88	0.0071	0.0327	0.0106
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0088	0.0683	1
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0079	0.0505	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	peroxidasin	0.0079	0.0504	0.0305
Brugia malayi	Steroid receptor seven-up type 2	0.0071	0.0327	0.0106
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0175	0.2486	0.2307
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0494	0.9114	0.9093
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0124	0.1431	0.1227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0494	0.9114	0.9093
Brugia malayi	ORL1-like opioid receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	sex peptide receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0071	0.0327	0.0096
Echinococcus granulosus	tyrosine protein kinase Blk	0.0441	0.8009	0.7961
Echinococcus multilocularis	g protein coupled receptor	0.0088	0.0683	0.0461
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus multilocularis	neuropeptide receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Brugia malayi	hypothetical protein	0.0079	0.0504	0.0305
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0088	0.0683	0.0461
Onchocerca volvulus		0.0079	0.0504	0.4977
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0088	0.0683	0.0461
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	somatostatin receptor	0.0088	0.0683	0.0461
Brugia malayi	Tyrosine-protein kinase abl-1	0.0302	0.513	0.5514
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0071	0.0327	0.0106
Brugia malayi	nuclear hormone receptor	0.0071	0.0327	0.0106
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0441	0.8009	0.7961
Schistosoma mansoni	peroxidasin	0.0079	0.0504	0.0305
Schistosoma mansoni	myosin xvIII	0.0088	0.0683	0.0507
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	ecdysone induced protein 78C	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0494	0.9114	0.9093
Schistosoma mansoni	RAR-like nuclear receptor	0.0071	0.0327	0.0106
Brugia malayi	Variant SH3 domain containing protein	0.0108	0.1095	0.097
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0088	0.0683	0.0461
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0088	0.0683	0.0507
Echinococcus granulosus	ecdysone induced protein 78C	0.0071	0.0327	0.0096
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0088	0.0683	0.0461
Onchocerca volvulus		0.0071	0.0327	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0088	0.0683	0.0507
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0494	0.9114	0.9093
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Loa Loa (eye worm)	G-protein coupled receptor	0.0088	0.0683	0.0461
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0071	0.0327	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus granulosus	tm gpcr rhodopsin	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Brugia malayi	Animal haem peroxidase family protein	0.0079	0.0504	0.0305
Onchocerca volvulus		0.0088	0.0683	1
Onchocerca volvulus	Bile acid receptor homolog	0.0071	0.0327	0.0015
Brugia malayi	Tyrosine-protein kinase abl-1	0.0288	0.4832	0.5178
Echinococcus multilocularis	neuropeptide receptor A26	0.0088	0.0683	0.0461
Echinococcus multilocularis	epidermal growth factor receptor	0.0175	0.2486	0.2307
Echinococcus multilocularis	fmrfamide receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Echinococcus granulosus	g protein coupled receptor	0.0088	0.0683	0.0461
Brugia malayi	SH2 domain containing protein	0.0071	0.0327	0.0105
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus multilocularis	fmrfamide receptor	0.0088	0.0683	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0071	0.0327	0.0106
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Echinococcus granulosus	neuropeptide FF receptor 2	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0327	0.0096
Schistosoma mansoni	amine GPCR	0.0088	0.0683	0.0507
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0079	0.0505	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0071	0.0327	0.0096
Echinococcus granulosus	tyrosine kinase	0.0441	0.8009	0.7961
Schistosoma mansoni	growth factor receptor-bound protein	0.0108	0.1095	0.097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0504	0.0278
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0108	0.1095	0.0882
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0071	0.0327	0.0106
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Onchocerca volvulus	Dual oxidase homolog	0.0079	0.0504	0.4977
Brugia malayi	G protein-coupled receptor F59B2.13	0.0088	0.0683	0.0507
Onchocerca volvulus		0.0088	0.0683	1
Loa Loa (eye worm)	TK protein kinase	0.0386	0.6876	0.6801
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0494	0.9114	0.9093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0296	0.4995	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0494	0.9114	0.9093
Onchocerca volvulus		0.0088	0.0683	1
Brugia malayi	Sex muscle abnormal protein 5	0.0108	0.1095	0.097
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0088	0.0683	0.0461
Echinococcus granulosus	NCK adaptor protein	0.0108	0.1095	0.0882
Echinococcus granulosus	tyrosine protein kinase HCK	0.0386	0.6876	0.6801
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	neuropeptide F receptor	0.0088	0.0683	0.0507
Echinococcus multilocularis	neuropeptide receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0071	0.0327	0.0096
Echinococcus granulosus	biogenic amine 5HT receptor	0.0088	0.0683	0.0461
Loa Loa (eye worm)	animal heme peroxidase	0.0079	0.0504	0.0278
Brugia malayi	Animal haem peroxidase family protein	0.0079	0.0504	0.0305
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0088	0.0683	0.0461
Entamoeba histolytica	Ras family GTPase	0.0296	0.4995	0.7264
Echinococcus multilocularis	NCK adaptor protein	0.0108	0.1095	0.0882
Brugia malayi	Nuclear hormone receptor-like 1	0.0071	0.0327	0.0106
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0108	0.1095	0.0882
Brugia malayi	hypothetical protein	0.0088	0.0683	0.0507
Schistosoma mansoni	amine GPCR	0.0088	0.0683	0.0507
Brugia malayi	AKH receptor	0.0088	0.0683	0.0507
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0101	0.0954	0.0738
Schistosoma mansoni	biogenic amine receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	thyroid hormone receptor	0.0071	0.0327	0.0106
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0088	0.0683	0.0461
Echinococcus granulosus	orexin receptor type 2	0.0088	0.0683	0.0461
Schistosoma mansoni	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0088	0.0683	0.0461
Schistosoma mansoni	tyrosine kinase	0.0071	0.0327	0.0105
Trichomonas vaginalis	dexras1, putative	0.0296	0.4995	1
Brugia malayi	Dopamine receptor protein 2	0.0088	0.0683	0.0507
Loa Loa (eye worm)	neuropeptide F receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0088	0.0683	0.0461
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0088	0.0683	0.0461
Brugia malayi	Dopamine receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	neuropeptide f receptor 76f	0.0088	0.0683	0.0507
Brugia malayi	Animal haem peroxidase family protein	0.0079	0.0504	0.0305
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0088	0.0683	0.0507
Brugia malayi	Dopamine receptor protein 1	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	biogenic amine receptor	0.0088	0.0683	0.0507
Schistosoma mansoni	hypothetical protein	0.0088	0.0683	0.0507
Echinococcus granulosus	sex peptide receptor	0.0088	0.0683	0.0461
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0071	0.0327	0.0106
Onchocerca volvulus		0.0088	0.0683	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0088	0.0683	0.0461
Onchocerca volvulus	Protein ultraspiracle homolog	0.0071	0.0327	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0088	0.0683	0.0507
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0088	0.0683	0.0461
Schistosoma mansoni	neuropeptide receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0088	0.0683	0.0461
Echinococcus multilocularis	FTZ F1 alpha	0.0071	0.0327	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0683	0.0461
Brugia malayi	Variant SH3 domain containing protein	0.0108	0.1095	0.097
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0088	0.0683	0.0507
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.0327	0.0096
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0088	0.0683	0.0461
Echinococcus granulosus	tyrosine protein kinase shark	0.0071	0.0327	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0071	0.0327	0.0106

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.19 uM	Inhibitory concentration against human prostaglandin G/H synthase 2	ChEMBL.	11965379
IC50 (binding)	= 0.19 uM	Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2)	ChEMBL.	15887968
IC50 (binding)	= 0.19 uM	Inhibitory concentration against human prostaglandin G/H synthase 2	ChEMBL.	11965379
IC50 (binding)	= 0.19 uM	Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2)	ChEMBL.	15887968
IC50 (binding)	= 0.8 uM	Inhibitory concentration against prostaglandin G/H synthase 1	ChEMBL.	11965379
IC50 (binding)	= 0.8 uM	Inhibitory concentration against ovine Prostaglandin G/H synthase 1 (COX-1)	ChEMBL.	15887968
IC50 (binding)	= 0.8 uM	Inhibitory concentration against prostaglandin G/H synthase 1	ChEMBL.	11965379
IC50 (binding)	= 0.8 uM	Inhibitory concentration against ovine Prostaglandin G/H synthase 1 (COX-1)	ChEMBL.	15887968
Ratio (binding)	= 4.2	Ratio of inhibitory concentration of prostaglandin G/H synthase 1 to prostaglandin G/H synthase 2	ChEMBL.	11965379
Ratio (binding)	= 4.2	Ratio of inhibitory concentration of prostaglandin G/H synthase 1 to prostaglandin G/H synthase 2	ChEMBL.	11965379

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL433427

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 32390