Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Brugia malayi | Amino acid permease family protein | 0.0049 | 0.0402 | 0.0902 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0226 | 0.4452 | 0.4452 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0049 | 0.0402 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0226 | 0.4452 | 0.4452 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0226 | 0.4452 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0226 | 0.4452 | 0.4452 |
Trichomonas vaginalis | immunophilin, putative | 0.0226 | 0.4452 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0226 | 0.4452 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Schistosoma mansoni | immunophilin | 0.0195 | 0.3742 | 0.8404 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0226 | 0.4452 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0226 | 0.4452 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0226 | 0.4452 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0226 | 0.4452 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0226 | 0.4452 | 0.4452 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0195 | 0.3742 | 0.3742 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0226 | 0.4452 | 1 |
Schistosoma mansoni | immunophilin | 0.0226 | 0.4452 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0031 | 0 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0226 | 0.4452 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0226 | 0.4452 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0226 | 0.4452 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Schistosoma mansoni | immunophilin | 0.0226 | 0.4452 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0226 | 0.4452 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0226 | 0.4452 | 1 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.0049 | 0.0402 | 0.0902 |
Loa Loa (eye worm) | amino acid permease | 0.0049 | 0.0402 | 0.0902 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0226 | 0.4452 | 1 |
Echinococcus granulosus | solute carrier family 12 | 0.0049 | 0.0402 | 0.0402 |
Echinococcus multilocularis | solute carrier family 12 | 0.0049 | 0.0402 | 0.0402 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0226 | 0.4452 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0226 | 0.4452 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0195 | 0.3742 | 0.3742 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.3742 | 0.8404 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0226 | 0.4452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0402 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0226 | 0.4452 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0226 | 0.4452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0243 | 0.0547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 1.3 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 40 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 40 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.