Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0638 | 0.0638 |
Echinococcus multilocularis | musashi | 0.003 | 0.0638 | 0.2772 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.019 | 0.7133 | 0.7133 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2302 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0032 | 0.0704 | 0.306 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.7133 | 0.7133 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0032 | 0.0704 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2302 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0032 | 0.0704 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2302 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2302 | 0.2302 |
Echinococcus multilocularis | lamin | 0.003 | 0.0638 | 0.2772 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0032 | 0.0704 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.0032 | 0.0704 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0032 | 0.0704 | 0.306 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.7133 | 0.7133 |
Echinococcus multilocularis | multidrug resistance associated protein 4 | 0.0024 | 0.0403 | 0.175 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0032 | 0.0704 | 1 |
Toxoplasma gondii | hypothetical protein | 0.019 | 0.7133 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0032 | 0.0704 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0032 | 0.0704 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0694 | 0.0694 |
Schistosoma mansoni | multidrug resistance protein | 0.0032 | 0.0704 | 0.0399 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0638 | 0.2561 |
Leishmania major | ABC-thiol transporter | 0.0032 | 0.0704 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0032 | 0.0704 | 0.2857 |
Onchocerca volvulus | 0.003 | 0.0638 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0763 | 0.3119 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2302 | 0.2302 |
Giardia lamblia | MRP-like ABC transporter | 0.0032 | 0.0704 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2302 | 0.2302 |
Brugia malayi | multidrug resistance related protein 1 | 0.0032 | 0.0704 | 0.2857 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.0704 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2302 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0032 | 0.0704 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2302 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0032 | 0.0704 | 0.306 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0615 | 0.0615 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0032 | 0.0704 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0032 | 0.0704 | 0.0704 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2302 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0032 | 0.0704 | 0.0399 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0032 | 0.0704 | 1 |
Onchocerca volvulus | 0.003 | 0.0638 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0638 | 0.2772 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2302 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0638 | 0.0638 |
Leishmania major | p-glycoprotein e | 0.0032 | 0.0704 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0763 | 0.0763 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0032 | 0.0704 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0032 | 0.0704 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2302 | 1 |
Echinococcus granulosus | lamin | 0.003 | 0.0638 | 0.2772 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0638 | 0.2772 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0032 | 0.0704 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0032 | 0.0704 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0032 | 0.0704 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0032 | 0.0704 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0032 | 0.0704 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0638 | 0.2772 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0032 | 0.0704 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0032 | 0.0704 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.7133 | 0.7133 |
Schistosoma mansoni | multidrug resistance protein | 0.0032 | 0.0704 | 0.0399 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0032 | 0.0704 | 0.306 |
Echinococcus granulosus | multidrug resistance associated protein 4 | 0.0024 | 0.0403 | 0.175 |
Schistosoma mansoni | multidrug resistance protein | 0.0032 | 0.0704 | 0.0399 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0032 | 0.0704 | 0.5 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0025 | 0.0413 | 0.0413 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2302 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0032 | 0.0704 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0704 | 0.0704 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0638 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0704 | 0.0704 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2302 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | = 32 % | The antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 3 h for a dose of 75 mg/kg po | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | = 40 % | The antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 4 h for a dose of 75 mg/kg po | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | = 43 % | The antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 2 h for a dose of 75 mg/kg po | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | = 47 % | The antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 1 h for a dose of 75 mg/kg po | ChEMBL. | 7310808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.