Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melatonin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | melatonin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melatonin receptor 1B | 362 aa | 329 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0053 | 0.7243 | 0.7302 |
Echinococcus multilocularis | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0053 | 0.7243 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0053 | 0.7243 | 0.7243 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Echinococcus granulosus | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Loa Loa (eye worm) | haspin protein kinase | 0.0068 | 0.9918 | 0.9918 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Brugia malayi | GSG2 | 0.0068 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0053 | 0.7243 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0068 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0053 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0068 | 0.9918 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0053 | 0.7243 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0053 | 0.7243 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.0068 | 0.9918 | 0.9918 |
Echinococcus multilocularis | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Echinococcus granulosus | dual specificity | 0.0053 | 0.7243 | 0.7302 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.7243 | 0.7302 |
Entamoeba histolytica | protein kinase, putative | 0.0053 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0053 | 0.7243 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0068 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.7243 | 1 |
Brugia malayi | hypothetical protein | 0.0068 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0068 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0068 | 0.9918 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.9918 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 79 nM | Inhibitory concentration against Melatonin receptor type 1B | ChEMBL. | 15501061 |
IC50 (binding) | = 79 nM | Inhibitory concentration against Melatonin receptor type 1B | ChEMBL. | 15501061 |
IC50 (binding) | > 1000 nM | Inhibitory concentration against Melatonin receptor type 1A | ChEMBL. | 15501061 |
IC50 (binding) | > 1000 nM | Inhibitory concentration against Melatonin receptor type 1A | ChEMBL. | 15501061 |
Ratio (binding) | > 12 | Ratio of inhibitory concentration against Melatonin receptor type 1B to that of Melatonin receptor type 1A | ChEMBL. | 15501061 |
Ratio (binding) | > 12 | Ratio of inhibitory concentration against Melatonin receptor type 1B to that of Melatonin receptor type 1A | ChEMBL. | 15501061 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.