Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | enteropeptidase | 0.0891 | 0.0831 | 0.0685 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.389 | 0.9447 | 0.9419 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0891 | 0.0831 | 0.0371 |
Echinococcus granulosus | Mastin | 0.0891 | 0.0831 | 0.0685 |
Toxoplasma gondii | kringle domain-containing protein | 0.2562 | 0.5632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2562 | 0.5632 | 0.5961 |
Onchocerca volvulus | 0.389 | 0.9447 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.2562 | 0.5632 | 0.5 |
Onchocerca volvulus | 0.0701 | 0.0287 | 0.0304 | |
Loa Loa (eye worm) | hypothetical protein | 0.389 | 0.9447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0768 | 0.0478 | 0.0506 |
Onchocerca volvulus | 0.0768 | 0.0478 | 0.0506 | |
Onchocerca volvulus | 0.2562 | 0.5632 | 0.5961 | |
Brugia malayi | Muscle positioning protein 4 | 0.0701 | 0.0287 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.2562 | 0.5632 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0478 | 0.0506 |
Loa Loa (eye worm) | trypsin family protein | 0.0768 | 0.0478 | 0.0506 |
Onchocerca volvulus | 0.0768 | 0.0478 | 0.0506 | |
Echinococcus multilocularis | Mastin | 0.0891 | 0.0831 | 0.0685 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Brugia malayi | Protein kinase domain containing protein | 0.2562 | 0.5632 | 0.5961 |
Toxoplasma gondii | PAN domain-containing protein | 0.1492 | 0.2559 | 0.4543 |
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 0.0287 | 0.0304 |
Toxoplasma gondii | PAN domain-containing protein | 0.1492 | 0.2559 | 0.4543 |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0478 | 0.0506 |
Schistosoma mansoni | hypothetical protein | 0.2562 | 0.5632 | 0.5412 |
Brugia malayi | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Echinococcus granulosus | enteropeptidase | 0.0891 | 0.0831 | 0.0685 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.2562 | 0.5632 | 1 |
Brugia malayi | Trypsin family protein | 0.389 | 0.9447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.389 | 0.9447 | 1 |
Onchocerca volvulus | 0.3122 | 0.7241 | 0.7665 | |
Onchocerca volvulus | 0.0768 | 0.0478 | 0.0506 | |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0478 | 0.0506 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0891 | 0.0831 | 0.0685 |
Brugia malayi | Kringle domain containing protein | 0.2562 | 0.5632 | 0.5961 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2562 | 0.5632 | 0.5 |
Onchocerca volvulus | 0.0768 | 0.0478 | 0.0506 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.2562 | 0.5632 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0865 | 0.0758 | 0.0294 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.2562 | 0.5632 | 0.5961 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0478 | 0.0506 |
Echinococcus granulosus | tissue type plasminogen activator | 0.2562 | 0.5632 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0891 | 0.0831 | 0.0685 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0768 | 0.0478 | 0.0506 |
Onchocerca volvulus | 0.0768 | 0.0478 | 0.0506 | |
Mycobacterium ulcerans | hypothetical protein | 0.0768 | 0.0478 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.57 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
IC50 (binding) | = 0.57 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.