Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.1183 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0488 | 0.412 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0315 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0057 | 0.1183 | 0.0858 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0628 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0628 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0488 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0488 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0057 | 0.1183 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0488 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0315 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0628 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.1183 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0628 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.1183 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.1052 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.1183 | 0.0731 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0356 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0041 | 0.0628 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.1183 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.1183 | 0.0731 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0315 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0315 | 1 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0315 | 1 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0488 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0315 | 1 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0488 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0488 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0488 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0488 | 0.4635 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0315 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentaration against Candida tropicalis ATCC750 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida albicans A261 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida albicans V-01-191 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida parapsilosis ATCC22019 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida glabrata ATCC90030 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida albicans A261 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentaration against Candida albicans V-01-191 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentaration against Candida krusei ATCC6528 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentaration against Candida krusei 1766-1 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentaration against Aspergillus fumigatus LSI-11 evaluated by invtro agar diffusion and microbroth dilution assay | ChEMBL. | 15978808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.