Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0082 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0012 | 0.0075 | 0.0075 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0032 | 0.2877 | 1 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0082 | 1 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0032 | 0.2877 | 0.2877 |
Brugia malayi | intracellular kinase | 0.0032 | 0.2877 | 0.2824 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0032 | 0.2877 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0082 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0032 | 0.2877 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0032 | 0.2877 | 0.2823 |
Trypanosoma brucei | protein kinase, putative | 0.0032 | 0.2877 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0032 | 0.2877 | 0.2877 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.2877 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0032 | 0.2877 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0032 | 0.2877 | 0.2824 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0082 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0032 | 0.2877 | 1 |
Onchocerca volvulus | 0.0075 | 0.8956 | 1 | |
Loa Loa (eye worm) | Carm1-pending protein | 0.0082 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0032 | 0.2877 | 0.2877 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0032 | 0.2877 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0032 | 0.2877 | 0.2824 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0032 | 0.2877 | 0.2824 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0032 | 0.2877 | 0.2877 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0032 | 0.2877 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Giardia lamblia | Kinase, CMGC GSK | 0.0032 | 0.2877 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0032 | 0.2877 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0032 | 0.2877 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0012 | 0.0075 | 0.0075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.5 mM | Inhibition of HL-60 cell adhesion to recombinant human Selectin P | ChEMBL. | 15936191 |
IC50 (binding) | = 19.5 mM | Inhibition of HL-60 cell adhesion to recombinant human Selectin P | ChEMBL. | 15936191 |
IC50 (binding) | > 50 mM | Inhibition of HL-60 cell adhesion to recombinant human Selectin E | ChEMBL. | 15936191 |
IC50 (binding) | > 50 mM | Inhibition of HL-60 cell adhesion to recombinant human Selectin E | ChEMBL. | 15936191 |
Inhibition (binding) | = 46 % | Inhibition of HL-60 cell adhesion to recombinant human Selectin E at 50 mM | ChEMBL. | 15936191 |
Inhibition (binding) | = 46 % | Inhibition of HL-60 cell adhesion to recombinant human Selectin E at 50 mM | ChEMBL. | 15936191 |
Inhibition (binding) | = 88 % | Inhibition of HL-60 cell adhesion to recombinant human Selectin P at 50 mM | ChEMBL. | 15936191 |
Inhibition (binding) | = 88 % | Inhibition of HL-60 cell adhesion to recombinant human Selectin P at 50 mM | ChEMBL. | 15936191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.