Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0386 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0247 | 0.0247 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0247 | 0.5 |
Brugia malayi | Melibiase family protein | 0.0067 | 0.1526 | 0.1526 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0247 | 0.0247 |
Brugia malayi | hypothetical protein | 0.0299 | 0.7676 | 0.7676 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0533 | 0.0533 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0386 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0247 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0247 | 0.0247 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0247 | 0.0247 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0386 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Toxoplasma gondii | Alpha-galactosidase | 0.0014 | 0.0136 | 0.0136 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0533 | 0.0533 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0247 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0504 | 0.0504 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.1526 | 0.1526 |
Onchocerca volvulus | 0.0231 | 0.588 | 0.7486 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 0.7676 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0386 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0386 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0247 | 0.0247 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0533 | 0.0533 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0386 | 1 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0533 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0386 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0533 | 0.0533 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0533 | 0.0533 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0533 | 0.0533 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0247 | 0.0247 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.588 | 0.5776 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0386 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.7676 | 0.7676 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0067 | 0.1526 | 0.1311 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0014 | 0.0136 | 0.0136 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0386 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0247 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0247 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0386 | 1 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.01 | 0.2407 | 0.2407 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0386 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0247 | 0.4644 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0386 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0533 | 0.0533 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0386 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.5137 | 0.5137 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0247 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0247 | 0.0247 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0386 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0386 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.1526 | 0.1526 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0247 | 0.0247 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.2407 | 0.2407 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.01 | 0.2407 | 0.2407 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0533 | 0.0533 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0386 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0533 | 0.0533 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0533 | 0.0533 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.5137 | 0.5137 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1526 | 0.1526 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0386 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | NA 0 % | Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 2 h for a dose of 50 mg/kg | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | NA 0 % | Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 3 h for a dose of 50 mg/kg | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | NA 0 % | Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 4 h for a dose of 50 mg/kg | ChEMBL. | 7310808 |
Decrease in blood pressure (functional) | = 21 % | Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats after a period of 1 h for a dose of 50 mg/kg | ChEMBL. | 7310808 |
logD (ADMET) | = 0 | 1-Octanol distribution coefficient in spontaneously hypertensive rats for a dose of 50 mg/kg po; No data | ChEMBL. | 7310808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.