TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.373 | Formula: C22H14N4
H donors: 0 H acceptors: 2 LogP: 3.96 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)/N=C/c1ccc(cc1)/C=N/c1ccc(cc1)C#N
InChi: 1S/C22H14N4/c23-13-17-5-9-21(10-6-17)25-15-19-1-2-20(4-3-19)16-26-22-11-7-18(14-24)8-12-22/h1-12,15-16H/b25-15+,26-16+
InChiKey: CPKWIIGGNSBNSB-RYQLWAFASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Trypanosoma brucei	p-glycoprotein	0.0097	0.1534	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0049	0.0687	0.4202
Trypanosoma cruzi	cdc2-related kinase 3	0.0049	0.0687	0.3551
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0022	0.022	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0049	0.0687	0.0619
Entamoeba histolytica	ABC transporter, putative	0.0097	0.1534	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0097	0.1534	0.1344
Trypanosoma cruzi	cdc2-related kinase 1	0.0049	0.0687	0.3551
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0097	0.1534	1
Giardia lamblia	Kinase, CMGC CDK	0.0049	0.0687	0.3619
Brugia malayi	ABC transporter transmembrane region family protein	0.0022	0.0206	0.0245
Brugia malayi	hypothetical protein	0.0022	0.022	0.027
Schistosoma mansoni	protein kinase	0.0064	0.0949	0.6
Entamoeba histolytica	protein kinase , putative	0.0064	0.0949	0.6189
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0022	0.022	0.1009
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0022	0.022	0.0186
Echinococcus multilocularis	cyclin dependent kinase 1	0.0049	0.0687	0.4202
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.0022	0.022	0.5
Schistosoma mansoni	multidrug resistance protein	0.0022	0.022	0.1009
Leishmania major	protein kinase, putative	0.0064	0.0949	0.5552
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0949	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0022	0.022	0.1009
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0022	0.0206	0.0914
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0022	0.022	0.1009
Echinococcus granulosus	ATP binding cassette sub family B	0.0022	0.022	0.1009
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Echinococcus multilocularis	cyclin dependent kinase	0.0049	0.0687	0.4202
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Trichomonas vaginalis	abcb9, putative	0.0022	0.022	0.0186
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0097	0.1534	1
Loa Loa (eye worm)	ABC transporter	0.0022	0.022	0.0149
Echinococcus granulosus	cyclin dependent kinase 1	0.0049	0.0687	0.4202
Loa Loa (eye worm)	hypothetical protein	0.0022	0.022	0.0149
Trypanosoma brucei	multidrug resistance protein E	0.0097	0.1534	1
Echinococcus granulosus	cyclin dependent kinase 5	0.0049	0.0687	0.4202
Echinococcus multilocularis		0.0022	0.022	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0206	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1534	0.1472
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.022	0.1009
Brugia malayi	serine/threonine kinase 12	0.0064	0.0949	0.1605
Schistosoma mansoni	multidrug resistance protein	0.0022	0.022	0.1009
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0949	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0049	0.0687	0.0619
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0049	0.0687	0.0477
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0687	0.6464
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0022	0.022	0.0186
Brugia malayi	ABC transporter transmembrane region family protein	0.0097	0.1534	0.2674
Entamoeba histolytica	P-glycoprotein 6, putative	0.0022	0.022	0.1434
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0022	0.022	0.1009
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0049	0.0687	0.0619
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0097	0.1534	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0022	0.022	0.1434
Echinococcus multilocularis	cyclin dependent kinase 1	0.0049	0.0687	0.4202
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.022	0.0186
Giardia lamblia	ABC transporter, putative	0.0097	0.1534	1
Schistosoma mansoni	multidrug resistance protein	0.0097	0.1534	1
Trypanosoma brucei	cdc2-related kinase 1	0.0049	0.0687	0.3551
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0949	1
Schistosoma mansoni	smdr1	0.0022	0.022	0.1009
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0022	0.022	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0022	0.022	0.1009
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0049	0.0687	0.4202
Leishmania major	ABC-thiol transporter	0.0097	0.1534	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.022	0.0149
Trichomonas vaginalis	taga, putative	0.0022	0.022	0.0186
Plasmodium vivax	protein kinase Crk2	0.0049	0.0687	0.6397
Brugia malayi	multidrug resistance protein 3	0.0022	0.022	0.027
Trichomonas vaginalis	ABC transporter, putative	0.0022	0.022	0.0186
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0064	0.0949	0.6
Echinococcus multilocularis	aurora kinase A	0.0064	0.0949	0.6
Loa Loa (eye worm)	multidrug resistance-associated protein	0.0075	0.1151	0.1086
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0097	0.1534	1
Brugia malayi	serine/threonine-protein kinase 6	0.0064	0.0949	0.1605
Echinococcus granulosus	multidrug resistance protein 1	0.0022	0.022	0.1009
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.022	0.1009
Schistosoma mansoni	multidrug resistance protein	0.0022	0.022	0.1009
Giardia lamblia	Kinase, CMGC CDK	0.0049	0.0687	0.3619
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.022	0.1009
Brugia malayi	serine/threonine protein kinase 6	0.0064	0.0949	0.1605
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0687	0.4202
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0687	0.1124
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0097	0.1534	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0022	0.022	0.1009
Entamoeba histolytica	P-glycoprotein-2, putative	0.0022	0.0206	0.1344
Echinococcus multilocularis	multidrug resistance protein 1	0.0022	0.022	0.1009
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0064	0.0949	1
Toxoplasma gondii	aurora kinase	0.0064	0.0949	0.0746
Trypanosoma brucei	cdc2-related kinase 3	0.0049	0.0687	0.3551
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.022	0.1009
Echinococcus granulosus	ATP binding cassette sub family B	0.0022	0.0206	0.0914
Brugia malayi	ABC transporter family protein	0.0022	0.022	0.027
Loa Loa (eye worm)	AUR protein kinase	0.0064	0.0949	0.0883
Echinococcus multilocularis	multidrug resistance protein 1	0.0022	0.022	0.1009
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0949	0.6
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0022	0.022	0.5
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0074	0.1137	0.7282
Entamoeba histolytica	cell division protein kinase 2, putative	0.0049	0.0687	0.4476
Loa Loa (eye worm)	ABC transporter	0.0022	0.022	0.0149
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0097	0.1534	1
Entamoeba histolytica	P-glycoprotein-2	0.0022	0.022	0.1434
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0097	0.1534	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.022	0.0186
Echinococcus granulosus	multidrug resistance protein 1	0.0022	0.022	0.1009
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0687	0.4202
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0.022	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Trypanosoma brucei	aurora B kinase	0.0064	0.0949	0.5552
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.0949	0.6189
Trichomonas vaginalis	ABC transporter, putative	0.0022	0.022	0.0186
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0015	0.0091	0.0125
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.022	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0206	0.0135
Brugia malayi	cell division control protein 2 homolog	0.0049	0.0687	0.1124
Leishmania major	pentamidine resistance protein 1	0.0097	0.1534	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0014	0.0072	0.0472
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.022	0.0186
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0022	0.022	0.027
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0049	0.0687	0.3551
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0097	0.1534	0.1472
Entamoeba histolytica	P-glycoprotein-2	0.0022	0.022	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0668	0.06
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0097	0.1534	1
Trypanosoma cruzi	aurora B kinase, putative	0.0064	0.0949	0.5552
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0022	0.022	0.1009
Entamoeba histolytica	P-glycoprotein-1	0.0022	0.022	0.1434
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0049	0.0687	0.3551
Loa Loa (eye worm)	AUR protein kinase	0.0064	0.0949	0.0883
Entamoeba histolytica	P-glycoprotein-5	0.0022	0.022	0.1434
Giardia lamblia	Multidrug resistance-associated protein 1	0.0096	0.152	0.9896
Schistosoma mansoni	multidrug resistance protein	0.0097	0.1534	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0022	0.022	0.027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.022	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0096	0.152	0.1458
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0097	0.1534	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.0949	0.6189
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0.022	0.5
Toxoplasma gondii	hypothetical protein	0.0576	1	1
Echinococcus granulosus	aurora kinase A	0.0064	0.0949	0.6
Schistosoma mansoni	multidrug resistance protein	0.0097	0.1534	1
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.0022	0.022	0.5
Entamoeba histolytica	P-glycoprotein 5, putative	0.0022	0.0206	0.1344
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0097	0.1534	1
Echinococcus granulosus	multidrug resistance associated protein 7	0.0097	0.1534	1
Trichomonas vaginalis	abcb9, putative	0.0022	0.022	0.0186
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0097	0.1534	1
Giardia lamblia	Aurora kinase	0.0064	0.0949	0.5598
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0324	0.5538	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0022	0.022	0.0149
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0022	0.022	0.5
Echinococcus multilocularis	ATP binding cassette sub family B	0.0022	0.0206	0.0914
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0022	0.022	0.1009
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0.022	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0.0949	0.6189
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0022	0.022	0.5
Loa Loa (eye worm)	AUR protein kinase	0.0064	0.0949	0.0883
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.0949	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0064	0.0949	0.6189
Brugia malayi	P-glycoprotein-like protein	0.0022	0.022	0.027
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0206	0.0914
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0097	0.1534	1
Trypanosoma cruzi	hypothetical protein	0.0074	0.1137	0.6976
Entamoeba histolytica	P-glyco protein 6, putative	0.0022	0.022	0.1434
Onchocerca volvulus		0.0022	0.022	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.022	0.0186
Brugia malayi	ABC transporter	0.0022	0.0206	0.0245
Echinococcus granulosus	multidrug resistance protein 1	0.0022	0.022	0.1009
Trypanosoma cruzi	cdc2-related kinase 1	0.0049	0.0687	0.3551
Brugia malayi	ABC transporter	0.0022	0.022	0.027
Brugia malayi	ABC transporter family protein	0.0022	0.022	0.027
Brugia malayi	ABC transporter family protein	0.0022	0.022	0.027
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0022	0.0206	0.0914
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0022	0.022	0.5
Loa Loa (eye worm)	multidrug resistance protein 3	0.0022	0.022	0.0149
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0022	0.022	0.5
Trypanosoma cruzi	cdc2-related kinase 3	0.0049	0.0687	0.3551
Echinococcus granulosus	multidrug resistance associated protein 1	0.0097	0.1534	1
Echinococcus granulosus	multidrug resistance associated protein 4	0.0074	0.1137	0.7282
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0064	0.0949	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Giardia lamblia	MRP-like ABC transporter	0.0097	0.1534	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0097	0.1534	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0022	0.022	0.1009
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0022	0.022	0.0186
Schistosoma mansoni	multidrug resistance protein	0.0097	0.1534	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0022	0.022	0.1434
Plasmodium falciparum	protein kinase 5	0.0049	0.0687	0.6397
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0097	0.1534	1
Loa Loa (eye worm)	STAT protein	0.0324	0.5538	0.5505
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0097	0.1534	1
Echinococcus granulosus	cyclin dependent kinase	0.0049	0.0687	0.4202
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0064	0.0949	0.6189
Echinococcus granulosus	ATP binding cassette sub family B	0.0022	0.022	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1534	0.1472
Schistosoma mansoni	smdr2	0.0022	0.022	0.1009
Entamoeba histolytica	cell division protein kinase 2, putative	0.0049	0.0687	0.4476
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0022	0.022	0.1009
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0064	0.0949	0.6
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0097	0.1534	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0576	1	1
Entamoeba histolytica	hypothetical protein	0.0097	0.1534	1
Leishmania major	p-glycoprotein e	0.0097	0.1534	1
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0687	0.6464
Loa Loa (eye worm)	hypothetical protein	0.0576	1	1
Schistosoma mansoni	multidrug resistance protein	0.0022	0.022	0.1009
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0064	0.0949	0.6189
Trichomonas vaginalis	ABC transporter, putative	0.0022	0.022	0.0186
Brugia malayi	multidrug resistance related protein 1	0.0097	0.1534	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0576	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0022	0.022	0.0186
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0022	0.022	0.5
Trichomonas vaginalis	abcb9, putative	0.0022	0.022	0.0186
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0687	0.6464
Giardia lamblia	Multidrug resistance-associated protein 1	0.0097	0.1534	1
Loa Loa (eye worm)	ABC transporter	0.0022	0.022	0.0149
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.022	0.0186
Brugia malayi	ABC transporter family protein	0.0022	0.022	0.027
Entamoeba histolytica	P-glycoprotein 6, putative	0.0022	0.022	0.1434
Entamoeba histolytica	multidrug resistance protein, putative	0.0097	0.1534	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (functional)	= 81 %	Inhibition of PrPC polymerization by PrP-res at 100 uM	ChEMBL.	15481988
Control (functional)	= 81 %	Inhibition of PrPC polymerization by PrP-res at 100 uM	ChEMBL.	15481988
ED50 (functional)	= 500 nM	Effective dose required for the inhibition of PrP-res formation in SMB cells	ChEMBL.	15481988
Inhibition (functional)	+ve 0	Inhibition of PrP-res formation in SMB (Scrapie mouse brain) cells at 10 uM	ChEMBL.	15481988

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL188927
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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 330697